Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | Lferr_2441 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_0428 Lferr_1354 Lferr_0984 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2707 Lferr_2351 Lferr_0858 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| 必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | Lferr_2642 |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_1354 Lferr_0428 Lferr_0984 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2707 Lferr_2351 Lferr_0858 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Lferr_2845 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | Lferr_2846 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_0984 Lferr_0428 Lferr_1354 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2707 Lferr_0858 Lferr_2351 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_0984 Lferr_0428 Lferr_1354 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_0858 Lferr_2707 Lferr_2351 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | Lferr_2479 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | Lferr_2479 |
ARSC2 (NRULE_0018) | Arsenate reductase | Lferr_2481 |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | Lferr_2479 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | Lferr_2481 |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | Lferr_2478 |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | Lferr_0787 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_0984 Lferr_0428 Lferr_1354 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_0858 Lferr_2707 Lferr_2351 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | Lferr_0419 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | Lferr_0422 Lferr_1373 |
BIOB (NRULE_0185) | Biotin synthase | Lferr_0436 |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | Lferr_1865 Lferr_1742 Lferr_1073 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | Lferr_1073 Lferr_1742 Lferr_1865 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Lferr_2845 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | Lferr_2261 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Lferr_0126 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Lferr_1449 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Lferr_1724 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Lferr_0730 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | Lferr_1586 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | Lferr_2845 |
DHPS (NRULE_0144) | Dihydropteroate synthase | Lferr_2261 |
FOLA (NRULE_0147) | Dihydrofolate reductase | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Lferr_0126 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Lferr_1449 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Lferr_1724 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Lferr_0730 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | Lferr_1586 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | Lferr_2845 |
DHPS (NRULE_0144) | Dihydropteroate synthase | Lferr_2261 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Lferr_0126 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Lferr_1449 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Lferr_1724 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Lferr_0730 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | Lferr_1586 |
Mercury resistance(NFUNC_0005) |
| 必須 | A | MERA (NRULE_0008) | Mercuric reductase | Lferr_2107 |
|---|
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | Lferr_1261 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Lferr_1211 Lferr_0050 Lferr_0044 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Lferr_1211 Lferr_0050 Lferr_0044 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | Lferr_2592 Lferr_2890 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_0984 Lferr_1354 Lferr_0428 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2351 Lferr_0858 Lferr_2707 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrogenase(NFUNC_0094) |
| 必須 | A | NIFD (NRULE_0347) | Nitrogenase molybdenum-iron protein alpha chain | Lferr_1239 |
|---|
NIFK (NRULE_0348) | Nitrogenase molybdenum-iron protein beta chain | Lferr_1238 |
VNFH (NRULE_0353) | Nitrogenase reductase | Lferr_1240 |
| B | ANFD (NRULE_0344) | Nitrogenase iron-iron protein alpha chain | |
ANFK (NRULE_0345) | Nitrogenase iron-iron protein beta chain | |
ANFG (NRULE_0346) | Nitrogenase iron-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | Lferr_1240 |
| C | VNFD (NRULE_0349) | Nitrogenase vanadium-iron protein alpha chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFG (NRULE_0352) | Nitrogenase vanadium-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | Lferr_1240 |
| D | VNFK (NRULE_0350) | Nitrogenase vanadium-iron protein alpha/delta chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | Lferr_1240 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | Lferr_2688 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | Lferr_1447 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | |
PANC (NRULE_0118) | Pantothenate synthetase | Lferr_1446 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_1354 Lferr_0984 Lferr_0428 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2707 Lferr_0858 Lferr_2351 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | Lferr_0475 Lferr_1663 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | Lferr_0475 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | Lferr_0473 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | Lferr_0476 |
RIBE (NRULE_0204) | Riboflavin synthase | Lferr_0474 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | Lferr_0712 |
|---|
Streptomycin resistance(NFUNC_0054) |
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | Lferr_2642 |
| 任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | Lferr_1354 Lferr_0984 Lferr_0428 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Lferr_2707 Lferr_0858 Lferr_2351 |
Trehalose biosynthesis (from D-glucose and ADP-glucose)(NFUNC_0032) |
| 必須 | A | TRET (NRULE_0121) | Trehalose synthase | Lferr_1740 |
|---|
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | Lferr_1738 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | Lferr_1739 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | |
|---|
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | Lferr_1017 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | Lferr_0344 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | Lferr_1124 |
