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CDS information : Rubra_00460

Location

Organism	Streptomyces achromogenes var. rubradiris
Strain	NRRL3061 (=NBRC 14000)
Entry name	Rubradirin
Contig	AJ871581
Start / Stop / Direction	86,106 / 87,158 / + [in whole cluster] 86,106 / 87,158 / + [in contig]
Location	86106..87158 [in whole cluster] 86106..87158 [in contig]
Type	CDS
Length	1,053 bp (350 aa)

Annotation

Category	2.2 modification addition of starter unit
Product	putative aminodehydroquinate synthase
Product (GenBank)	putative aDHQ synthase
Gene
Gene (GenBank)	rubG
EC number	4.2.3.-
Keyword	AHBA
Note
Note (GenBank)
Reference	ACC Q2PC44 PmId [18080113] Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061. (Arch Microbiol. , 2008)
Related Reference	ACC O52549 NITE Rifam_00280 PmId [11278540] Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. (J Biol Chem. , 2001)
Related Reference	ACC P0A4Z4 PmId [17586643] Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification. (J Bacteriol. , 2007) [1910148] The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. (Mol Gen Genet. , 1991)

Sequence

>putative aminodehydroquinate synthase [putative aDHQ synthase]
MTAVSLRLRDQSYEVIIGPGVRTALAGVVRRLGAQRAVVVSARPRPWVPDTGVPSLVLPA
LDGEQGKTLGTVESLCGEFARFGLTRSDVVVSCGGGTTTDVVGLAAALYHRGVPVVHLPT
SLLAQVDAGVGGKTAVNLPAGKNLVGTYWQPSAVLCDTDYLSTLPRREMLSGLGEIARCH
FIGAPDLRGLPLAEQITASVRLKARIVEADERDTGMRHLLNYGHTLGHAVERATGYAVRH
GEAVAIGTVFAGRLAGALGRIGQARVAEHHDVVRHYGLPAALPAEAGTAALMRLMRQDKK
AVRGLTFVLDGPKGAELVSDVPPDVVAGVLEGMPRTCMADLVASSGGAGR

>putative aminodehydroquinate synthase [putative aDHQ synthase]
ATGACCGCGGTTTCTCTGCGTCTGAGAGATCAGTCGTATGAGGTGATCATTGGTCCGGGG
GTGCGGACGGCGCTCGCCGGCGTCGTCCGGCGGCTGGGCGCCCAGCGAGCGGTCGTCGTG
TCGGCTCGCCCACGGCCATGGGTGCCCGACACCGGGGTGCCCAGCCTGGTGCTGCCCGCG
CTCGACGGCGAGCAGGGCAAGACCCTCGGTACGGTGGAGTCGTTGTGCGGTGAGTTCGCA
CGGTTCGGGCTGACCAGGTCCGACGTGGTGGTCTCGTGCGGCGGCGGTACCACCACGGAT
GTCGTCGGGCTGGCGGCCGCGCTGTACCACCGGGGCGTGCCGGTGGTTCATCTGCCGACC
TCCCTGCTGGCCCAGGTGGATGCCGGCGTCGGCGGGAAGACGGCGGTGAACCTGCCCGCC
GGCAAGAACCTGGTCGGCACGTACTGGCAGCCCAGCGCGGTGCTCTGCGACACTGACTAC
CTGTCGACCCTGCCGCGGCGGGAGATGCTCAGTGGCCTCGGCGAAATCGCCCGCTGCCAC
TTCATCGGGGCGCCGGACCTGCGGGGGCTGCCCCTGGCCGAGCAGATCACGGCCAGCGTG
CGGCTCAAGGCCCGCATCGTGGAGGCGGACGAGCGGGACACCGGGATGCGGCACCTGCTC
AACTACGGCCACACGCTGGGCCATGCGGTGGAGAGAGCGACGGGCTACGCGGTGCGGCAC
GGCGAGGCGGTGGCCATCGGAACGGTCTTCGCGGGACGGCTCGCCGGTGCTCTGGGCCGT
ATCGGGCAGGCCCGGGTGGCAGAGCATCACGACGTCGTCCGGCATTACGGGCTTCCCGCC
GCACTGCCGGCCGAGGCCGGCACCGCCGCCCTGATGCGGTTGATGCGGCAGGACAAGAAG
GCGGTCCGGGGACTCACCTTCGTCCTGGACGGCCCCAAGGGCGCGGAGCTGGTGAGCGAC
GTCCCGCCGGATGTGGTCGCGGGGGTGCTGGAGGGGATGCCGCGCACGTGCATGGCCGAC
CTCGTCGCTTCGTCGGGTGGGGCTGGTCGATGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR002658 3-dehydroquinate synthase AroB (Domain) PF01761 DHQ_synthase IPR016303 3-dehydroquinate synthase (Family) PIRSF001455 DHQ_synth
SignalP	Bacteria, Gram-negative Eukaryota
TMHMM	No significant hit

Rubra_00450 Rubra_00470

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