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CDS information : Gelda2_00190


close this sectionLocation

Organism
StrainNRRL 3602 (=NBRC 14620)
Entry nameGeldanamycin
Contig
Start / Stop / Direction73,583 / 70,803 / - [in whole cluster]
62,283 / 59,503 / - [in contig]
Locationcomplement(70803..73583) [in whole cluster]
complement(59503..62283) [in contig]
TypeCDS
Length2,781 bp (926 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative LuxR family transcriptional activator
Product (GenBank)GdmRII
Gene
Gene (GenBank)gdmRII
EC number
Keyword
Note
Note (GenBank)
  • putative transcriptional regulator; LuxR family
Reference
ACC
PmId
[12586396] Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602. (FEMS Microbiol Lett. , 2003)
Related Reference
ACC
Q06BL5
NITE
Gelda_00100
PmId
[18214443] The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. (Arch Microbiol. , 2008)
ACC
Q9ZGI0
NITE
Pikro_00180
PmId
[11344155] Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. (J Bacteriol. , 2001)
[18245260] Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae. (Appl Environ Microbiol. , 2008)
[26608164] Interspecies Complementation of the LuxR Family Pathway-Specific Regulator Involved in Macrolide Biosynthesis. (J Microbiol Biotechnol. , 2016)

close this sectionSequence

selected fasta
>putative LuxR family transcriptional activator [GdmRII]
MPYSYAMPLNTESNSRPMGGVLHTAAYLGHPFGDSLVRPGQALLVDGPLACGKTTLLRSF
AERASEAGYLTVTATCSPSERDLPFGVVSQLARGAWKSPGGLPEVPGLPDILRAAGDPLD
QAGIARLCHRLCTSLIDHAEHTPLLVAVDDVRHSDAASAHFLLQLVRRLDSARIAAVFTD
DLSLPSSLPLRYELLRAQHLRRIGLGPLSPGQVAEVVVAELGETARRHVGDICAATGGNR
LLLHTLLSDYREHGEASQAGYGQSFLSCLHRNEPIFLDVVRALAVVGSALPAADLAWMTG
HEPEPISQVLAALTGAGLMDEGEFRQEAARLSVLNDMPAQARRTLHQRAARLLHDQGRPA
TAIARHLVRAGQIPDSWSAEVLLEVAEQVAVGEEASIAVDLLEQSFEQCPHEERRAALQA
KLAGAEWKINPSTATRHHAPLYAAVRAGRLGLPDSVTLLMQLLWKGGLSEVEGLLAHLRE
DPAATDQLHAIEAALTCTYPWLAERRAAPAHHGGSAATRAAVWPRAGTVLADVLTGGQTH
DTVRRAEEVLRELQLGHDPACHEQAGLFALLALVYGGRNDLASAWCEGALGETGGGPHVP
MRQAVLSAARSEIALRRGDLAEAAEQSRAALTHASPGAWGVAIGLPLGALILACTRMGRH
EEAGFHVAQTVPNAMFKSSYGLHYLYARGHYFLAAGRHQAALADFLLCGELLTDWGLSSG
CDPVPWRIGAAEAWLAQGNHDQARILVYQQLSRPHTDGARARGQSLRLLAATSSAKRRPQ
LLNEAVGLFTEQEDKYELARTLWDLSQAYHALGEKKQARRTMRRAWHVAKMCDAASLYEE
WLPADDQHHATAPTPKSDTAIERLTHSERRVASLAAMGYTNREIAGKLYVTASTVEQHLT
RVFRKLDIKHREQLPTELYVDRPELA
selected fasta
>putative LuxR family transcriptional activator [GdmRII]
ATGCCCTACAGCTATGCCATGCCGTTGAATACCGAGTCGAATTCCCGTCCGATGGGCGGG
GTATTGCATACCGCGGCGTACCTCGGACATCCATTCGGTGACTCTTTGGTGCGGCCCGGG
CAGGCTCTTCTCGTGGACGGACCGCTGGCATGCGGGAAGACGACCCTGCTCCGGTCGTTC
GCCGAGCGAGCCTCCGAGGCCGGCTATCTCACCGTCACAGCGACGTGTTCCCCCAGCGAG
CGGGACCTTCCCTTCGGGGTCGTCTCACAATTGGCCCGCGGCGCCTGGAAATCACCGGGC
GGGCTGCCCGAGGTACCGGGGCTGCCGGACATCCTCCGCGCGGCCGGCGATCCGCTGGAC
CAGGCCGGGATCGCCCGGCTGTGCCACCGGCTGTGCACCTCGCTGATCGACCACGCGGAA
CACACGCCGCTGCTCGTCGCCGTGGACGATGTCCGGCACAGCGACGCGGCCTCCGCACAC
TTCCTCCTGCAACTGGTGCGGCGCCTGGACTCGGCGCGCATCGCGGCCGTATTCACCGAC
