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CDS information : Monen_00210


close this sectionLocation

Organism
StrainATCC 15413
Entry nameMonensin
Contig
Start / Stop / Direction72,051 / 74,993 / + [in whole cluster]
72,051 / 74,993 / + [in contig]
Location72051..74993 [in whole cluster]
72051..74993 [in contig]
TypeCDS
Length2,943 bp (980 aa)
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close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative LuxR family transcriptional regulator
Product (GenBank)putative regulatory protein
Gene
Gene (GenBank)monH
EC number
Keyword
Note
Note (GenBank)
  • contains helix-turn-helix motif; similar to RapH; MonH
Reference
ACC
PmId
[12940979] Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. (Mol Microbiol. , 2003)
Related Reference
ACC
Q9ZGI0
NITE
Pikro_00180
PmId
[11344155] Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. (J Bacteriol. , 2001)
[18245260] Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae. (Appl Environ Microbiol. , 2008)
[26608164] Interspecies Complementation of the LuxR Family Pathway-Specific Regulator Involved in Macrolide Biosynthesis. (J Microbiol Biotechnol. , 2016)

close this sectionSequence

selected fasta
>putative LuxR family transcriptional regulator [putative regulatory protein]
MSGVERGVGSAGPVEQGDGLAGLVERAEALAALRGAFDGSPGTGGSLVVLSGAVGTGKTA
LLRAWADRIGADADALVLTATACRAERDLPLGVLEQLVRSPGLPPASAERALAWWDEEAS
ATPGKTDANGTSANGTDANGTGAGQTGAGQAGVGQTGVGGEPVLAASALRGLCEVLRDLL
AERPVVVAVDDAHHADAASLQCLLSVVRRLRSARLHVLFTEYAHQKAQNALLSSEFLHEP
ALRRIRLEPLSKAGVEALLARHLDERTAQDLTPVVHGMSAGHPLLVRALAEDHRAAGGAG
EAYGRAVLSFLYRHETPVTQVARAIAALGAHAGPGQVGRLLDVDAASVERAVRQLTVAEV
LHEGRLCHPAFAAAVLDGMPPEERRALHGRVADLLHEEGAPATEVAAHLVAADRSDAPWA
VPVFQEAAQLALDEDQVETGVDYLRAAHQRCRGAAQRAAVVGALADAEWRLDPAKVLRHL
PDPAAMAPQTDPAALAPHTDPAPTAAPTAAPTPTPIPTTPPLPTHLLWHGRVEEGLDAIG
TLTGPGPNPAGAPPMNPADLDTPWLWGAYLYPGHVKERLGSGALSPQRSTPPAVTPELQG
AGTLMNDLLHGGERDATEAAERALNRYRLGPRTIAVQTAALAALTYRDRPHRAAAWCDGL
VAQADERNSPTWRALFTAWRALLHLRQGDPAAAEQRAETALALLGSKGWGAAIGLPLAAA
VQAKAALGDVDGAAALLERPVPQAVFQTRTGLHYLAARGRYHLATGCHYAALCDFYACGT
RMSSWGVDLPALEPWRLGAAEAYLALGEGLLARQLVDGQLPLPTPDDGRTWGMTLRLRAA
TSPAPARAELLDEAVAVLRESGDTFELARAVADQAVAVREGGEAERARLLARKAELLARR
WGSAPAPATVPEPPERPGPATPDAELTSAERRVAELAAEGFTNREISRKLCVTVSTVEQH
LTRIYRKLDVRRLDLQAALG
selected fasta
>putative LuxR family transcriptional regulator [putative regulatory protein]
GTGAGCGGGGTGGAGCGGGGTGTGGGGTCGGCGGGCCCTGTGGAACAGGGTGACGGACTC
GCGGGCCTGGTCGAGCGGGCCGAGGCGCTGGCCGCTCTGCGGGGCGCCTTCGACGGCTCC
CCGGGCACCGGCGGCAGCCTCGTCGTGCTCAGCGGCGCGGTGGGCACCGGCAAGACCGCG
CTGCTACGGGCGTGGGCCGACCGCATCGGCGCCGATGCCGACGCCCTGGTCCTGACCGCC
ACCGCCTGCCGCGCCGAGCGCGACCTGCCGCTTGGCGTCCTGGAACAGCTGGTACGCAGC
CCCGGCCTGCCCCCGGCCAGCGCCGAGCGCGCGCTGGCGTGGTGGGACGAGGAGGCCTCG
GCCACCCCCGGAAAGACGGACGCGAACGGGACGAGTGCCAACGGGACGGACGCCAACGGG
ACGGGCGCGGGACAGACGGGCGCGGGGCAGGCGGGCGTGGGACAGACGGGCGTGGGCGGA
GAGCCCGTCCTGGCCGCCTCCGCCCTGCGAGGCCTGTGCGAGGTGCTGCGGGACCTGCTC
GCCGAGCGGCCCGTCGTGGTCGCCGTCGACGACGCGCACCATGCCGACGCGGCGTCGCTC
CAGTGCCTGCTCTCCGTGGTGCGCCGGCTGCGGTCGGCACGACTCCATGTGCTGTTCACC
GAGTACGCCCATCAGAAGGCGCAGAACGCCCTGCTGAGCAGCGAGTTCCTGCACGAGCCC
