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CDS information : Kirro_00380


close this sectionLocation

Organism
StrainTü365
Entry nameKirromycin
Contig
Start / Stop / Direction97,618 / 96,872 / - [in whole cluster]
97,618 / 96,872 / - [in contig]
Locationcomplement(96872..97618) [in whole cluster]
complement(96872..97618) [in contig]
TypeCDS
Length747 bp (248 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.3 transport
Productputative drug resistance transporter(fragment)
Product (GenBank)putative major facilitator family transporter
Gene
Gene (GenBank)kirTII
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[18291322] Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety. (Chem Biol. , 2008)
Related Reference
ACC
P46105
NITE
Actino_00140
PmId
[1878971] The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. (Cell. , 1991)
[8636024] Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2). (J Bacteriol. , 1996)
[17644591] Investigation of transcription repression and small-molecule responsiveness by TetR-like transcription factors using a heterologous Escherichia coli-based assay. (J Bacteriol. , 2007)
[17338074] Initiation of actinorhodin export in Streptomyces coelicolor. (Mol Microbiol. , 2007)

close this sectionSequence

selected fasta
>putative drug resistance transporter(fragment) [putative major facilitator family transporter]
MSEEAKSTTAEAALGPPVAADGPDPKRWLALIVLLAATFMDLLDVNIVTVAIPSVQKDLG
ASSAAVQALNVGYTLSFAVTLITGGRLGDIFGRKRAFLIGVAGFVVASALCAFAPSAEVL
VTSRVLQGMAAAIMVPQVLAVIYVTFPAEEIGRVVSLYASMIGLAIVAGPLLGGVLISWD
PGGLGWRTVFLVNLPFGVAALIAGALWMRESKSPRATRLDLVGMVLVTTGLLLLLLPLLR
GRELGWPA
selected fasta
>putative drug resistance transporter(fragment) [putative major facilitator family transporter]
ATGAGCGAGGAAGCGAAGTCGACGACGGCGGAAGCGGCTCTCGGACCGCCCGTCGCCGCC
GACGGCCCGGACCCCAAGCGCTGGTTGGCGCTGATCGTCCTGCTTGCCGCGACCTTCATG
GACCTGCTCGACGTCAACATCGTCACCGTGGCGATCCCGAGCGTTCAGAAGGACCTCGGC
GCCTCCTCGGCCGCCGTCCAGGCGCTGAACGTCGGTTACACCCTGTCCTTCGCGGTCACA
CTGATCACCGGCGGCCGGCTCGGCGACATCTTCGGCCGCAAACGGGCCTTCCTGATCGGC
GTCGCCGGCTTCGTCGTGGCGTCGGCCCTGTGTGCCTTCGCCCCCAGCGCCGAAGTCCTG
GTGACGTCCCGGGTGCTGCAGGGCATGGCCGCCGCCATCATGGTGCCGCAGGTCCTGGCG
GTCATCTACGTGACCTTTCCGGCGGAGGAGATCGGCCGGGTCGTGAGTCTGTACGCCAGC
ATGATCGGCCTGGCCATCGTCGCCGGACCGCTGCTGGGCGGCGTGCTGATCTCCTGGGAC
CCGGGCGGCCTGGGCTGGCGGACCGTCTTCTTGGTCAACCTGCCGTTCGGCGTGGCCGCC
CTGATCGCCGGCGCGCTGTGGATGCGCGAGTCGAAGTCGCCCCGCGCCACCCGGCTGGAC
CTGGTCGGCATGGTGCTGGTGACCACCGGCCTGCTGTTGCTGCTGCTGCCCCTGCTGCGC
GGCCGCGAACTCGGCTGGCCCGCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG (Family)
 [40-56]  2.90000036269908e-05 PR01035 [97-121]  2.90000036269908e-05 PR01035 [155-177]  2.90000036269908e-05 PR01035
PR01035   TCRTETA
IPR011701 Major facilitator superfamily (Family)
 [34-217]  5.10000000000004e-35 PF07690
PF07690   MFS_1
IPR016196 Major facilitator superfamily domain, general substrate transporter (Domain)
 [1-214]  3.49999466863949e-51 SSF103473
SSF103473   MFS_gen_substrate_transporter
IPR020846 Major facilitator superfamily domain (Domain)
 [30-248]  PS50850
PS50850   MFS
SignalP
 [1-40]  0.22 Signal
Eukaryota   
TMHMM
 [31-53]  Transmembrane (i-o) [63-85]  Transmembrane (o-i) [98-120]  Transmembrane (i-o) [125-147]  Transmembrane (o-i) [154-176]  Transmembrane (i-o) [186-208]  Transmembrane (o-i) [221-239]  Transmembrane (i-o)
Transmembrane 7