close all open/close all

CDS information : Nysta_00180


close this sectionLocation

Organism
StrainATCC 11455 (=NBRC 15452)
Entry nameNystatin
Contig
Start / Stop / Direction114,182 / 117,043 / + [in whole cluster]
114,182 / 117,043 / + [in contig]
Location114182..117043 [in whole cluster]
114182..117043 [in contig]
TypeCDS
Length2,862 bp (953 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
ProductLuxR family transcriptional regulator
Product (GenBank)NysRII
Gene
Gene (GenBank)nysRII
EC number
Keyword
Note
Note (GenBank)
  • putative transcriptional regulator
Reference
ACC
PmId
[10873841] Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. (Chem Biol. , 2000)
[14973031] In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. (J Bacteriol. , 2004)

close this sectionSequence

selected fasta
>LuxR family transcriptional regulator [NysRII]
MPRSKARNQPTTCTPQCAPDAHGDPTMLLECGREQRLIGDLLHRLGQGRPSVLSLTGRPG
HAQNALVRWGACRARHDGLRVLRAQATPAERELRYGAVLQLLAVLDGPHGSTLDAAIRHD
GPPPLPVPGIEEVLRRTGTAPTLVVVEDVQWLDPASLTWLQILLRHLGPDTPLAVLASSC
GDTTAFDTDPKAPAVPGPPDTVPVARFVVPALTDRGVAATVRAVCGTPGDEEFIAALTSA
TAGNPAILRDALRAFVDHGLPADADHLPELHALTAGVVGDHTVRALDGLPAEVNAVLRAL
AVCGDLLDFHRVRALAGAHSLSEDRIRTLLASVGLTVSVGDKVHIRFPASKARVIEDMPA
AERADLYVRAAELTHSCGVNDEDVAHLLLRSSPLGAPWVVPLLRRGFAAALRREDHHRAC
ACLSRALQEPLDPRERSLLTLELAAAEAVARPEAGDRRLGELVRSTVADTDPTSSGEGVG
VRAIDLGFARGNSEWVRRTAGEALPYAGPADREELVALFWLAAVRDDDAPMIPVVPRLPD
RPVPPAQAGARAWQLATAGEDADKARKLARIALTGGVNESLMMPKLAACAALFATDDNDE
AVHGLDTMLTAARSAHLRSMAARIFNLRARIHLCAARLEAAERDLDSAERALPPTSWHPR
ALPNLIATRILVSMETGRPDRARRLAEAPVPAGGEEGVWWPALLLARARVAADDGDWEEA
LRLSRECGRWLFRRHWANPAMLSWRPLAAEACLKLGDVTEARRLRDEELFFADRWGTASA
RGIARLTTRRLFDDDGDRAVRRIREAAALLRDSPARLAYLWSRLSQAGAETAHGDTAAAA
RSWQAVARMTAAHPASRLATAARTLTVPSVPVATAPPTAVVPPGWRDLSEAEKDTVLLAA
RGHGNRQIAEQLAVSRRTVELRLSNAYRKLRIGGRKELYLLLEALEGPVADAS
selected fasta
>LuxR family transcriptional regulator [NysRII]
GTGCCCCGGAGCAAGGCGCGGAACCAACCGACCACCTGCACGCCGCAGTGCGCACCCGAC
GCCCACGGCGACCCCACCATGCTCCTCGAATGCGGCCGGGAACAGCGGCTCATCGGCGAC
CTCCTGCACCGCCTCGGCCAGGGGCGGCCATCGGTGCTCAGCCTGACCGGCCGGCCCGGG
CACGCCCAGAACGCCCTGGTCCGCTGGGGCGCGTGCCGGGCCAGGCACGACGGGCTGCGC
GTCCTGCGAGCCCAGGCGACGCCCGCGGAACGGGAACTCCGCTACGGCGCCGTTCTCCAA
CTGCTGGCCGTCCTCGACGGCCCGCACGGCAGCACCCTGGACGCCGCGATCCGCCACGAC
GGTCCCCCGCCACTGCCCGTGCCCGGCATCGAGGAGGTGCTGCGGCGCACCGGCACGGCA
CCCACCCTGGTCGTGGTCGAAGACGTCCAGTGGTTGGACCCGGCCTCGCTGACGTGGTTG
CAGATCCTGCTGCGCCACCTCGGGCCGGACACCCCGCTCGCCGTCCTGGCCAGCAGCTGC
GGTGACACCACGGCCTTCGACACCGACCCGAAGGCCCCCGCCGTCCCGGGGCCGCCGGAC
ACCGTGCCCGTCGCGCGCTTCGTGGTGCCCGCGCTCACCGACCGCGGGGTCGCCGCCACC
GTCCGCGCCGTCTGCGGCACCCCCGGCGACGAGGAGTTCATCGCCGCGCTCACCTCCGCC
ACCGCCGGCAACCCCGCCATCCTGCGGGACGCCCTGCGCGCCTTCGTCGACCACGGCCTC
CCCGCCGACGCCGACCACCTCCCGGAGCTGCACGCCCTCACCGCTGGCGTCGTCGGCGAC
CACACCGTGCGCGCCCTGGACGGCCTGCCCGCCGAAGTCAACGCCGTCCTGCGGGCCCTG
