Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | HMPREF0484_5583 HMPREF0484_2104 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1953 HMPREF0484_4135 HMPREF0484_1263 HMPREF0484_4396 HMPREF0484_3066 HMPREF0484_4609 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | HMPREF0484_4064 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_2756 HMPREF0484_4612 HMPREF0484_3754 HMPREF0484_2758 |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | HMPREF0484_4462 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_4135 HMPREF0484_3066 HMPREF0484_1953 HMPREF0484_1263 HMPREF0484_4396 HMPREF0484_4609 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_2756 HMPREF0484_3754 HMPREF0484_4612 HMPREF0484_2758 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0484_3175 HMPREF0484_5254 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | HMPREF0484_3174 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1953 HMPREF0484_1263 HMPREF0484_3066 HMPREF0484_4135 HMPREF0484_4396 HMPREF0484_4609 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_3754 HMPREF0484_2758 HMPREF0484_2756 HMPREF0484_4612 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | HMPREF0484_3056 HMPREF0484_4010 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | HMPREF0484_3754 HMPREF0484_4612 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | HMPREF0484_4610 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1263 HMPREF0484_4609 HMPREF0484_4396 HMPREF0484_4135 HMPREF0484_3066 HMPREF0484_1953 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_4612 HMPREF0484_3754 HMPREF0484_2758 HMPREF0484_2756 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0484_0207 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF0484_0206 HMPREF0484_2297 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0484_0207 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0484_0207 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF0484_2297 HMPREF0484_0206 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF0484_1416 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF0484_1415 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | HMPREF0484_2463 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | HMPREF0484_4608 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | HMPREF0484_4609 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1263 HMPREF0484_1953 HMPREF0484_3066 HMPREF0484_4135 HMPREF0484_4396 HMPREF0484_4609 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_3754 HMPREF0484_4612 HMPREF0484_2758 HMPREF0484_2756 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | HMPREF0484_4462 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | HMPREF0484_1573 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | HMPREF0484_1572 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | HMPREF0484_1379 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | HMPREF0484_1381 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | HMPREF0484_1377 HMPREF0484_4209 |
BIOB (NRULE_0185) | Biotin synthase | HMPREF0484_1380 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | HMPREF0484_4613 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_4170 HMPREF0484_3061 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | HMPREF0484_4613 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | HMPREF0484_4613 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | HMPREF0484_4613 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | HMPREF0484_4462 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chloramphenicol resistance(NFUNC_0025) |
| 必須 | A | CAT1 (NRULE_0107) | Chloramphenicol acetyltransferase | HMPREF0484_4739 |
|---|
| B | CAT4 (NRULE_0108) | Chloramphenicol acetyltransferase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | HMPREF0484_2431 HMPREF0484_2506 HMPREF0484_5427 HMPREF0484_2286 HMPREF0484_2315 HMPREF0484_1102 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | HMPREF0484_2315 HMPREF0484_2506 HMPREF0484_2286 HMPREF0484_5427 HMPREF0484_1102 HMPREF0484_2431 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_5100 HMPREF0484_1340 HMPREF0484_3733 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0484_0668 HMPREF0484_2474 HMPREF0484_4287 HMPREF0484_5091 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | HMPREF0484_4288 |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | HMPREF0484_4291 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | HMPREF0484_4290 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0484_4287 HMPREF0484_0668 HMPREF0484_5091 HMPREF0484_2474 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | HMPREF0484_4291 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | HMPREF0484_4290 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0484_5254 HMPREF0484_3175 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0484_2908 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | HMPREF0484_3011 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0484_3494 HMPREF0484_2462 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0484_4873 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0484_3507 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0484_2124 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0484_3359 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0484_5254 HMPREF0484_3175 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0484_2908 |
FOLA (NRULE_0147) | Dihydrofolate reductase | HMPREF0484_4981 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0484_2462 HMPREF0484_3494 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0484_4873 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0484_3507 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0484_2124 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0484_3359 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0484_5254 HMPREF0484_3175 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0484_2908 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0484_2462 HMPREF0484_3494 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0484_4873 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0484_3507 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0484_2124 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0484_3359 |
Fosfomycin resistance(NFUNC_0023) |
| 必須 | A | FOSA (NRULE_0098) | Glutathione transferase FosA | HMPREF0484_5126 |
|---|
| B | FOSB (NRULE_0099) | Metallothiol transferase FosB | |