GCCCTGCGGCGGATCCGCCTGGAACCGCTGTCGAAGGCGGGCGTGGAGGCCTTGCTCGCC
CGGCACCTCGACGAGCGGACGGCACAAGACCTCACCCCCGTCGTCCACGGCATGAGCGCG
GGCCACCCGCTCCTCGTACGGGCGCTGGCCGAGGACCACCGTGCGGCGGGCGGCGCCGGG
GAGGCGTACGGTCGTGCCGTCCTCAGCTTTCTGTACCGGCACGAGACTCCGGTCACCCAA
GTCGCCCGCGCCATCGCTGCGTTGGGCGCGCACGCCGGACCCGGTCAGGTCGGGCGGCTG
CTCGATGTCGACGCGGCGTCCGTCGAGCGGGCCGTGCGGCAGCTGACCGTCGCGGAGGTG
CTGCACGAGGGCCGCCTGTGCCACCCGGCGTTCGCGGCGGCGGTCCTGGACGGCATGCCG
CCCGAGGAACGCCGCGCCCTGCACGGACGGGTCGCCGACCTCCTGCACGAGGAGGGGGCG
CCGGCCACCGAAGTGGCCGCCCACCTCGTCGCCGCCGACCGGTCCGACGCCCCGTGGGCG
GTACCCGTCTTCCAGGAAGCGGCCCAACTCGCCCTGGACGAGGACCAGGTGGAGACCGGC
GTCGACTATCTGCGCGCGGCCCACCAGCGGTGCCGGGGCGCCGCGCAGCGTGCCGCGGTC
GTCGGTGCGCTCGCCGACGCCGAGTGGCGGCTCGACCCAGCAAAGGTCCTGCGCCACCTG
CCCGACCCTGCAGCCATGGCCCCACAAACGGACCCTGCCGCCCTGGCCCCACACACGGAC
CCCGCACCCACAGCCGCACCCACAGCCGCCCCCACCCCCACCCCCATCCCGACCACCCCA
CCCCTCCCCACCCACCTGCTCTGGCACGGGCGGGTCGAGGAAGGCCTGGACGCCATCGGC
ACGCTCACCGGGCCCGGACCCAACCCGGCGGGTGCGCCGCCGATGAACCCCGCGGACCTG
GACACCCCATGGCTGTGGGGCGCCTACCTCTATCCCGGGCACGTCAAGGAGCGCCTGGGA
TCCGGCGCCCTGTCCCCGCAGCGCTCGACCCCGCCGGCGGTCACGCCGGAGCTCCAAGGC
GCGGGCACGCTGATGAACGACCTGCTGCACGGCGGCGAACGCGACGCCACCGAGGCCGCC
GAGCGCGCCCTCAACCGCTACCGGCTCGGCCCCCGCACCATCGCGGTCCAGACGGCCGCG
CTGGCCGCCCTCACCTACCGCGACCGGCCGCACCGCGCGGCCGCCTGGTGCGACGGCCTC
GTCGCCCAGGCCGACGAGCGCAACAGCCCCACCTGGCGGGCCCTGTTCACCGCGTGGCGT
GCCCTGCTCCACCTGCGGCAGGGCGACCCGGCCGCAGCGGAACAGCGCGCCGAAACCGCC
CTCGCCCTGCTCGGATCGAAGGGCTGGGGCGCCGCGATCGGCCTGCCGCTGGCAGCCGCC
GTACAGGCCAAGGCGGCCCTCGGCGATGTCGACGGGGCGGCGGCCCTCCTGGAACGGCCC
GTGCCCCAGGCGGTCTTCCAGACCCGCACCGGACTGCACTACCTGGCGGCCCGGGGCCGC
TATCACCTCGCCACCGGCTGCCACTACGCCGCACTGTGCGACTTCTACGCCTGCGGGACC
CGCATGAGCAGCTGGGGAGTGGACCTGCCCGCGCTGGAGCCGTGGCGCCTCGGCGCGGCG
GAAGCGTACCTGGCCCTCGGCGAAGGACTCCTGGCACGCCAACTCGTCGACGGCCAGCTG
CCGTTGCCCACGCCTGACGACGGCCGCACCTGGGGCATGACGTTGCGCCTGCGGGCGGCC
ACGTCCCCCGCGCCGGCCCGGGCCGAACTCCTCGACGAGGCCGTGGCGGTGCTCCGGGAG
AGCGGCGACACCTTCGAGCTGGCGCGGGCCGTCGCCGACCAGGCTGTTGCCGTACGCGAA
GGGGGCGAGGCGGAACGCGCCCGGCTGCTGGCCCGCAAGGCGGAGCTGCTGGCCCGGCGC
TGGGGCAGCGCCCCCGCGCCCGCCACCGTCCCCGAACCGCCGGAGCGGCCAGGACCGGCC
ACTCCGGACGCCGAACTGACCAGTGCGGAGCGGAGGGTGGCCGAGCTGGCCGCCGAAGGG
TTCACCAACCGGGAGATCTCCCGGAAGCTGTGCGTCACGGTCAGCACCGTGGAACAGCAC
CTGACCCGGATCTACCGGAAGCTCGACGTCAGGCGACTGGACCTCCAGGCAGCCCTCGGC
TGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [926-940]  1e-08 PR00038 [940-956]  1e-08 PR00038 [956-968]  1e-08 PR00038
PR00038   HTHLUXR
 [923-979]  3.69999438558106e-18 SM00421
SM00421   HTH_LUXR
 [940-967]  PS00622
PS00622   HTH_LUXR_1
 [924-971]  9.8e-12 PF00196
PF00196   GerE
 [919-980]  PS50043
PS50043   HTH_LUXR_2
IPR003593 AAA+ ATPase domain (Domain)
 [44-251]  4.19999771339581e-06 SM00382
SM00382   AAA
IPR011990 Tetratricopeptide-like helical (Domain)
 [615-760]  2.2e-08 G3DSA:1.25.40.10 [761-936]  2.2e-08 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [937-972]  1.9e-15 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [904-971]  6.29999562859499e-15 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP
 [1-29]  0.183 Signal
Bacteria, Gram-positive   
TMHMM No significant hit