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Meili_00050
CDS information : Meili_00060
Location
| Organism | Streptomyces nanchangensis |
|---|---|
| Strain | NS3226 |
| Entry name | Meilingmycin |
| Contig | FJ952082 |
| Start / Stop / Direction | 17,425 / 10,556 / - [in whole cluster] 17,425 / 10,556 / - [in contig] |
| Location | complement(10556..17425) [in whole cluster] complement(10556..17425) [in contig] |
| Type | CDS |
| Length | 6,870 bp (2,289 aa) |
Annotation
| Category | 5.2 function unknown |
|---|---|
| Product | polyketide synthase |
| Product (GenBank) | modular polyketide synthase |
| Gene | |
| Gene (GenBank) | pks1 |
| EC number | |
| Keyword | |
| Note |
|
| Note (GenBank) | |
| Reference |
|
PKS/NRPS Module
Sequence
>polyketide synthase [modular polyketide synthase] MCIRRYSRRRYVYGSCSARFRPTVNRTGGSMQPGSTARLTPVAVIGLSPCLSGVAPTEAA LRALDNAGIVPERLREAAAGVFATEQTELIAAELGVNGPALTCDTLPAGVVHLACQSIHT GESALALAGVASPDGGNGFLVLKPVPAAVAEGDPIHCVIEGSALGRGDVVRQACARAGVE GDGIHFWWRGDYRAGGYHAADGLSGGGGEPGGRGEDAMAALLEMPVLLGRGRVPVPDARP DPERRLTAVHRSSDGAGVACALVLSEPPARPSPSARTAVPALPLLLSADSEETLCGKAES LRTHLTEPESPDILDAAHTLAVARPHLPYRAVVLGADRAELADGLGELALGRGGAGKADG GRKVAFLFPGEGGQRPGMGRELYPLFDVFADALDEVCAHMDAVATWSVRDLLLGTGNATA VAPADEALYTQDALFALQVALFRQFEDWGVRPDFVAGHSVGELAAATAAGVFSLPDVCAL LAERIRLFRERTPVGGAMVAMRISEAEALESLAGLEHLAGISAVNAPNSVVVSGDRETVL RIAGRWSERGRKVKQLPVDRAFHSPHMAAMAGDFEQFVRGLAPRPPRIPIVPVHNALGSD PGVVHLPEYWGAQVRGTGHFLHCVTSLDAAGVDTYVDMSANGVLAALVEETLPEPAAANA HITAALHGGGSDLRAVLGTLGGLHTHGVPVDWPAVFRGWGGRRIHLPTGVARPSRTASAV SRSTDLRRVIRTETEAMIEGGYGPDRSFLELGLDSLAAVQLVNRLRKRTGLKIATAALFD HPTPNRLAAHLENRTPRPVAARPRRTGPDEPIAITAMSCRFPAGVRSPEDLWRLLAEGRE VISPMPEDRGWDLAGLYDPERERPGTSYVRHGGFLHDAAEFDPAFFGIGGHEALEMDPQQ RLLLELTWEACERAGIDPATLRGSDTGVYAGLSYGHYGTGPGYADICLRPHLAIGTGAST ASGRISYTFGLNGPNLAIDTACSSSLVGLHLAAAALRRGECSLALAGAVTVLSSPMVFVE FSRQGGLAPDARAKPFAEGADGTAWAEGGGMFVLERYSDARRNGHPVLALIAGSAVNSDG ASNGFTAPNGAAQHRLLLSALADARLRPSDVDVVEAHGTGTMLGDPIEAGALLEAYGAHR