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CDS information : Nysta_00110

Location

Organism	Streptomyces noursei
Strain	ATCC 11455 (=NBRC 14542)
Entry name	Nystatin
Contig	AF263912
Start / Stop / Direction	60,888 / 59,830 / - [in whole cluster] 60,888 / 59,830 / - [in contig]
Location	complement(59830..60888) [in whole cluster] complement(59830..60888) [in contig]
Type	CDS
Length	1,059 bp (352 aa)

Annotation

Category	2.3 modification addition of sugar moiety
Product	putative GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase
Product (GenBank)	NysDII
Gene
Gene (GenBank)	nysDII
EC number
Keyword	mycosamine
Note
Note (GenBank)	putative aminotransferase
Reference	ACC Q9L4W7 PmId [10873841] Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. (Chem Biol. , 2000) [17905880] Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455. (Appl Environ Microbiol. , 2007)
Related Reference	ACC Q93NX0 NITE Amph_00130 PmId [16079135] Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups. (J Biol Chem. , 2005)
Related Reference	ACC Q6W5Q8 NITE FR008_00080 PmId [14652074] Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. (Chem Biol. , 2003)

Sequence

>putative GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase [NysDII]
MSFTYPVSMPWLQGRELDYVTEAVGGGWISSQGPYVRRFEEAFAAYNDVPFGVACSSGTT
ALTLALRALGVGPGDEVIVPEFTMIASAWAVTYTGATPVFVDCGDDLNIDVSRIEEKITP
RTKVIMPVHIYGRQCDMDAVLNLAYEYNLRVVEDSAEAHGVRPRGDIACFSLFANKIISA
GEGGVCLTHDPHLAEQMAHLRAMAFTKDHSFLHKKLAYNFRMTNMQAAVALAQTEQLDTI
LALRRDIEKRYDEALRDIPGITLMPPRDVLWMYDLRAERRDELCAYLAGEGIETRVFFKP
MSRQPGYFSADWPALNAARLSADGFYLPTHTGLTAQEQEFITGRIRAFYGVA

>putative GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase [NysDII]
ATGTCCTTTACGTATCCGGTGTCCATGCCGTGGCTCCAGGGCCGCGAGCTCGACTATGTG
ACGGAGGCCGTCGGCGGCGGCTGGATCTCTTCGCAGGGGCCGTACGTCAGGCGGTTCGAG
GAGGCGTTCGCCGCGTACAACGACGTGCCGTTCGGCGTCGCCTGCTCCTCCGGCACCACG
GCGCTGACGCTGGCGCTGCGCGCGCTGGGCGTCGGCCCCGGTGACGAGGTGATCGTCCCG
GAGTTCACGATGATCGCGTCCGCCTGGGCGGTGACCTACACCGGTGCCACGCCGGTGTTC
GTGGACTGCGGCGACGACCTGAACATCGACGTGTCCCGCATCGAGGAGAAGATCACCCCG
CGCACCAAAGTGATCATGCCGGTGCACATCTACGGCCGGCAGTGCGACATGGACGCCGTG
CTGAACCTGGCGTACGAGTACAACCTGCGGGTGGTGGAGGACTCCGCCGAGGCGCACGGG
GTGCGGCCGCGGGGCGACATCGCCTGTTTCTCGCTCTTCGCCAACAAGATCATCTCGGCC
GGCGAGGGCGGCGTCTGCCTGACCCACGACCCGCACCTGGCCGAGCAGATGGCCCATCTG
CGGGCGATGGCGTTCACCAAGGACCACAGCTTCCTGCACAAGAAGCTGGCCTACAACTTC
CGGATGACCAACATGCAGGCCGCGGTGGCGCTCGCGCAGACCGAGCAGCTGGACACCATC
CTCGCCCTGCGCCGCGACATCGAGAAGCGCTACGACGAGGCGCTGCGCGACATCCCCGGC
ATCACGCTGATGCCGCCGCGCGACGTGCTGTGGATGTACGACCTGCGGGCCGAGCGGCGG
GACGAGCTGTGCGCGTACCTCGCCGGCGAGGGCATCGAGACCCGGGTCTTCTTCAAGCCG
ATGAGCCGTCAGCCCGGTTACTTCTCCGCCGACTGGCCCGCGTTGAACGCGGCCCGGCTC
AGCGCCGACGGCTTCTATCTGCCGACGCACACCGGACTGACCGCACAGGAGCAGGAGTTC
ATCACCGGCCGGATCCGCGCGTTCTACGGAGTGGCATGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase (Family) PIRSF000390 PLP_StrS PF01041 DegT_DnrJ_EryC1 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (Domain) G3DSA:3.40.640.10 PyrdxlP-dep_Trfase_major_sub1 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (Domain) G3DSA:3.90.1150.10 PyrdxlP-dep_Trfase_major_sub2 IPR015424 Pyridoxal phosphate-dependent transferase, major domain (Domain) SSF53383 PyrdxlP-dep_Trfase_major
SignalP	No significant hit
TMHMM	No significant hit

Nysta_00100 Nysta_00120

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