open/close all

CDS information : Medem_00150

Location

Organism	Streptomyces sp.
Strain	AM-7161
Entry name	Medermycin
Contig	AB103463
Start / Stop / Direction	13,942 / 14,898 / + [in whole cluster] 13,942 / 14,898 / + [in contig]
Location	13942..14898 [in whole cluster] 13942..14898 [in contig]
Type	CDS
Length	957 bp (318 aa)

Annotation

Category	3.4 other modification
Product	putative cyclase/dehydratase
Product (GenBank)	first ring aromatase (ARO)
Gene
Gene (GenBank)	med-ORF19
EC number
Keyword	1st ring
Note
Note (GenBank)
Reference	ACC Q7WT27 PmId [12855716] Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters. (Microbiology. , 2003)
Related Reference	ACC Q54221 NITE Griseu_00050 PmId [8169211] Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus. (J Bacteriol. , 1994) [9195917] Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits. (J Biol Chem. , 1997) [10467128] Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. (Chem Biol. , 1999)
Related Reference	ACC Q56167 NITE Jado_00120 PmId [7881555] Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230. (Microbiology. , 1994) [9224566] Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides. (Chem Biol. , 1997)

Sequence

>putative cyclase/dehydratase [first ring aromatase (ARO)]
MTQPTPRETAHEITVRATAERLYELIADVGGWPSIFPPSVHADHLERGDKEERIRLWATV
DGQVKHWTSRRTLDRAGLRVDFRQEVPSPPMAAMGGAWIIEPTGPGECRVRLLHDFRAVG
DDPGTLDWIDRAVDANSRSELAALKRHAERGADGPGEGDTFLTFEDTVRLEGHVKDVYDF
IDQAQHWADRLPHVTSVNLRDAGPGRQILAMDTLTKDGSPHTTESVRVCVPYERIVYKQT
TLPPLMALHTGEWSFAEDGAGATVVTSRHTAVVEPAAVTRVLGETADLPAARRYLREALG
ANSLATLRHAGEYAAARR

>putative cyclase/dehydratase [first ring aromatase (ARO)]
ATGACCCAGCCCACCCCACGGGAGACCGCCCACGAGATCACCGTCCGCGCGACGGCCGAG
CGGCTCTACGAACTGATCGCCGACGTCGGCGGCTGGCCCTCGATCTTCCCGCCCTCGGTC
CACGCCGACCACCTGGAGCGCGGCGACAAGGAGGAGCGCATCCGGCTCTGGGCCACCGTC
GACGGGCAGGTCAAGCACTGGACGTCCCGGCGCACCCTGGACCGCGCAGGACTCCGCGTC
GACTTCCGGCAGGAGGTGCCGAGTCCGCCGATGGCCGCGATGGGCGGTGCCTGGATCATC
GAACCCACGGGACCGGGGGAGTGCCGCGTACGGCTGCTGCACGACTTCCGGGCCGTCGGC
GACGACCCCGGGACCCTCGACTGGATCGACCGCGCCGTGGACGCCAACAGCCGGTCGGAG
CTCGCCGCCCTCAAGCGCCACGCCGAACGCGGCGCCGACGGCCCGGGCGAGGGCGACACC
TTCCTCACCTTCGAGGACACCGTCCGCCTCGAAGGCCACGTCAAGGACGTCTACGACTTC
ATCGACCAGGCCCAGCACTGGGCCGACCGCCTGCCCCACGTCACGTCCGTGAACCTGCGG
GACGCCGGCCCCGGCCGTCAGATCCTGGCCATGGACACGCTCACCAAGGACGGCAGCCCG
CACACCACCGAGTCGGTGCGCGTCTGCGTCCCGTACGAGCGGATCGTCTACAAGCAGACC
ACCCTGCCCCCGCTGATGGCCCTGCACACCGGCGAGTGGAGCTTCGCGGAGGACGGCGCC
GGCGCCACCGTCGTCACCTCGCGCCACACCGCCGTGGTCGAGCCCGCCGCCGTCACCCGG
GTCCTCGGCGAGACCGCCGACCTGCCGGCGGCGCGTCGCTACCTCCGCGAGGCGCTGGGT
GCGAACAGCCTGGCCACGCTGAGGCACGCCGGAGAGTACGCCGCGGCCCGCCGCTGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR019587 Polyketide cyclase/dehydrase (Region) PF10604 Polyketide_cyc2
SignalP	Bacteria, Gram-negative Eukaryota
TMHMM	No significant hit

Medem_00140 Medem_00160

Advanced search

KS seq Analysis

List

Other

Information