PPDRPLLVGSLKSNLGHTQAAAGAAGVMKMVLAMRHGLVPATLNVDRPSPHVDWDAGLRL VTEDTPWPDQGPLRRAGVSSFGIGGTNAHVILQQPPAEPPAPAEPVRSVPPLWTVSGGSQ AALRAQAGQLAAHWDAHPDLDTRDIGFSLATTRSALTHRAVLTGGDRARLRRSLTALAAD RPDPDLTVGAVAEGGLAFLLTGQGSQRAGMGHGLYTAYPVFAEAFDEVCAGLGLPVKETV FGTDQKQLDRTEYAQTGLFAFQVALFRLLESWGIRPDLLLGHSLGGLTAAHLAGVLSLPD ACALVAARGSLMQALPEEGAMYAVAAGRDEVEELPPGVALAAVNGHRSVVISGAEEAVVA LAEGFRAQGRRTARLRVSHAFHSALMDPMLDAFLTVARSLTYHPPEIPVVSDLSGRLATA DELCSPEYWVSHVRGTVRFHDGMRTLHDEGVTTFLELGPDTTLTEMAADCLTETAEAAVV PALRQDDVLSAIAALQVRGHGPDWSRWYAGSGARRVDLPTYAFQRKRFWLLPDAAAGRPQ PTDREAAMDRLRYRIGWQPTADRTASPRNWLIVHADTLPVPQPLGATLGSRTLPLAIDAD RTKIAESLVTASNGEPIDGVLSLLALEERTHPGTPGVPGGLALTTALIQAMGDAGLEAPL WCATQGAVSTGHGDRLGNPAQAMVWGLGRVAALEHPGRWGGLVDLPATLDAPAAERLAGI LSSTEDQAAIRATGVFVRRLLRAPLPTEPRREWPVRGTTLITGAFGALGRRVAKWLAAEG AERLLLTGRHADDPELVAELTALGTEVDTAVCDVGDREAVAALLARIPEDRPLTAVAHAA GVLDDGVIEALDPQRLARALHAKATGAKNLHELAGELRAFILFSSATGAVGNAGQANYAA ANTYLDALAEQRRADGLAATSMAWGPWGAGGMAVDGTDAQIVGTRLRRNGMTVLDPDLAI AVLARAYAHDESGLVIADIDWTRFLSALATTRNSPLFMDLPEAQQSKAAPPPSEISALVQ RLAGMSRAECVRTLRDLVCENTAQLLGHDSATQIQPAKPFHEQGLSSLGIVELRNQLSAQ TGLRMPASVLFDHPTPSALAGHLATELAPDTAPPDRTPPEAEPGTTDLEAILSLAEQELS RAGEDRHDG
>polyketide synthase [modular polyketide synthase] CTGTGTATTCGGCGGTATTCCCGTCGGCGATACGTGTACGGCTCGTGTTCGGCACGATTC CGCCCGACGGTGAACAGGACAGGTGGTTCCATGCAGCCCGGAAGTACCGCTCGCCTGACG CCAGTCGCGGTCATCGGCTTGTCTCCGTGCCTGTCGGGGGTCGCGCCCACCGAGGCGGCG CTGCGGGCGCTGGACAACGCCGGTATCGTCCCGGAACGGCTCCGGGAGGCGGCGGCCGGA GTGTTCGCCACCGAGCAGACCGAGCTGATCGCCGCCGAACTGGGTGTGAACGGGCCCGCG TTGACGTGCGACACCCTCCCCGCCGGTGTGGTCCACCTGGCCTGCCAGAGTATCCACACG GGCGAGTCCGCGCTCGCGCTCGCCGGGGTCGCCTCACCGGATGGCGGCAACGGATTCCTC GTACTCAAGCCGGTTCCGGCAGCGGTGGCCGAAGGCGACCCGATCCACTGTGTGATCGAG GGCAGCGCACTGGGCCGCGGTGACGTCGTACGGCAGGCCTGTGCGCGCGCCGGGGTGGAG GGCGACGGGATCCACTTCTGGTGGCGCGGCGACTACCGGGCGGGTGGCTACCACGCGGCG GACGGCCTGTCCGGCGGTGGTGGCGAACCGGGCGGCCGGGGCGAGGACGCGATGGCGGCG