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CDS information : Gelda_00200


close this sectionLocation

Organism
Strain17997
Entry nameGeldanamycin
Contig
Start / Stop / Direction2,479 / 2,033 / - [in whole cluster]
6,423 / 6,869 / + [in contig]
Locationcomplement(2033..2479) [in whole cluster]
6423..6869 [in contig]
TypeCDS
Length447 bp (148 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category2.2 modification addition of starter unit
Productputative aminodehydroquinate dehydratase
Product (GenBank)aminoDHQ dehydratase
Gene
Gene (GenBank)gdnE
EC number
Keyword
  • AHBA
Note
Note (GenBank)
Reference
ACC
PmId
[16502293] Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. (Curr Microbiol. , 2006)
Related Reference
ACC
Q7BUF8
NITE
Rifam_00600
PmId
[11278540] Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. (J Biol Chem. , 2001)
ACC
P43877
PmId
[8170389] Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. (Mol Microbiol. , 1994)
ACC
Q49BC2
NITE
Gelda2_00270
PmId
[16085885] Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. (Appl Environ Microbiol. , 2005)

close this sectionSequence

selected fasta
>putative aminodehydroquinate dehydratase [aminoDHQ dehydratase]
MRCPLSRLLLVNGPNLGILGKRQPEIYGTDTLQDIERWVGEEVAERGWKVDSYQFDGEAE
IIQTIQGNYDTVGAIINPAALMMAGWGLRDALANYPRPWIEVHLSNVWAREQFRHESVTG
PLAAGVIFGLGALGYRLAARALLDKVPD
selected fasta
>putative aminodehydroquinate dehydratase [aminoDHQ dehydratase]
GTGAGGTGCCCATTGAGCAGGCTGTTGTTGGTGAACGGACCGAATCTCGGCATACTCGGC
AAGCGCCAGCCCGAGATCTACGGCACGGATACGCTTCAGGACATCGAGCGCTGGGTCGGG
GAAGAGGTCGCGGAGCGCGGCTGGAAAGTGGATTCCTACCAGTTCGATGGCGAAGCGGAG
ATCATCCAGACCATTCAGGGGAACTACGACACGGTCGGTGCCATCATCAATCCGGCCGCG
CTCATGATGGCCGGATGGGGCCTTCGGGACGCACTGGCGAACTATCCGCGGCCCTGGATA
GAAGTGCATCTGTCGAATGTCTGGGCCCGTGAGCAGTTCCGCCATGAGTCGGTGACCGGA
CCGCTGGCCGCGGGTGTCATCTTCGGGCTCGGCGCCCTGGGCTACCGGCTCGCCGCCCGC
GCCCTGCTCGACAAGGTGCCGGACTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001874 Dehydroquinase, class II (Family)
 [6-146]  5.89999999999994e-51 G3DSA:3.40.50.9100
G3DSA:3.40.50.9100   DHquinase_II
 [4-148]  6.29998179434741e-78 PIRSF001399
PIRSF001399   DHquinase_II
 [7-143]  5.40000000000002e-47 PF01220
PF01220   DHquinase_II
 [6-148]  2.60000517657733e-45 SSF52304
SSF52304   DHquinase_II
 [9-128]  PD004527
PD004527   DHquinase_II
IPR018509 Dehydroquinase, class II, conserved site (Conserved_site)
 [11-28]  PS01029
PS01029   DEHYDROQUINASE_II
SignalP No significant hit
TMHMM No significant hit