GCCGTCTGCGGCGACCTGCTCGACTTCCACCGAGTCCGGGCCCTCGCCGGCGCGCACTCG
CTGTCCGAGGACCGGATCCGCACCCTGCTGGCGAGCGTCGGCCTGACCGTGTCCGTCGGC
GACAAGGTGCACATCCGCTTCCCCGCCTCCAAGGCACGCGTCATCGAGGACATGCCCGCC
GCGGAGCGCGCCGATCTGTACGTCCGCGCGGCCGAACTCACCCACAGTTGCGGCGTCAAC
GACGAGGACGTCGCCCATCTGCTGCTGCGCTCGTCGCCGCTCGGCGCACCCTGGGTCGTG
CCCCTGCTCCGCCGCGGATTCGCCGCCGCGCTGCGCCGGGAGGACCACCACCGGGCCTGT
GCCTGCCTCTCCCGCGCCCTGCAGGAACCCCTCGACCCCCGGGAACGCAGCCTGCTGACG
TTGGAACTGGCCGCGGCCGAAGCCGTCGCCCGGCCGGAGGCGGGGGATCGACGCCTGGGG
GAACTCGTCCGCAGCACCGTCGCGGACACCGACCCCACGTCGTCCGGTGAGGGGGTGGGG
GTCCGCGCCATCGACCTGGGGTTCGCCCGGGGCAACAGCGAATGGGTCCGCCGCACCGCG
GGCGAGGCCCTGCCGTACGCCGGGCCGGCCGACCGGGAGGAACTGGTCGCGCTGTTCTGG
TTGGCCGCCGTGCGGGACGACGACGCGCCGATGATCCCCGTGGTGCCCCGGTTGCCCGAC
CGGCCGGTGCCGCCGGCCCAGGCCGGCGCCCGTGCCTGGCAGCTGGCCACGGCGGGGGAG
GACGCGGACAAGGCCAGGAAGCTCGCCCGGATCGCCCTCACCGGCGGGGTGAACGAGAGC
CTGATGATGCCGAAACTGGCGGCCTGCGCCGCGCTGTTCGCCACCGACGACAACGACGAG
GCGGTGCACGGCCTGGACACCATGCTCACCGCCGCCCGCAGTGCCCACCTGCGCAGCATG
GCCGCCCGCATTTTCAACCTACGGGCCCGGATACACCTGTGCGCGGCCCGGCTGGAGGCC
GCCGAACGCGATCTGGACAGCGCCGAGCGCGCCCTGCCGCCGACGAGTTGGCACCCCCGT
GCGCTGCCCAACCTGATCGCCACCCGCATCCTCGTCAGCATGGAGACGGGCCGCCCGGAC
CGGGCCCGCCGACTCGCCGAGGCCCCGGTCCCCGCCGGCGGCGAGGAGGGTGTGTGGTGG
CCCGCCCTGCTGCTCGCCCGCGCCCGTGTGGCCGCCGACGACGGTGACTGGGAGGAGGCC
CTGCGGCTGTCGCGGGAGTGCGGGCGCTGGCTTTTTCGCCGGCACTGGGCCAACCCGGCC
ATGCTCAGTTGGCGCCCGCTGGCCGCCGAGGCGTGTCTGAAGCTCGGCGACGTGACGGAG
GCGCGCCGGCTGCGGGACGAGGAGCTGTTCTTCGCCGACCGCTGGGGCACCGCGAGCGCC
CGCGGGATCGCCCGCCTGACGACGCGGCGACTCTTCGACGACGACGGCGACCGGGCCGTC
CGGCGGATCCGCGAGGCCGCCGCCCTGCTCCGCGACTCGCCCGCCCGCCTGGCCTACCTG
TGGAGCCGGCTGAGCCAGGCCGGTGCCGAGACGGCCCACGGCGACACCGCCGCGGCCGCA
CGCTCCTGGCAGGCGGTCGCCCGGATGACCGCCGCCCACCCCGCCAGCCGCCTCGCCACC
GCCGCCCGCACCCTGACCGTCCCGTCCGTTCCGGTCGCCACCGCGCCGCCCACCGCCGTC
GTCCCACCCGGATGGCGCGACCTGTCCGAGGCGGAGAAGGACACCGTGCTGCTCGCCGCC
CGCGGCCACGGCAACCGCCAGATCGCCGAACAACTCGCCGTCAGCAGGCGCACCGTGGAG
CTCCGGCTGAGCAACGCCTACCGCAAGCTGAGGATCGGCGGACGCAAGGAGCTGTACCTG
CTCCTGGAGGCGCTGGAAGGACCGGTCGCGGATGCTTCTTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [881-946]  PS50043
PS50043   HTH_LUXR_2
 [902-929]  PS00622
PS00622   HTH_LUXR_1
 [888-902]  7.60000011115813e-07 PR00038 [902-918]  7.60000011115813e-07 PR00038 [918-930]  7.60000011115813e-07 PR00038
PR00038   HTHLUXR
 [885-942]  7.30000590915208e-14 SM00421
SM00421   HTH_LUXR
 [887-941]  3.8e-10 PF00196
PF00196   GerE
IPR011990 Tetratricopeptide-like helical (Domain)
 [554-826]  9.40000000000003e-15 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [883-942]  1.6e-13 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [866-945]  1.29999924468179e-14 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP
 [1-23]  0.213 Signal
Bacteria, Gram-negative   
 [1-6]  0.099 Signal
Eukaryota   
TMHMM No significant hit