CTGCTGGAGATGCCCGTGCTGCTGGGCCGCGGCCGGGTTCCGGTCCCAGACGCCCGGCCC GACCCCGAGCGCCGTCTCACCGCGGTCCACCGTTCCTCCGACGGCGCGGGAGTGGCCTGC GCGTTGGTGCTGTCGGAGCCGCCCGCGCGCCCGTCGCCGTCGGCGCGGACCGCGGTCCCG GCGCTGCCGTTGCTGCTGTCGGCGGACAGCGAAGAGACGCTGTGCGGCAAGGCGGAGAGC CTGCGCACCCATCTGACCGAACCGGAGAGCCCGGACATCCTCGATGCCGCGCACACCCTG GCGGTCGCCAGGCCACATCTGCCGTATCGCGCGGTGGTCCTCGGCGCCGACCGCGCCGAA CTCGCCGACGGGCTCGGGGAACTCGCCCTGGGGCGAGGCGGCGCGGGGAAGGCCGACGGC GGGCGCAAGGTGGCCTTCCTCTTTCCCGGCGAGGGCGGGCAGCGGCCGGGCATGGGGCGC GAGCTGTACCCGCTGTTCGACGTGTTCGCCGACGCGCTCGACGAGGTGTGCGCCCACATG GACGCGGTCGCCACCTGGTCGGTGCGTGATCTGCTGCTCGGTACGGGCAACGCCACCGCG GTCGCGCCGGCCGACGAGGCCCTGTATACCCAGGACGCGCTGTTCGCGCTTCAGGTGGCG CTGTTCCGGCAGTTCGAGGACTGGGGCGTACGCCCGGACTTCGTGGCCGGGCACTCGGTC GGGGAACTGGCCGCGGCGACGGCGGCCGGGGTGTTCTCCCTGCCCGACGTATGCGCGCTG CTCGCCGAGCGGATCCGGCTGTTCCGGGAGAGGACACCGGTCGGCGGCGCGATGGTCGCC ATGCGGATCTCCGAGGCCGAGGCCTTGGAATCGCTGGCCGGTCTTGAGCATCTGGCCGGC ATCTCCGCTGTGAACGCTCCGAACTCCGTCGTCGTCTCCGGCGACCGCGAAACCGTGCTG CGGATCGCCGGACGGTGGTCCGAGCGGGGACGCAAGGTCAAACAGCTGCCGGTCGACCGG GCTTTCCACTCACCGCATATGGCTGCGATGGCCGGCGACTTCGAGCAATTCGTCCGCGGC CTCGCCCCGCGACCGCCGCGCATTCCGATTGTTCCGGTGCACAACGCGCTGGGATCAGAC CCCGGTGTCGTCCACCTGCCCGAATATTGGGGGGCGCAGGTGCGCGGCACCGGGCATTTT CTCCACTGCGTGACCAGCCTCGACGCGGCCGGCGTGGACACCTATGTGGACATGAGCGCG AACGGAGTGCTGGCGGCGCTGGTCGAGGAGACCCTGCCCGAGCCCGCCGCCGCGAACGCG CATATCACCGCCGCGCTGCACGGCGGCGGGTCCGATCTGCGCGCCGTGCTCGGCACACTG GGCGGACTGCACACCCATGGTGTCCCGGTGGACTGGCCCGCCGTCTTCCGCGGCTGGGGT GGCCGGCGTATCCATCTGCCGACCGGCGTGGCACGGCCCTCCCGTACCGCATCCGCCGTA TCCCGGTCGACGGATCTGCGGCGGGTGATCAGGACCGAGACCGAGGCGATGATCGAGGGC GGCTACGGGCCGGACCGGTCGTTCCTCGAGCTCGGGCTCGACTCCCTCGCCGCCGTGCAG TTGGTGAACCGGCTGCGGAAGCGGACCGGGCTGAAGATCGCCACAGCCGCGCTCTTCGAC CACCCGACTCCGAACCGACTGGCCGCACATCTGGAGAACCGCACACCCCGGCCGGTGGCT GCCCGCCCCCGCCGGACCGGCCCGGACGAGCCGATCGCCATCACCGCGATGAGCTGCCGG TTCCCGGCAGGGGTGCGCTCGCCGGAGGACCTGTGGCGGTTGCTCGCCGAAGGCCGTGAG GTCATATCGCCGATGCCGGAGGACCGCGGCTGGGACCTGGCCGGGCTGTACGACCCGGAG