Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | ACT4_001_00810 ACT4_002_00150 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | ACT4_067_00170 |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | ACT4_038_01670 ACT4_036_00140 |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_021_03500 ACT4_038_00440 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | ACT4_013_00280 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | ACT4_013_00270 |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_052_00360 ACT4_036_00780 ACT4_052_00380 ACT4_038_00460 ACT4_040_00190 ACT4_047_00070 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_038_00440 ACT4_021_03500 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_052_00360 ACT4_052_00380 ACT4_040_00190 ACT4_036_00780 ACT4_038_00460 ACT4_047_00070 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | ACT4_034_00145 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | ACT4_014_01020 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_021_03500 ACT4_038_00440 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_040_00190 ACT4_052_00360 ACT4_047_00070 ACT4_038_00460 ACT4_036_00780 ACT4_052_00380 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | ACT4_013_00690 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | ACT4_038_00460 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | ACT4_038_00450 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_038_00440 ACT4_021_03500 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_036_00780 ACT4_038_00460 ACT4_040_00190 ACT4_047_00070 ACT4_052_00360 ACT4_052_00380 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | ACT4_006_00480 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | ACT4_006_00500 |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | ACT4_006_00510 |
ARSC1 (NRULE_0017) | Arsenate reductase | ACT4_006_00480 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | ACT4_006_00510 |
ARSC2 (NRULE_0018) | Arsenate reductase | ACT4_006_00500 |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | ACT4_006_00510 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | ACT4_006_00520 |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | ACT4_001_00610 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | ACT4_015_00080 ACT4_021_00220 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | ACT4_038_00460 |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | ACT4_038_00450 |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | ACT4_038_00430 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | ACT4_038_00440 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_021_03500 ACT4_038_00440 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_052_00380 ACT4_052_00360 ACT4_038_00460 ACT4_040_00190 ACT4_047_00070 ACT4_036_00780 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | ACT4_020_00170 |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | ACT4_021_00420 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | ACT4_021_00430 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | ACT4_021_01570 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | ACT4_021_01620 |
BIOB (NRULE_0185) | Biotin synthase | ACT4_028_01240 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | ACT4_038_00470 |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | ACT4_038_00490 |
CATC (NRULE_0054) | Muconolactone isomerase | ACT4_038_00480 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | ACT4_038_00380 ACT4_036_01070 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_038_00410 ACT4_036_01110 ACT4_064_00090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_064_00080 ACT4_036_01100 ACT4_038_00400 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_036_01090 ACT4_038_00390 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | ACT4_038_00470 |
CATC (NRULE_0054) | Muconolactone isomerase | ACT4_038_00480 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | ACT4_036_01070 ACT4_038_00380 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_038_00410 ACT4_064_00090 ACT4_036_01110 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_038_00400 ACT4_064_00080 ACT4_036_01100 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_038_00390 ACT4_036_01090 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | ACT4_038_00490 |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | ACT4_038_00470 |
CATC (NRULE_0054) | Muconolactone isomerase | ACT4_038_00480 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_038_00410 ACT4_064_00090 ACT4_036_01110 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_038_00400 ACT4_036_01100 ACT4_064_00080 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_038_00390 ACT4_036_01090 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | ACT4_038_00490 |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | ACT4_038_00470 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | ACT4_038_00490 |
CATC (NRULE_0054) | Muconolactone isomerase | ACT4_038_00480 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_038_00410 ACT4_064_00090 ACT4_036_01110 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_064_00080 ACT4_036_01100 ACT4_038_00400 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_038_00390 ACT4_036_01090 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | ACT4_020_00170 |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_036_01110 ACT4_064_00090 ACT4_038_00410 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_036_01100 ACT4_038_00400 ACT4_064_00080 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_036_01090 ACT4_038_00390 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | ACT4_052_00450 ACT4_038_00900 ACT4_021_00500 ACT4_020_00130 ACT4_017_00160 ACT4_006_00030 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | ACT4_038_00490 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_038_00410 ACT4_064_00090 ACT4_036_01110 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_064_00080 ACT4_038_00400 ACT4_036_01100 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_038_00390 ACT4_036_01090 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | ACT4_038_00900 ACT4_006_00030 ACT4_017_00160 ACT4_020_00130 ACT4_052_00450 ACT4_021_00500 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_004_00950 ACT4_038_00960 ACT4_025_01250 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | ACT4_045_00070 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | ACT4_045_00070 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | ACT4_023_00100 |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | ACT4_006_00920 |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | ACT4_006_00910 |
