close all open/close all

CDS information : Nysta_00170


close this sectionLocation

Organism
StrainATCC 11455 (=NBRC 15452)
Entry nameNystatin
Contig
Start / Stop / Direction111,258 / 114,158 / + [in whole cluster]
111,258 / 114,158 / + [in contig]
Location111258..114158 [in whole cluster]
111258..114158 [in contig]
TypeCDS
Length2,901 bp (966 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
ProductLuxR family transcriptional regulator
Product (GenBank)NysRI
Gene
Gene (GenBank)nysRI
EC number
Keyword
Note
Note (GenBank)
  • transcriptional regulator
Reference
ACC
PmId
[10873841] Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. (Chem Biol. , 2000)
[14973031] In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. (J Bacteriol. , 2004)

close this sectionSequence

selected fasta
>LuxR family transcriptional regulator [NysRI]
MRKQSGSSGLLTTLVGRDDELRTLARHAAAARDGRAGLVLLHGPAGMGKTSLLRSFTASD
VCRGMTVLYGTCGETVAGAGYGGVRELLGGLGLSGGDARRSPLLEGLAARALPALTADPA
GPDAATGAYPVLHGLYWLAARLMAQRPLVLVLDDVHWCDERSLAWIDFLLRRAEDLPLLV
VLAWRSEAEPVAPAVLADIAAQRRPTVLGLHPLGPDDIGEMVRRVFRTTAAPSFVSRVAA
VSGGNPLALARLLDELRAEGVRPDAAGERRAAEVGSHVLARSVRCLLERRPPWVRGVARA
IAVLGPECTELLAALAGVPAATVDEALLVLRRAGILAADRVDFVHDVVRSAVLDDVAPPT
LAELRTNAALLLSDAGRPSEELAGQLMLLPVLDQPWMAAVLRDAAAQAESRGAPEAGVRC
LYRVLEVEPDNVAVRIQMARALAEINPPEAMRLLKEALSLAGDVRTRAQVAVQYGFTCLA
VQESPSGVRMLEDALAELTAELGPEPGPVDRELRTLVESVLLIVGADEKVTIGAVRDRAA
RLTMPPGDTPAQRQMLAMTTVLTAMDGRDARSAVDQARRALRAPGVELEPWSLLSASFAL
SLADEVADAQYALDLMLQYGQDNAAVWTYVLALSTRALLHHGVGAFPEALADAQTAVEIL
GEERWADGAVLPRVALATALVDRGEPERAEHVLDGITRPRLERFVIEYHWYLQARAYARW
VRGDFQGALDLLLACGRSLEESRFSNPAFVPWWADGAVLLATLDRHDQARELAAYGSELA
ERWGTARGLGLAFMAQGVAAPGRAGIDHLTEAVSLLADSPARAMEARAELLLGHAHLKRD
DLRAAREHLRAAADLAQRCGAVKLGVDARKLLVTAGGRVRRMTASPLDMLTGMERTVADL
AVTGASNRAIAEALFVTVRTIETHLTSVYRKLGVGGRAELSAVLETRTATSGRQPPAWVS
QARGRA
selected fasta
>LuxR family transcriptional regulator [NysRI]
ATGCGGAAGCAGTCGGGTTCTTCCGGCTTACTGACCACGCTGGTGGGACGCGACGACGAA
CTGCGCACCCTCGCCCGGCACGCCGCGGCCGCCCGCGACGGGCGGGCCGGCCTGGTCCTG
CTCCACGGGCCCGCCGGCATGGGCAAGACCAGTCTGCTGCGGTCCTTCACGGCGAGCGAT
GTCTGCCGCGGCATGACGGTGCTGTACGGCACCTGCGGCGAGACCGTCGCCGGCGCCGGG
TACGGCGGTGTGCGCGAACTCCTCGGCGGGCTCGGCCTGAGCGGCGGCGACGCCCGGCGC
TCGCCCCTCCTGGAGGGCCTGGCGGCCCGCGCGCTGCCCGCACTCACCGCAGACCCCGCC
GGTCCCGACGCCGCCACGGGTGCCTACCCGGTGCTGCACGGCCTGTACTGGCTCGCCGCC
CGCCTCATGGCCCAACGGCCGCTGGTCCTCGTCCTCGACGACGTCCACTGGTGCGACGAA
CGCTCCCTGGCCTGGATCGACTTCCTGCTGCGACGCGCCGAGGACCTGCCGCTGCTGGTC
GTCCTGGCCTGGCGCAGCGAGGCCGAACCGGTCGCGCCCGCGGTGCTCGCCGACATCGCC
GCCCAGCGCCGCCCCACCGTGCTCGGCCTGCACCCGCTCGGCCCCGACGACATAGGCGAA
ATGGTGCGTCGCGTCTTCCGGACCACGGCCGCACCGTCGTTCGTCAGCCGGGTCGCCGCC
GTGTCCGGCGGCAATCCGCTGGCCCTCGCCCGCCTCCTCGACGAACTCCGCGCCGAGGGC
GTCCGGCCGGACGCCGCCGGGGAGCGCCGGGCCGCCGAGGTCGGCAGTCACGTCCTCGCC
CGCTCGGTGCGCTGCCTGTTGGAGCGCCGGCCGCCCTGGGTGCGCGGCGTGGCCCGTGCC
ATCGCCGTACTCGGCCCGGAGTGCACCGAGTTGCTGGCGGCGCTCGCCGGCGTCCCGGCC
GCGACCGTCGACGAGGCCCTGTTGGTGCTGCGCAGGGCCGGCATCCTGGCCGCCGACCGC