GACTTGAGCCTGCCGTCGTCCCTGCCGCTCCGCTACGAACTGCTGCGCGCCCAGCACCTG
CGCCGCATCGGCCTGGGCCCGCTCTCCCCCGGCCAGGTGGCCGAAGTGGTCGTGGCGGAG
CTGGGGGAGACCGCGCGCCGCCACGTCGGCGACATCTGCGCCGCCACCGGTGGCAACCGG
CTGCTGCTGCACACTCTGCTGTCCGACTATCGCGAACACGGCGAGGCCAGCCAGGCCGGC
TACGGCCAGTCCTTCCTGAGCTGCCTGCACCGCAATGAGCCGATCTTCCTGGACGTGGTG
CGCGCACTGGCCGTGGTGGGATCCGCCCTGCCCGCCGCCGACCTCGCCTGGATGACCGGA
CACGAGCCCGAGCCCATCAGCCAGGTGCTCGCGGCGCTGACCGGGGCCGGACTGATGGAC
GAGGGCGAGTTCCGGCAGGAGGCGGCGCGGTTGAGCGTGCTCAACGACATGCCGGCACAG
GCCCGCAGGACCCTGCACCAGCGGGCCGCGCGGCTGCTGCACGACCAGGGCAGGCCCGCC
ACCGCGATCGCCCGTCATCTGGTGCGGGCCGGGCAGATCCCCGACTCGTGGTCGGCCGAG
GTGCTTCTGGAAGTGGCCGAGCAGGTGGCGGTGGGCGAAGAGGCGTCCATCGCCGTCGAC
TTACTGGAGCAGTCCTTCGAGCAATGCCCGCACGAAGAGCGCCGTGCAGCCCTGCAGGCG
AAGCTCGCCGGGGCGGAATGGAAGATCAATCCGTCCACCGCCACGCGGCACCACGCACCG
CTGTACGCCGCCGTCCGCGCCGGCCGGCTCGGCCTCCCCGACAGCGTCACCCTGCTCATG
CAGCTCCTGTGGAAGGGGGGACTGAGCGAGGTGGAGGGGCTGCTCGCCCACCTGCGCGAG
GACCCCGCGGCCACGGACCAGCTCCATGCCATCGAGGCGGCACTCACCTGCACCTATCCC
TGGCTGGCGGAGCGGCGGGCGGCCCCGGCACACCACGGTGGCTCCGCGGCGACACGGGCG
GCGGTGTGGCCCCGGGCCGGCACCGTCCTGGCCGACGTGCTCACCGGCGGGCAGACCCAT
GACACCGTCCGGCGGGCCGAGGAGGTGCTGCGCGAACTGCAGCTCGGGCACGACCCGGCA
TGCCACGAGCAGGCGGGGCTGTTCGCCCTGCTCGCCCTGGTCTACGGCGGCCGGAACGAC
CTGGCGTCCGCCTGGTGCGAGGGTGCGCTCGGCGAGACCGGTGGGGGACCGCACGTCCCG
ATGCGGCAGGCGGTGCTGTCGGCGGCCAGGTCCGAGATCGCACTGCGCCGCGGTGACCTC
GCCGAGGCCGCGGAGCAGTCCCGCGCCGCCCTCACCCACGCCTCCCCCGGCGCCTGGGGT
GTCGCGATCGGGCTGCCGCTCGGCGCCCTCATCCTGGCGTGTACGCGGATGGGGCGGCAC
GAGGAGGCGGGGTTCCATGTCGCGCAGACCGTGCCCAACGCCATGTTCAAAAGCTCCTAC
GGGCTGCACTACCTGTACGCGCGCGGCCACTACTTCCTGGCGGCCGGCCGGCACCAGGCC
GCGCTCGCGGACTTCCTGCTGTGCGGTGAACTGCTCACCGACTGGGGGCTGAGCAGCGGC
TGCGACCCGGTGCCGTGGCGGATCGGGGCGGCGGAGGCATGGCTGGCGCAGGGCAACCAC
GACCAGGCCCGGATCCTGGTGTACCAGCAGCTCAGCCGTCCGCACACGGACGGCGCCCGG
GCCCGCGGGCAGTCGTTGCGTCTTCTGGCGGCCACCAGTTCGGCGAAGCGGCGGCCGCAG
TTGCTCAACGAGGCGGTGGGCCTGTTCACCGAGCAGGAGGACAAGTACGAGCTGGCCCGC
ACGCTGTGGGACCTCAGCCAGGCGTACCACGCGCTCGGTGAGAAGAAGCAGGCCCGCCGG
ACCATGCGCCGGGCCTGGCATGTGGCGAAGATGTGCGACGCGGCGTCGCTGTACGAGGAG
TGGCTGCCGGCCGACGACCAGCACCATGCCACCGCACCAACGCCGAAGTCGGACACCGCG
ATCGAGCGGCTGACGCACTCCGAACGGCGTGTCGCGTCGCTGGCCGCGATGGGCTACACC
AACCGGGAGATCGCCGGGAAGCTGTACGTCACGGCCAGCACGGTGGAGCAGCATCTGACC
CGGGTGTTCCGCAAGCTGGACATCAAGCACCGGGAGCAACTGCCCACCGAACTGTACGTC
GACCGGCCGGAGTTGGCGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [864-878]  7.30000590915208e-09 PR00038 [878-894]  7.30000590915208e-09 PR00038 [894-906]  7.30000590915208e-09 PR00038
PR00038   HTHLUXR
 [878-905]  PS00622
PS00622   HTH_LUXR_1
 [857-922]  PS50043
PS50043   HTH_LUXR_2
 [862-914]  3.7e-11 PF00196
PF00196   GerE
 [861-918]  4.00000300869883e-20 SM00421
SM00421   HTH_LUXR
IPR011990 Tetratricopeptide-like helical (Domain)
 [685-871]  1.4e-13 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [872-914]  1.69999999999999e-17 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [842-914]  1.69999922284049e-15 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP No significant hit
TMHMM No significant hit