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CDS information : Nogl_00310


close this sectionLocation

Organism
StrainATCC 27451 (=NBRC 13445)
Entry nameNogalamycin
Contig
Start / Stop / Direction31,905 / 31,300 / - [in whole cluster]
3,203 / 2,598 / - [in contig]
Locationcomplement(31300..31905) [in whole cluster]
complement(2598..3203) [in contig]
TypeCDS
Length606 bp (201 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category2.3 modification addition of sugar moiety
Productputative NDP-hexose epimerase
Product (GenBank)SnogF
Gene
Gene (GenBank)snogF
EC number5.1.3.-
Keyword
  • nogalamine
  • nogalose
Note
Note (GenBank)
Reference
ACC
PmId
[9349712] Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis. (Mol Gen Genet. , 1997)
Related Reference
ACC
O33707
NITE
Adria_00190
PmId
[9209071] Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine. (J Bacteriol. , 1997)
[10631513] A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D. (Chem Biol. , 1999)
[11129052] Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea. (Mol Gen Genet. , 2000)
[15977277] An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose. (Chembiochem. , 2005)
ACC
Q9S0P2
NITE
Aver_00150
PmId
[11451669] Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. (Chem Biol. , 2001)

close this sectionSequence

selected fasta
>putative NDP-hexose epimerase [SnogF]
MESRTLLVEGAHAFTPRVFPDARGCFVSPFQQTPVAEALGHRLFPVAQTNHSRSRRGVVR
GAHFTLTPPGIAKYVYCARGRARDYVIDIRVGSPTFGQWDSVVLDDRNFRAMYFPVGVAH
AFAALEDDTVMSYMLSGEYVADNELALSVFDPDLALELPGDTPLLLSERDTAAPTLRELE
SDGRLPRYEECVKLEHDLYAG
selected fasta
>putative NDP-hexose epimerase [SnogF]
ATGGAGTCACGCACGCTTCTCGTCGAGGGCGCCCACGCGTTCACGCCCCGGGTCTTCCCC
GACGCCCGCGGATGCTTCGTCTCACCGTTCCAGCAGACCCCGGTGGCCGAGGCGCTCGGC
CACCGGCTGTTTCCCGTGGCCCAGACCAATCACAGCCGGTCGCGGCGCGGCGTGGTACGC
GGAGCGCACTTCACCCTCACCCCGCCGGGCATCGCCAAGTACGTCTACTGCGCCCGGGGA
CGGGCTCGCGACTACGTCATCGACATCCGTGTCGGCTCACCCACCTTCGGTCAGTGGGAC
TCGGTCGTCCTGGACGACCGGAACTTTCGCGCCATGTACTTCCCGGTCGGCGTGGCCCAC
GCCTTCGCCGCCCTGGAGGACGACACGGTGATGTCCTACATGCTCTCCGGCGAGTACGTG
GCGGACAACGAACTGGCCCTGTCCGTCTTCGACCCCGATCTCGCCCTCGAACTTCCCGGG
GACACGCCGTTGTTGCTCTCCGAGCGCGACACGGCGGCACCGACGCTCAGGGAACTGGAG
TCGGACGGCCGGCTGCCGCGCTACGAGGAGTGCGTCAAGCTCGAACACGACCTGTACGCC
GGATGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related (Family)
 [1-178]  PD001462
PD001462   dTDP_sugar_isom
 [6-178]  4.10000000000004e-53 PF00908
PF00908   dTDP_sugar_isom
IPR011051 RmlC-like cupin domain (Domain)
 [1-183]  2.30000440726534e-64 SSF51182
SSF51182   RmlC_like_cupin
IPR014710 RmlC-like jelly roll fold (Domain)
 [1-191]  4.6e-56 G3DSA:2.60.120.10
G3DSA:2.60.120.10   RmlC-like_jellyroll
SignalP No significant hit
TMHMM No significant hit