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CDS information : Madu_00070


close this sectionLocation

Organism
StrainATCC 39144
Entry nameMaduropeptin
Contig
Start / Stop / Direction14,848 / 13,466 / - [in whole cluster]
14,848 / 13,466 / - [in contig]
Locationcomplement(13466..14848) [in whole cluster]
complement(13466..14848) [in contig]
TypeCDS
Length1,383 bp (460 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.3 modification reduction
Productputative monooxygenase
Product (GenBank)epoxidase
Gene
Gene (GenBank)mdpL
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[17918933] Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. (J Am Chem Soc. , 2007)
Related Reference
ACC
B5M9L6
NITE
Lasal_00200
PmId
[22506807] Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis. (J Am Chem Soc. , 2012)
[23796908] Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton. (Curr Opin Chem Biol. , 2013)
ACC
B5M9L6
NITE
Lasal2_00240
PmId
[19025863] Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. (Chembiochem. , 2008)
ACC
Q846W9
NITE
Monen_00220
PmId
[12940979] Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. (Mol Microbiol. , 2003)

close this sectionSequence

selected fasta
>putative monooxygenase [epoxidase]
MSELGKRAVVLGGSMAGTLAARVLSEFYGEVLVVERDAVLGVRTPRRGAPHTVHAHGLHA
RGHLIVEELFPGLTDELRADGVPTGDIAGMRWYFNARRIMPADTGLVSLTAPRPVLEAHV
RARTAALPGVTYLERHSIIGLLTTADRTRVTGVRVERRDEPGEIELEADVVVDATGRGSR
TPAWLEELGYRRPEEERVKVGLAYTTRHYRTRPEWFDGVQSINPVASPAHPRGAFFGQVG
PDTCILSLTGILGDHPPTDPEAFLEFARTLPVPDVYEAVRDGEALDDPVSFRFPASVRRR
YERLDRFPDRLLVLGDAVCSFNPVYGQGMSVAAIEAMELRRHLRQGAPRPAEYLTAVARA
VDAPWEVSAGGDLDFPGVEGRRTLKVRAGNAYMARLQYAATKDPKVTEGFMRVAGLMDPP
TALMRPGMAARVLRHAIRRPAPGRSWLDGRSPAADPARSS
selected fasta
>putative monooxygenase [epoxidase]
ATGAGTGAACTCGGAAAGCGGGCCGTGGTTCTGGGCGGCAGCATGGCGGGCACGCTCGCC
GCGCGGGTCCTTTCGGAATTCTACGGCGAGGTCCTGGTCGTCGAACGTGACGCGGTGCTC
GGTGTCCGGACGCCGAGGCGGGGGGCACCGCACACCGTCCACGCGCACGGCCTGCACGCG
CGCGGCCACCTGATCGTGGAGGAGCTGTTCCCCGGCCTCACCGACGAGCTGCGCGCGGAC
GGGGTGCCGACCGGGGACATCGCGGGGATGCGCTGGTACTTCAACGCCCGGCGGATCATG
CCGGCCGACACCGGGCTGGTGTCGCTGACGGCCCCGCGCCCCGTCCTGGAGGCGCACGTC
CGGGCGCGGACGGCCGCGCTGCCCGGGGTCACCTACCTGGAGCGGCACTCGATCATCGGC
CTGCTGACCACCGCGGACCGCACCCGGGTCACCGGGGTCCGGGTGGAGCGGCGGGACGAG
CCCGGGGAGATCGAGCTGGAGGCCGACGTGGTCGTGGACGCCACCGGGCGGGGCTCCCGG
ACCCCCGCCTGGCTGGAGGAGCTCGGCTACCGGCGGCCGGAGGAGGAACGCGTCAAGGTC
GGCCTGGCGTACACGACGCGGCACTACCGGACGCGGCCGGAGTGGTTCGACGGCGTCCAG
TCGATCAACCCGGTGGCGTCCCCGGCCCATCCGCGGGGCGCGTTCTTCGGCCAGGTCGGG
CCGGACACCTGCATCCTGTCGCTCACCGGGATCCTCGGCGACCATCCGCCGACCGATCCG
GAGGCGTTCCTGGAGTTCGCGCGGACCCTCCCCGTCCCGGACGTCTACGAGGCGGTCCGC
GACGGCGAGGCCCTCGACGACCCGGTCAGCTTCCGCTTCCCGGCGAGCGTCCGGCGCCGG
TACGAGCGGCTCGACCGGTTCCCCGACCGGCTGCTCGTGCTGGGCGACGCCGTGTGCAGC
TTCAACCCCGTCTACGGGCAGGGCATGAGCGTCGCGGCGATCGAGGCCATGGAGCTGCGC
CGGCACCTGCGGCAGGGGGCGCCCCGCCCCGCCGAGTACCTCACCGCGGTCGCCCGCGCG
GTCGACGCCCCGTGGGAGGTGTCCGCGGGCGGTGACCTCGACTTCCCGGGGGTGGAGGGC
CGCCGCACGCTGAAGGTCCGCGCCGGCAACGCCTACATGGCGCGCCTCCAGTACGCGGCG
ACGAAGGACCCGAAGGTCACCGAGGGGTTCATGCGCGTGGCCGGGCTCATGGACCCTCCC
ACCGCGCTCATGCGCCCCGGCATGGCCGCCCGCGTCCTGCGCCACGCGATCCGCAGGCCG
GCTCCGGGCCGGTCCTGGCTGGACGGCCGGTCCCCGGCGGCCGACCCGGCCCGCTCCTCC
TGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
No significant hit
SignalP No significant hit
TMHMM No significant hit