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CDS information : Medem_00160

Location

Organism	Streptomyces sp.
Strain	AM-7161
Entry name	Medermycin
Contig	AB103463
Start / Stop / Direction	14,936 / 16,066 / + [in whole cluster] 14,936 / 16,066 / + [in contig]
Location	14936..16066 [in whole cluster] 14936..16066 [in contig]
Type	CDS
Length	1,131 bp (376 aa)

Annotation

Category	2.3 modification addition of sugar moiety
Product	putative NDP-hexose C-3 aminotransferase
Product (GenBank)	NDP-deoxyhexose 3-aminotransferase
Gene
Gene (GenBank)	med-ORF20
EC number
Keyword	angolosamine
Note
Note (GenBank)
Reference	ACC Q7WT26 PmId [12855716] Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters. (Microbiology. , 2003)
Related Reference	ACC Q2PC67 NITE Rubra_00230 PmId [16614891] Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris. (Biotechnol Lett. , 2006)
Related Reference	ACC Q9F837 NITE Megalo_00050 PmId [16514147] In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea. (Microbiology. , 2006) [20418422] TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli. (Appl Environ Microbiol. , 2010)

Sequence

>putative NDP-hexose C-3 aminotransferase [NDP-deoxyhexose 3-aminotransferase]
MTTYVWDYLPEYENERDDLIDAVDTVFRSGRLILGPSVEGFESEFAAYHGLAHCAGVDNG
TNAVKLGLQALGVGPGDEVITVSNTAAPTVVAIDGTGATPVFVDIREQDFLMDTDQGAAA
ITPRTKVLLPVHLYGQCVDMAPLERLAAQHGLKILEDCAQSHGAHHHGRTAGTIGDAAAF
SFYPTKVLGAYGDAGAVVTDDPEVDAALRRLRYYGMAETYYVVQTPGHNSRLDEVQAEIL
RRKLRRLDTYIEGRRAVARRYEEGLGDLVAPDGLRLPVTAEGNDHVHYVYVVRHPRRDEI
IERLKGYGISLNISYPWPVHTMSGFAHLGYAPGSLPVTERLAGEIFSLPMYPSLSEDVQD
KVISALREVLTEGTRS

>putative NDP-hexose C-3 aminotransferase [NDP-deoxyhexose 3-aminotransferase]
ATGACCACCTACGTCTGGGACTACCTCCCGGAGTACGAGAACGAACGCGACGACCTCATC
GACGCGGTGGACACCGTCTTCCGCTCCGGCCGCCTCATCCTCGGCCCGTCGGTCGAGGGC
TTCGAGAGCGAGTTCGCCGCCTACCACGGCCTCGCGCACTGCGCCGGCGTGGACAACGGC
ACCAACGCCGTGAAGCTCGGCCTCCAGGCCCTCGGCGTCGGCCCCGGCGACGAGGTCATC
ACCGTCTCCAACACCGCCGCGCCCACCGTCGTCGCCATCGACGGCACCGGAGCCACCCCC
GTGTTCGTGGACATCCGCGAACAGGACTTCCTGATGGACACCGACCAGGGGGCGGCGGCC
ATCACCCCCCGGACCAAGGTCCTGCTGCCCGTCCACCTCTACGGCCAGTGCGTGGACATG
GCCCCGCTGGAGCGCCTCGCCGCACAGCACGGCCTGAAGATCCTCGAGGACTGCGCCCAG
TCGCACGGCGCCCACCACCACGGCCGGACGGCGGGCACCATCGGCGACGCCGCGGCCTTC
TCCTTCTACCCGACCAAGGTCCTCGGCGCGTACGGCGACGCCGGCGCGGTCGTCACCGAC
GACCCGGAGGTCGACGCCGCCCTGCGGCGCCTGCGCTACTACGGCATGGCGGAGACCTAC
TACGTCGTCCAGACCCCCGGACACAACTCCCGCCTCGACGAGGTGCAGGCCGAGATCCTC
CGGCGCAAGCTCCGCCGCCTCGACACCTACATCGAGGGCCGCCGGGCGGTCGCCCGCCGC
TACGAGGAGGGGCTCGGGGACCTCGTCGCGCCGGACGGGCTCCGGCTGCCCGTCACCGCC
GAGGGCAACGACCACGTCCACTACGTCTACGTCGTCCGCCACCCCCGGCGCGACGAGATC
ATCGAGCGGCTCAAGGGCTACGGCATCTCGCTGAACATCAGCTACCCCTGGCCGGTGCAC
ACGATGAGCGGCTTCGCACACCTCGGATACGCCCCGGGCTCGCTGCCCGTGACCGAGCGG
CTGGCCGGCGAGATCTTCTCCCTGCCGATGTACCCCTCGCTCTCCGAGGACGTCCAGGAC
AAGGTGATCTCCGCCCTGCGGGAGGTCCTCACCGAGGGGACCCGGTCATGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase (Family) PF01041 DegT_DnrJ_EryC1 PIRSF000390 PLP_StrS IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (Domain) G3DSA:3.40.640.10 PyrdxlP-dep_Trfase_major_sub1 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (Domain) G3DSA:3.90.1150.10 PyrdxlP-dep_Trfase_major_sub2 IPR015424 Pyridoxal phosphate-dependent transferase, major domain (Domain) SSF53383 PyrdxlP-dep_Trfase_major
SignalP	No significant hit
TMHMM	No significant hit

Medem_00150 Medem_00170

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