| C | FOSX (NRULE_0100) | Fosfomycin resistance protein FosX | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF0484_1416 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF0484_1415 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0484_5100 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF0484_5091 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0484_5100 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_1340 HMPREF0484_3733 HMPREF0484_5100 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF0484_5091 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_3733 HMPREF0484_5100 HMPREF0484_1340 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_1340 HMPREF0484_5100 HMPREF0484_3733 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_5100 HMPREF0484_3733 HMPREF0484_1340 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF0484_5091 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0484_5100 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0484_5100 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF0484_5091 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF0484_5090 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF0484_5092 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF0484_5093 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF0484_5094 |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | HMPREF0484_2134 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | HMPREF0484_1258 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | HMPREF0484_1413 HMPREF0484_1409 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0484_1413 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0484_4279 HMPREF0484_1411 HMPREF0484_2247 HMPREF0484_5659 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | HMPREF0484_1829 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | HMPREF0484_5554 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | HMPREF0484_0812 |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | HMPREF0484_0537 |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0484_5659 HMPREF0484_2247 HMPREF0484_1411 HMPREF0484_4279 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0484_1413 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | HMPREF0484_1410 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | HMPREF0484_1409 |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | HMPREF0484_3754 HMPREF0484_4612 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | HMPREF0484_4610 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0484_2474 HMPREF0484_0668 HMPREF0484_4287 HMPREF0484_5091 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | HMPREF0484_4612 HMPREF0484_3754 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | HMPREF0484_4610 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0484_5091 HMPREF0484_0668 HMPREF0484_2474 HMPREF0484_4287 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1263 HMPREF0484_4135 HMPREF0484_1953 HMPREF0484_4609 HMPREF0484_4396 HMPREF0484_3066 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_2758 HMPREF0484_4612 HMPREF0484_3754 HMPREF0484_2756 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | HMPREF0484_0455 HMPREF0484_5156 HMPREF0484_5109 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | HMPREF0484_4876 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | HMPREF0484_4874 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | HMPREF0484_2627 |
PANC (NRULE_0118) | Pantothenate synthetase | HMPREF0484_4875 |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | HMPREF0484_4462 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_1953 HMPREF0484_4609 HMPREF0484_4396 HMPREF0484_4135 HMPREF0484_3066 HMPREF0484_1263 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_2758 HMPREF0484_2756 HMPREF0484_4612 HMPREF0484_3754 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0484_3733 HMPREF0484_5100 HMPREF0484_1340 |
Polymyxin resistance(NFUNC_0036) |
| 必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | HMPREF0484_0802 |
|---|
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | HMPREF0484_0803 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | HMPREF0484_0801 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | HMPREF0484_0799 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | HMPREF0484_0798 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | HMPREF0484_0800 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | HMPREF0484_4663 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | HMPREF0484_4662 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | HMPREF0484_4171 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | HMPREF0484_4173 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_3061 HMPREF0484_4170 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | HMPREF0484_4663 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | HMPREF0484_4662 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | HMPREF0484_4171 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | HMPREF0484_4169 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF0484_4170 HMPREF0484_3061 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
| 必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | HMPREF0484_4541 |
|---|
| 任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | |
|---|
| | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | HMPREF0484_4540 |
| | PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | HMPREF0484_4542 |
| | PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | HMPREF0484_4543 |
| | PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | HMPREF0484_4545 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | HMPREF0484_2472 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | HMPREF0484_3158 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | HMPREF0484_2615 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | HMPREF0484_2616 |
RIBE (NRULE_0204) | Riboflavin synthase | HMPREF0484_4720 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | HMPREF0484_4998 |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | HMPREF0484_4660 |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | HMPREF0484_4660 |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0484_3066 HMPREF0484_1263 HMPREF0484_1953 HMPREF0484_4135 HMPREF0484_4396 HMPREF0484_4609 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | HMPREF0484_5057 |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0484_4612 HMPREF0484_2756 HMPREF0484_2758 HMPREF0484_3754 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | HMPREF0484_0751 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | HMPREF0484_2194 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | HMPREF0484_2195 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | HMPREF0484_4029 |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | HMPREF0484_4028 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | HMPREF0484_4026 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | HMPREF0484_1570 HMPREF0484_3753 HMPREF0484_2405 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | HMPREF0484_5511 |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | HMPREF0484_3723 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | HMPREF0484_2741 |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | HMPREF0484_3513 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | HMPREF0484_1231 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | HMPREF0484_4977 HMPREF0484_3328 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | HMPREF0484_0567 |
