Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | LAR_0245 |
|---|
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| 必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | LAR_0694 |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | LAR_1450 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | LAR_1452 |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | LAR_0328 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | LAR_1450 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | LAR_1450 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | LAR_1457 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | LAR_1457 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | LAR_1013 |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | LAR_1208 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | LAR_1213 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | LAR_1212 |
FOLC (NRULE_0160) | Bifunctional protein FolC | LAR_1210 LAR_0496 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | |
DHPS (NRULE_0144) | Dihydropteroate synthase | LAR_1208 |
FOLA (NRULE_0147) | Dihydrofolate reductase | LAR_0740 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | LAR_1213 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | LAR_1212 |
FOLC (NRULE_0160) | Bifunctional protein FolC | LAR_0496 LAR_1210 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | |
DHPS (NRULE_0144) | Dihydropteroate synthase | LAR_1208 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | LAR_1213 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | LAR_1212 |
FOLC (NRULE_0160) | Bifunctional protein FolC | LAR_0496 LAR_1210 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
Histamine biosynthesis(NFUNC_0078) |
| 必須 | A | HDCA (NRULE_0244) | Histidine decarboxylase proenzyme | LAR_1717 |
|---|
| B | HDC (NRULE_0245) | Histidine decarboxylase | |
| 任意 | | HDCP (NRULE_0246) | Histidine/histamine antiporter | LAR_1718 |
|---|
| | HDCB (NRULE_0247) | HdcB protein | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | LAR_0328 |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | LAR_0563 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Malolactic fermentation(NFUNC_0070) |
| 必須 | A | MLE (NRULE_0233) | Malolactic enzyme | LAR_1441 |
|---|
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | LAR_0338 LAR_1750 |
PANC (NRULE_0118) | Pantothenate synthetase | |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | LAR_1450 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | LAR_0826 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | LAR_0826 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | LAR_0827 |
RIBE (NRULE_0204) | Riboflavin synthase | LAR_0825 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | LAR_0675 |
|---|
Streptomycin resistance(NFUNC_0054) |
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | LAR_0694 |
| 任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | LAR_1480 |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | LAR_1480 |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Trehalose biosynthesis (from maltose)(NFUNC_0034) |
| 必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase | LAR_0052 |
|---|
TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase | |
| B | TRES (NRULE_0128) | Trehalose synthase | |