CGCGAACGCCCGGGTACGAGCTATGTGCGCCACGGCGGATTTCTCCACGACGCCGCCGAG TTCGACCCCGCGTTCTTCGGCATCGGCGGACACGAAGCACTGGAGATGGACCCGCAGCAG CGGCTGCTGCTCGAACTGACCTGGGAAGCGTGTGAACGGGCCGGTATCGACCCGGCCACC CTCCGCGGCAGCGACACCGGGGTCTACGCCGGGCTGTCATACGGCCACTACGGCACCGGC CCCGGGTACGCGGACATCTGCCTGCGACCGCATCTGGCGATCGGCACCGGGGCCAGCACG GCCTCCGGCCGGATCTCGTACACCTTCGGGCTGAACGGGCCCAATCTCGCCATCGACACG GCGTGTTCGTCCTCACTGGTCGGGCTCCATCTCGCCGCCGCCGCGCTGCGCCGTGGCGAG TGTTCGCTGGCGCTGGCGGGCGCGGTGACCGTGCTGTCGTCGCCCATGGTGTTCGTCGAG TTCAGCCGCCAGGGCGGGCTCGCCCCCGACGCGCGGGCGAAACCCTTCGCCGAGGGCGCC GACGGCACCGCCTGGGCCGAAGGGGGTGGCATGTTCGTCCTGGAGCGGTACTCCGACGCG CGCCGCAACGGCCATCCGGTGCTCGCCCTGATCGCGGGCTCGGCGGTCAACTCCGACGGC GCGAGCAACGGGTTCACCGCGCCCAACGGCGCCGCCCAGCACCGGCTGCTGCTCTCCGCG CTCGCCGACGCCCGGCTGCGACCGTCCGACGTGGACGTCGTGGAGGCTCACGGCACCGGG ACGATGCTCGGCGACCCGATCGAAGCCGGTGCCCTCCTGGAGGCCTACGGCGCGCACCGG CCGCCGGACCGCCCACTGCTGGTGGGCTCGCTCAAGTCCAACCTGGGCCACACCCAGGCC GCGGCCGGCGCGGCAGGGGTGATGAAGATGGTGCTCGCCATGCGGCACGGGCTGGTCCCG GCGACCCTGAACGTCGACAGGCCCAGCCCGCACGTGGACTGGGACGCCGGGCTGCGGCTG GTGACCGAGGACACGCCCTGGCCCGACCAGGGCCCGCTCCGGCGGGCGGGCGTGTCGTCG TTCGGGATCGGCGGGACCAACGCCCACGTCATCCTTCAGCAGCCGCCCGCCGAACCACCG GCTCCGGCGGAGCCCGTACGGAGCGTCCCTCCCCTGTGGACCGTCTCCGGCGGCTCACAG GCCGCCCTGCGCGCCCAGGCCGGACAACTCGCCGCACACTGGGACGCCCATCCCGATCTC GACACGCGCGACATCGGCTTCTCGCTGGCCACGACGCGCTCGGCCCTGACCCACCGAGCC GTCCTCACCGGCGGCGACCGCGCCCGGCTGCGGCGCTCACTGACCGCGCTGGCGGCGGAC CGGCCCGACCCCGATCTCACGGTCGGCGCGGTGGCGGAAGGCGGCCTGGCCTTTCTGCTG ACCGGTCAGGGCAGCCAGCGGGCGGGCATGGGACACGGGCTGTACACGGCGTACCCGGTC TTCGCCGAGGCCTTCGACGAGGTGTGCGCCGGGCTGGGCCTGCCGGTGAAGGAGACGGTG TTCGGCACGGACCAGAAACAACTGGACCGGACCGAGTACGCGCAGACCGGGCTGTTCGCC TTCCAGGTGGCGCTGTTCCGGCTGCTCGAAAGCTGGGGCATCCGGCCGGACCTGCTGCTG GGACACTCCCTCGGTGGGCTGACCGCCGCCCATCTGGCCGGGGTCCTGTCCCTGCCGGAC GCATGCGCACTGGTCGCGGCGCGTGGCTCGCTCATGCAGGCGCTGCCCGAAGAAGGGGCG ATGTACGCGGTGGCGGCCGGGCGGGACGAGGTCGAGGAGCTGCCGCCGGGAGTGGCGTTG GCGGCGGTGAACGGCCACCGGTCGGTGGTGATCTCCGGTGCCGAGGAGGCGGTCGTCGCG