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CDS information : Herb_00270


close this sectionLocation

Organism
StrainAM 3672
Entry nameHerbimycin A
Contig
Start / Stop / Direction81,257 / 80,193 / - [in whole cluster]
81,257 / 80,193 / - [in contig]
Locationcomplement(80193..81257) [in whole cluster]
complement(80193..81257) [in contig]
TypeCDS
Length1,065 bp (354 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category2.2 modification addition of starter unit
Productputative aminodehydroquinate synthase
Product (GenBank)HbmO
Gene
Gene (GenBank)hbmO
EC number4.2.3.-
Keyword
  • AHBA
Note
Note (GenBank)
  • putative aminoDHQ synthase
Reference
ACC
PmId
[16085885] Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. (Appl Environ Microbiol. , 2005)
Related Reference
ACC
O52549
NITE
Rifam_00280
PmId
[11278540] Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. (J Biol Chem. , 2001)
ACC
P0A4Z4
PmId
[17586643] Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification. (J Bacteriol. , 2007)
[1910148] The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. (Mol Gen Genet. , 1991)

close this sectionSequence

selected fasta
>putative aminodehydroquinate synthase [HbmO]
MTTSTSTSATGSASPARQVTVGLAERSYTVHIGHGVQRLLPQVVAALGARRAVVVTARPA
GQTPDPGVPSLVVPARDGEEAKDLAAVTDLCRRFVGFGLTRSDVVVSCGGGTTTDTVGLA
AALYHRGTPVVHVPTSLLAQVDASVGGKTAVNLPEGKNLVGAYWQPAAVLCDLEHLKTLP
DREWRNGLGEIARCHFIGAPDLDGLPLLDQISASVTLKAGIVAADERDSGLRHLLNYGHT
LGHALERATGFALRHGEGVAIGTVFAGRLAGALGRIGPERVAEHHDVVSRYGLPTGLPPD
VSVSELVELMRLDKKATDGLTFVLDGPEGPGLVRGIPEDTVSTTLAAMPRAPAW
selected fasta
>putative aminodehydroquinate synthase [HbmO]
TTGACCACGTCGACTTCCACTTCGGCCACCGGCTCCGCGTCCCCTGCCCGGCAGGTCACC
GTCGGGCTGGCCGAACGCTCCTACACCGTTCACATCGGCCACGGTGTGCAGCGGCTGCTG
CCACAGGTGGTGGCCGCCCTGGGCGCGCGCAGGGCGGTGGTGGTCACCGCGCGGCCCGCC
GGGCAGACCCCCGACCCGGGAGTGCCCTCGCTCGTCGTGCCCGCCCGCGACGGGGAGGAG
GCCAAGGACCTGGCCGCCGTGACGGACCTGTGCCGCCGGTTCGTCGGATTCGGACTCACC
CGCTCGGATGTGGTGGTGTCCTGTGGCGGCGGCACCACGACCGACACGGTGGGCCTGGCC
GCCGCCCTCTACCACCGGGGCACCCCGGTCGTTCATGTGCCGACCTCGCTGCTCGCCCAG
GTGGACGCGAGCGTCGGCGGGAAGACCGCGGTGAATCTGCCCGAGGGCAAGAACCTGGTC
GGCGCCTACTGGCAGCCCGCGGCCGTGCTCTGCGACCTCGAGCATCTGAAAACCCTGCCC
GACCGGGAATGGCGCAACGGCCTCGGTGAGATCGCCCGCTGCCACTTCATCGGCGCGCCC
GACCTCGACGGGCTGCCGCTGCTCGACCAGATCTCGGCCAGTGTGACGCTCAAGGCGGGC
ATCGTCGCGGCGGACGAACGCGACTCCGGCCTGCGCCACCTCCTCAACTACGGACACACC
TTGGGGCATGCGCTGGAACGCGCCACCGGGTTCGCACTGCGCCACGGCGAGGGCGTGGCC
ATCGGCACGGTCTTCGCCGGCCGGCTCGCCGGCGCGCTGGGGCGCATCGGCCCGGAACGG
GTCGCCGAGCACCATGACGTCGTATCCCGCTACGGCCTGCCGACCGGGCTGCCGCCGGAT
GTCTCGGTGTCCGAGCTGGTGGAGCTGATGCGCCTGGACAAGAAGGCCACCGACGGGCTG
ACGTTCGTCCTGGACGGCCCCGAGGGGCCCGGACTGGTGCGCGGGATCCCCGAGGACACC
GTCAGCACCACCCTCGCGGCGATGCCCCGCGCGCCCGCATGGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR016037 3-dehydroquinate synthase AroB (Family)
 [17-353]  2.89997807423186e-78 PIRSF001455
PIRSF001455   DHQ_synth
SignalP
 [1-18]  0.5 Signal
Bacteria, Gram-negative   
 [1-24]  0.371 Signal
Bacteria, Gram-positive   
TMHMM No significant hit