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CDS information : Griseo_00270


close this sectionLocation

Organism
StrainJP95
Entry nameGriseorhodin A
Contig
Start / Stop / Direction29,796 / 30,230 / + [in whole cluster]
29,796 / 30,230 / + [in contig]
Location29796..30230 [in whole cluster]
29796..30230 [in contig]
TypeCDS
Length435 bp (144 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.3 modification reduction
Productputative oxidoreductase
Product (GenBank)GrhS
Gene
Gene (GenBank)grhS
EC number
Keyword
Note
Note (GenBank)
  • similar to TcmJ
Reference
ACC
PmId
[12323376] A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A. (Chem Biol. , 2002)
Related Reference
ACC
P23157
PmId
[15701630] A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides. (J Biol Chem. , 2005)
ACC
P16558
PmId
[8244926] The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase. (J Bacteriol. , 1993)
[8248801] Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. (Science. , 1993)
[9609708] Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis. (Biochemistry. , 1998)

close this sectionSequence

selected fasta
>putative oxidoreductase [GrhS]
MTTAAATPAKVNLAEVAPNRKRGGDIRITLSPRTTGCTSGFGGTLRLEAGEYVTEHLHPY
SEEFLHVVTGTLEITLDGAPVALGPGDSLLVPINMRHRLVNTGPEPAQVVFHLSPLAPRP
ELGHVDTEAPLDGNGANPDVGGAS
selected fasta
>putative oxidoreductase [GrhS]
ATGACGACCGCGGCGGCCACCCCGGCCAAGGTCAACCTGGCGGAGGTCGCCCCCAACCGC
AAGCGCGGCGGCGACATCCGCATCACCCTCAGCCCGCGCACGACCGGCTGCACCTCCGGG
TTCGGCGGCACGCTGCGGCTGGAGGCGGGCGAGTACGTCACCGAGCACCTCCACCCGTAC
TCGGAGGAGTTCCTGCACGTCGTCACCGGCACGCTGGAGATCACCCTGGACGGCGCGCCC
GTCGCCCTGGGCCCCGGCGACTCGCTGCTGGTCCCGATCAACATGCGCCACCGCCTGGTG
AACACCGGGCCGGAGCCGGCGCAGGTCGTCTTCCACCTGTCGCCGCTCGCGCCCCGCCCG
GAGCTGGGCCACGTCGACACCGAGGCCCCGCTCGACGGGAACGGCGCCAACCCCGACGTG
GGGGGAGCGTCGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR011051 RmlC-like cupin domain (Domain)
 [1-132]  4.80000830876748e-25 SSF51182
SSF51182   RmlC_like_cupin
IPR013096 Cupin 2, conserved barrel (Domain)
 [45-110]  3.39999999999999e-19 PF07883
PF07883   Cupin_2
IPR014710 RmlC-like jelly roll fold (Domain)
 [22-126]  6.40000000000001e-24 G3DSA:2.60.120.10
G3DSA:2.60.120.10   RmlC-like_jellyroll
IPR016672 Polyketide biosynthesis protein CurC, predicted (Family)
 [1-142]  1.79999754022378e-67 PIRSF016602
PIRSF016602   CurC_prd
SignalP No significant hit
TMHMM No significant hit