CTGGCGGAGGGGTTCCGCGCCCAGGGCCGCAGGACCGCGCGCCTGCGGGTCAGCCACGCG TTCCACTCCGCCTTGATGGATCCCATGCTCGACGCGTTCCTCACGGTCGCCCGGAGCCTG ACGTACCATCCGCCGGAGATCCCCGTCGTCTCCGATCTGTCCGGGCGGCTCGCCACGGCC GACGAGTTGTGTTCCCCCGAGTACTGGGTCAGCCATGTGCGCGGCACGGTCCGCTTCCAC GACGGGATGCGGACCCTGCACGACGAGGGCGTCACCACCTTCCTGGAGCTGGGACCTGAC ACCACGCTCACCGAGATGGCCGCCGACTGCCTCACGGAAACCGCCGAGGCGGCGGTGGTC CCCGCCCTGCGCCAGGACGATGTGCTCAGCGCCATCGCGGCGTTGCAGGTACGTGGCCAC GGGCCCGACTGGTCGCGGTGGTACGCCGGAAGCGGGGCCCGGCGCGTGGACCTGCCCACG TACGCCTTCCAGCGCAAGCGGTTCTGGCTGCTGCCCGACGCGGCCGCGGGCCGCCCCCAG CCGACGGACCGGGAAGCCGCGATGGACCGGCTGCGGTACCGGATCGGCTGGCAGCCCACG GCGGACCGGACCGCCTCCCCGCGCAACTGGCTGATCGTCCACGCCGACACCCTCCCCGTG CCGCAACCCCTCGGCGCCACGCTCGGCTCCCGGACACTGCCGCTCGCCATCGACGCGGAC CGCACGAAGATCGCCGAGAGCCTTGTGACCGCGTCGAACGGCGAACCGATCGACGGGGTG CTGTCCCTGCTGGCGCTGGAGGAGCGGACTCATCCGGGCACACCCGGCGTACCCGGAGGA CTCGCGCTGACCACGGCGCTCATCCAGGCCATGGGCGACGCCGGCCTCGAAGCGCCCCTG TGGTGCGCGACGCAGGGCGCGGTGTCCACGGGCCACGGCGACCGGCTCGGTAACCCGGCG CAGGCCATGGTGTGGGGGCTGGGCCGGGTCGCGGCGCTCGAACACCCCGGACGGTGGGGC GGACTGGTCGACCTCCCCGCCACCCTCGACGCACCAGCGGCCGAACGGCTCGCCGGGATA CTCTCCTCGACCGAAGACCAGGCCGCCATCCGCGCCACAGGAGTGTTCGTCCGGCGACTG CTGCGCGCACCGCTGCCCACCGAACCCCGGCGCGAGTGGCCCGTACGCGGAACCACCCTC ATCACCGGAGCGTTCGGCGCACTGGGCAGACGCGTCGCGAAGTGGCTGGCCGCCGAAGGC GCCGAACGGCTGCTCCTGACGGGCCGGCACGCCGACGACCCCGAACTGGTCGCCGAGCTG ACCGCGCTCGGCACCGAGGTGGACACCGCCGTCTGCGACGTGGGCGACCGGGAAGCGGTG GCAGCCCTGCTCGCGCGCATCCCCGAGGACCGCCCGCTGACCGCGGTGGCGCACGCCGCC GGGGTGCTCGACGACGGCGTGATCGAAGCGCTGGACCCCCAGCGGCTCGCACGCGCCCTG CACGCCAAGGCCACCGGCGCCAAGAACCTCCACGAGCTGGCGGGGGAGCTGCGGGCGTTC ATACTGTTCTCCTCCGCCACCGGCGCGGTCGGCAACGCCGGCCAGGCCAACTACGCGGCG GCCAACACCTACCTCGACGCGCTCGCCGAACAGCGCCGCGCCGATGGACTCGCGGCCACG TCGATGGCCTGGGGGCCGTGGGGGGCCGGTGGCATGGCGGTGGACGGCACGGACGCACAG ATCGTGGGCACGCGGCTGCGCCGCAACGGCATGACGGTGCTCGACCCGGACCTGGCGATC GCCGTACTGGCCCGGGCCTACGCACACGACGAATCCGGGCTCGTGATCGCGGACATCGAC TGGACGCGATTCCTCTCGGCGCTCGCCACCACCCGCAACAGCCCGCTGTTCATGGACCTG