Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | AZC_4216 AZC_2065 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1372 AZC_1174 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | AZC_0605 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_1173 AZC_3662 AZC_3501 AZC_3427 AZC_3406 |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AZC_4278 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1174 AZC_1372 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3406 AZC_3662 AZC_3501 AZC_3427 AZC_1173 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | AZC_2207 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | AZC_2208 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1174 AZC_1372 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3406 AZC_3501 AZC_3662 AZC_1173 AZC_3427 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | AZC_1287 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | AZC_1173 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1174 AZC_1372 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3427 AZC_3501 AZC_3662 AZC_3406 AZC_1173 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | AZC_1272 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | AZC_1271 AZC_4550 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | AZC_1272 |
ARSC2 (NRULE_0018) | Arsenate reductase | AZC_1270 |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | AZC_1272 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | AZC_4550 AZC_1271 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | AZC_1270 |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | AZC_1274 |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | AZC_0163 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | AZC_4674 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1372 AZC_1174 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3427 AZC_3662 AZC_3501 AZC_1173 AZC_3406 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AZC_4278 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | AZC_1183 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | AZC_1184 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Bioplastic degradation(NFUNC_0015) |
| 必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | AZC_0295 AZC_4691 |
|---|
| B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | |
| C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
| 任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
|---|
Bioplastic synthesis(NFUNC_0001) |
| 必須 | A | PHAC1 (NRULE_0010) | Poly(3-hydroxyalkanoate) polymerase | AZC_1845 |
|---|
| B | PHAE (NRULE_0012) | Poly(3-hydroxyalkanoate) polymerase PhaE subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
| C | PHAR (NRULE_0013) | Poly(3-hydroxyalkanoate) polymerase PhaR subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
| 任意 | | PHAB (NRULE_0011) | Acetoacetyl-CoA reductase | AZC_0305 |
|---|
| | PHAP1 (NRULE_0374) | Phasin | AZC_2250 |
| | PHAP2 (NRULE_0375) | Phasin | |
| | PHAP3 (NRULE_0376) | Phasin | |
| | PHAF (NRULE_0377) | Phasin PhaF | |
| | PHAI (NRULE_0378) | Phasin PhaI | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | |
BIOB (NRULE_0185) | Biotin synthase | AZC_0361 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | AZC_2339 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | AZC_3458 AZC_2343 AZC_1444 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | AZC_2339 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | AZC_3458 AZC_2343 AZC_1444 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | AZC_2339 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | AZC_1444 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | AZC_2339 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | AZC_1444 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | AZC_4278 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | AZC_1648 AZC_3434 AZC_0988 AZC_0370 AZC_0688 AZC_0916 AZC_1881 |
CLCE (NRULE_0384) | Maleylacetate reductase | AZC_1411 |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | AZC_0988 AZC_0916 AZC_0688 AZC_0370 AZC_1648 AZC_3434 AZC_1881 |
CLCE (NRULE_0384) | Maleylacetate reductase | AZC_1411 |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_0716 AZC_4190 AZC_3159 AZC_2984 AZC_2489 |
|---|
1,3-dichloropropene degradation(NFUNC_0012) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
CAAD (NRULE_0076) | 3-chloroacrylic acid dehalogenase | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | AZC_3698 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
CAADA (NRULE_0077) | 3-chloroacrylic acid dehalogenase alpha subunit | |
CAADB (NRULE_0078) | 3-chloroacrylic acid dehalogenase beta subunit | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | AZC_3698 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | AZC_2207 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | AZC_1218 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AZC_1812 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AZC_1217 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AZC_1025 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | AZC_1598 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | AZC_2207 |
DHPS (NRULE_0144) | Dihydropteroate synthase | AZC_1218 |
FOLA (NRULE_0147) | Dihydrofolate reductase | AZC_4483 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AZC_1812 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AZC_1217 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AZC_1025 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | AZC_1598 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | AZC_2207 |