GTGGACTTCGTCCATGACGTCGTCCGCTCCGCGGTGCTCGACGACGTCGCCCCGCCCACC
CTGGCCGAACTGCGCACCAACGCCGCGCTGTTGCTGAGCGACGCCGGCCGCCCCTCCGAG
GAGCTCGCCGGCCAGCTCATGCTGCTGCCGGTGCTCGACCAGCCGTGGATGGCCGCGGTG
CTGCGCGACGCCGCCGCCCAGGCGGAGAGCCGCGGCGCCCCGGAGGCCGGTGTGCGCTGC
CTCTACCGGGTGTTGGAGGTGGAGCCGGACAACGTTGCCGTCCGCATCCAGATGGCCCGC
GCGCTCGCCGAGATCAACCCGCCCGAGGCGATGCGCCTCCTCAAGGAAGCGCTCTCCCTC
GCCGGGGACGTCCGCACCCGCGCCCAGGTCGCCGTCCAGTACGGCTTCACCTGCCTCGCC
GTGCAGGAATCCCCGTCCGGGGTGCGGATGCTGGAGGACGCGCTCGCCGAGCTGACCGCC
GAACTGGGCCCCGAACCAGGGCCCGTGGACCGGGAGTTGCGGACCCTCGTGGAGTCCGTG
CTGCTCATCGTCGGGGCCGACGAGAAGGTGACGATCGGTGCGGTCCGCGACCGGGCGGCC
CGGCTCACCATGCCGCCCGGCGACACACCGGCCCAGCGGCAGATGCTGGCCATGACCACC
GTGCTGACCGCGATGGACGGCCGGGACGCCCGGTCGGCCGTCGACCAGGCCCGCCGCGCC
CTGCGCGCACCCGGCGTCGAGCTGGAACCCTGGTCGCTGCTGTCCGCCTCCTTCGCCCTC
TCCCTGGCCGACGAGGTCGCCGACGCGCAGTACGCACTGGACCTCATGCTCCAGTACGGC
CAGGACAACGCGGCGGTGTGGACGTACGTCCTGGCGCTCTCCACGCGCGCCCTGCTCCAC
CACGGGGTGGGCGCCTTCCCCGAGGCCCTGGCCGACGCCCAGACCGCCGTCGAGATCCTC
GGCGAGGAGCGCTGGGCGGACGGCGCCGTGCTGCCCCGTGTCGCGCTGGCCACCGCCCTC
GTCGACCGCGGCGAGCCCGAGCGCGCCGAACACGTCCTCGACGGCATCACCCGCCCCCGC
CTCGAACGCTTCGTCATCGAATACCACTGGTACCTCCAGGCCCGCGCCTACGCCCGCTGG
GTCCGCGGGGATTTCCAAGGAGCCCTGGACCTCCTTCTCGCCTGCGGTCGGTCCCTGGAG
GAGTCGCGCTTCAGCAACCCGGCGTTCGTGCCGTGGTGGGCCGATGGCGCGGTGCTCCTG
GCGACCCTGGACCGCCACGACCAGGCGCGCGAACTCGCCGCATACGGAAGCGAGTTGGCC
GAGCGTTGGGGGACGGCGCGCGGCCTCGGACTGGCCTTCATGGCCCAGGGCGTCGCCGCA
CCCGGCCGCGCCGGCATCGATCACCTCACCGAGGCGGTCTCGCTGCTCGCGGACTCCCCG
GCCCGGGCCATGGAGGCCCGGGCCGAACTTCTTCTCGGACACGCCCACCTGAAGCGCGAC
GACCTGCGGGCCGCCCGGGAACACCTGCGCGCCGCCGCCGACCTCGCCCAGCGCTGCGGC
GCCGTGAAGCTCGGCGTCGACGCCAGAAAACTGCTGGTCACCGCGGGTGGTCGGGTACGC
AGGATGACCGCCTCCCCACTCGACATGCTGACCGGGATGGAACGCACGGTGGCGGACCTC
GCGGTGACCGGCGCGAGCAACCGGGCCATCGCGGAAGCCCTCTTCGTGACTGTAAGGACC
ATCGAAACCCATCTCACGAGCGTCTACCGGAAGCTCGGGGTCGGCGGGCGTGCGGAGCTG
TCCGCCGTCCTGGAGACCAGGACCGCCACCTCCGGTCGGCAGCCGCCGGCCTGGGTCTCC
CAGGCACGCGGACGCGCTTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [888-942]  9.10000000000001e-13 PF00196
PF00196   GerE
 [890-904]  3.49999851148921e-07 PR00038 [904-920]  3.49999851148921e-07 PR00038 [920-932]  3.49999851148921e-07 PR00038
PR00038   HTHLUXR
 [887-944]  3.80000697093586e-20 SM00421
SM00421   HTH_LUXR
 [904-931]  PS00622
PS00622   HTH_LUXR_1
 [883-948]  PS50043
PS50043   HTH_LUXR_2
IPR011990 Tetratricopeptide-like helical (Domain)
 [393-493]  1.2e-12 G3DSA:1.25.40.10 [553-790]  1.5e-20 G3DSA:1.25.40.10 [827-897]  1.5e-20 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [898-944]  4.5e-17 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [868-954]  1.09999909120787e-14 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
IPR019734 Tetratricopeptide repeat (Repeat)
 [398-431]  0.259999982402629 SM00028 [630-663]  0.0909999926074527 SM00028 [826-859]  0.0140000007335441 SM00028
SM00028   TPR
SignalP
 [1-30]  0.247 Signal
Bacteria, Gram-positive   
TMHMM No significant hit