CCCGAGGCCCAGCAGAGCAAGGCTGCCCCGCCACCCTCGGAGATCTCCGCGCTCGTACAG CGGCTCGCCGGGATGTCGCGGGCCGAGTGTGTCCGTACGCTGCGCGATCTGGTGTGCGAG AACACCGCGCAGCTGCTCGGGCACGACTCGGCCACGCAGATCCAGCCCGCGAAACCCTTC CATGAGCAAGGGCTCAGCTCGCTGGGCATCGTCGAACTGCGCAACCAGCTCAGCGCGCAG ACCGGGCTGCGGATGCCCGCCAGTGTGCTGTTCGACCATCCCACCCCCTCCGCGCTGGCC GGCCACCTCGCCACGGAGCTCGCCCCGGACACCGCTCCACCCGACCGCACACCACCGGAG GCGGAGCCCGGGACGACCGATCTCGAGGCCATCCTGAGCCTCGCCGAACAGGAACTCTCC CGGGCCGGGGAGGACCGCCACGATGGCTGA
Feature
| BLASTP Database:UniProtKB:2010_04 |
|
|---|---|
| InterPro Database:interpro:26.0 |
IPR001227 Acyl transferase domain (Domain)
IPR006162 Phosphopantetheine attachment site (PTM)
IPR006163 Phosphopantetheine-binding (Domain)
IPR009081 Acyl carrier protein-like (Domain)
IPR013968 Polyketide synthase, KR (Domain)
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
IPR014043 Acyl transferase (Domain)
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
IPR016038 Thiolase-like, subgroup (Domain)
IPR016039 Thiolase-like (Domain)
IPR016040 NAD(P)-binding domain (Domain)
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
IPR020806 Polyketide synthase, phosphopantetheine-binding (Domain)
IPR020841 Polyketide synthase, beta-ketoacyl synthase region (Region)
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
|
| SignalP |  ![[1-1] Signal-anchor](/pks/img/M.gif "[1-1] Signal-anchor"){kind=small} |
| TMHMM | No significant hit |
![[362-654] 2.7e-54 G3DSA:3.40.366.10](/pks/img/X2.gif "[362-654] 2.7e-54 G3DSA:3.40.366.10"){kind=small}
![[750-765] PS00012](/pks/img/P.gif "[750-765] PS00012"){kind=small}
![[728-791] 5e-14 PF00550](/pks/img/H.gif "[728-791] 5e-14 PF00550"){kind=small}
![[719-826] 1.1e-22 SSF47336](/pks/img/B.gif "[719-826] 1.1e-22 SSF47336"){kind=small}
![[367-670] 1.1e-78 SM00827](/pks/img/R.gif "[367-670] 1.1e-78 SM00827"){kind=small}
Advanced search
KS seq Analysis 
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