DHPS (NRULE_0144) | Dihydropteroate synthase | AZC_1218 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AZC_1812 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AZC_1217 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AZC_1025 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | AZC_1598 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | AZC_2705 AZC_2033 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | AZC_2387 |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | AZC_0163 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_4190 AZC_0716 AZC_2489 AZC_2984 AZC_3159 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_3159 AZC_2984 AZC_2489 AZC_0716 AZC_4190 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_3159 AZC_2984 AZC_2489 AZC_0716 AZC_4190 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_0716 AZC_2489 AZC_2984 AZC_3159 AZC_4190 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | AZC_1054 AZC_1791 AZC_2370 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | AZC_1791 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | AZC_2368 AZC_0922 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | AZC_2368 AZC_0922 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | AZC_1791 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | AZC_2369 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | AZC_2370 |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | AZC_0054 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | AZC_1173 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | AZC_1173 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1174 AZC_1372 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3406 AZC_3427 AZC_3501 AZC_3662 AZC_1173 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | AZC_3797 |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | AZC_3798 |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | AZC_3796 |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | AZC_3934 AZC_3800 AZC_1103 AZC_1001 AZC_0565 |
Nitrogenase(NFUNC_0094) |
| 必須 | A | NIFD (NRULE_0347) | Nitrogenase molybdenum-iron protein alpha chain | AZC_1040 |
|---|
NIFK (NRULE_0348) | Nitrogenase molybdenum-iron protein beta chain | AZC_1039 |
VNFH (NRULE_0353) | Nitrogenase reductase | AZC_3443 AZC_1041 |
| B | ANFD (NRULE_0344) | Nitrogenase iron-iron protein alpha chain | |
ANFK (NRULE_0345) | Nitrogenase iron-iron protein beta chain | |
ANFG (NRULE_0346) | Nitrogenase iron-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | AZC_1041 AZC_3443 |
| C | VNFD (NRULE_0349) | Nitrogenase vanadium-iron protein alpha chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFG (NRULE_0352) | Nitrogenase vanadium-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | AZC_1041 AZC_3443 |
| D | VNFK (NRULE_0350) | Nitrogenase vanadium-iron protein alpha/delta chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | AZC_1041 AZC_3443 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | AZC_4331 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | AZC_0464 |
PANC (NRULE_0118) | Pantothenate synthetase | AZC_1589 |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AZC_4278 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | AZC_4189 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1372 AZC_1174 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3662 AZC_3501 AZC_3427 AZC_3406 AZC_1173 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AZC_4190 AZC_0716 AZC_3159 AZC_2489 AZC_2984 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | AZC_1442 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | AZC_1443 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | AZC_1441 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | AZC_1444 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | AZC_3458 AZC_1444 AZC_2343 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | AZC_1442 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | AZC_1443 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | AZC_1441 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | AZC_1444 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AZC_0994 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AZC_0995 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AZC_0996 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | AZC_3102 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | AZC_3102 AZC_4172 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | AZC_1263 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | AZC_1265 |
RIBE (NRULE_0204) | Riboflavin synthase | AZC_1264 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | AZC_0098 |
|---|
Thiocyanate hydrolase(NFUNC_0003) |
| 必須 | A | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | AZC_3798 AZC_3796 |
|---|
SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | AZC_3798 AZC_3796 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| B | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | AZC_3798 AZC_3796 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| C | SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | AZC_3798 AZC_3796 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | AZC_1174 AZC_1372 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | AZC_1446 |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AZC_3406 AZC_1173 AZC_3662 AZC_3427 AZC_3501 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | AZC_1404 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | AZC_1403 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | AZC_2750 |
|---|
Trehalose biosynthesis (from maltose)(NFUNC_0034) |
| 必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase | |
|---|
TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase | |
| B | TRES (NRULE_0128) | Trehalose synthase | AZC_4115 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | AZC_0482 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | AZC_0483 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | AZC_4321 AZC_0175 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | AZC_2001 |