ECTC (NRULE_0188) | L-ectoine synthase | ACT4_006_00930 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | ACT4_034_00145 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | ACT4_037_00170 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | ACT4_025_01190 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | ACT4_006_01180 ACT4_025_01180 |
FOLC (NRULE_0160) | Bifunctional protein FolC | ACT4_031_00380 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | ACT4_005_00630 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | ACT4_034_00145 |
DHPS (NRULE_0144) | Dihydropteroate synthase | ACT4_037_00170 |
FOLA (NRULE_0147) | Dihydrofolate reductase | ACT4_004_00220 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | ACT4_025_01190 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | ACT4_025_01180 ACT4_006_01180 |
FOLC (NRULE_0160) | Bifunctional protein FolC | ACT4_031_00380 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | ACT4_005_00630 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | ACT4_034_00145 |
DHPS (NRULE_0144) | Dihydropteroate synthase | ACT4_037_00170 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | ACT4_025_01190 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | ACT4_006_01180 ACT4_025_01180 |
FOLC (NRULE_0160) | Bifunctional protein FolC | ACT4_031_00380 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | ACT4_005_00630 |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | ACT4_001_00610 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | ACT4_006_00940 |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | ACT4_006_00920 |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | ACT4_006_00910 |
| | ECTC (NRULE_0188) | L-ectoine synthase | ACT4_006_00930 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_025_01250 ACT4_038_00960 ACT4_004_00950 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_038_00960 ACT4_004_00950 ACT4_025_01250 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_025_01250 ACT4_004_00950 ACT4_038_00960 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_038_00960 ACT4_004_00950 ACT4_025_01250 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | ACT4_017_00080 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | ACT4_019_01490 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | ACT4_006_00350 |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | ACT4_023_01050 ACT4_007_00290 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | ACT4_010_00160 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | ACT4_006_00970 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | ACT4_023_01050 ACT4_007_00290 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | ACT4_023_01040 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | ACT4_023_01030 |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | ACT4_038_00460 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | ACT4_038_00450 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | ACT4_045_00070 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | ACT4_038_00460 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | ACT4_038_00450 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | ACT4_045_00070 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_021_03500 ACT4_038_00440 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_040_00190 ACT4_047_00070 ACT4_052_00380 ACT4_052_00360 ACT4_036_00780 ACT4_038_00460 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | ACT4_036_01320 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | ACT4_021_01990 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | ACT4_006_01190 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | |
PANC (NRULE_0118) | Pantothenate synthetase | ACT4_006_01200 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | ACT4_067_00160 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_038_00440 ACT4_021_03500 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_052_00380 ACT4_036_00780 ACT4_038_00460 ACT4_040_00190 ACT4_047_00070 ACT4_052_00360 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | ACT4_025_01250 ACT4_004_00950 ACT4_038_00960 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | ACT4_036_01030 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | ACT4_036_01040 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | ACT4_036_01080 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | ACT4_036_01050 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | ACT4_038_00380 ACT4_036_01070 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_036_01110 ACT4_038_00410 ACT4_064_00090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_064_00080 ACT4_036_01100 ACT4_038_00400 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_036_01090 ACT4_038_00390 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | ACT4_036_01030 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | ACT4_036_01040 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | ACT4_036_01080 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | ACT4_064_00090 ACT4_036_01110 ACT4_038_00410 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | ACT4_036_01100 ACT4_064_00080 ACT4_038_00400 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | ACT4_038_00390 ACT4_036_01090 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | ACT4_021_01950 ACT4_020_00340 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | ACT4_020_00340 ACT4_019_00570 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | ACT4_010_00390 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | ACT4_020_00330 |
RIBE (NRULE_0204) | Riboflavin synthase | ACT4_010_00420 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | ACT4_001_00070 |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | ACT4_021_03500 ACT4_038_00440 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | ACT4_047_00070 ACT4_036_00780 ACT4_038_00460 ACT4_052_00380 ACT4_040_00190 ACT4_052_00360 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | ACT4_001_01480 ACT4_021_02980 ACT4_021_00450 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | ACT4_028_00950 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | ACT4_023_01680 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | ACT4_023_00560 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | ACT4_033_00570 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | ACT4_005_00490 |
