Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | EAE_08475 EAE_22095 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_15875 EAE_14995 EAE_11915 EAE_19885 EAE_20500 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | EAE_01595 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_15885 EAE_19225 EAE_03045 EAE_19895 EAE_02325 EAE_03055 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_11915 EAE_20500 EAE_19885 EAE_15875 EAE_14995 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_19895 EAE_02325 EAE_03045 EAE_03055 EAE_15885 EAE_19225 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EAE_05090 EAE_21420 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | EAE_21415 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_15875 EAE_14995 EAE_11915 EAE_20500 EAE_19885 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_02325 EAE_03055 EAE_15885 EAE_19895 EAE_19225 EAE_03045 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | EAE_01360 EAE_20445 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | EAE_15885 EAE_02325 EAE_19895 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | EAE_02330 EAE_19890 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_11915 EAE_19885 EAE_15875 EAE_14995 EAE_20500 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_03055 EAE_19895 EAE_02325 EAE_19225 EAE_15885 EAE_03045 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | EAE_23970 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | EAE_00555 EAE_23975 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | EAE_23970 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | EAE_23970 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | EAE_23975 EAE_00555 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | EAE_14295 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | EAE_14300 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | EAE_03655 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | EAE_19890 |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | EAE_19880 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | EAE_19885 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_15875 EAE_11915 EAE_14995 EAE_19885 EAE_20500 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_15885 EAE_03045 EAE_19225 EAE_19895 EAE_02325 EAE_03055 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | EAE_12120 |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | EAE_13515 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | EAE_13520 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | EAE_14450 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | EAE_14440 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | EAE_18360 EAE_14460 |
BIOB (NRULE_0185) | Biotin synthase | EAE_14445 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EAE_19900 |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | EAE_19910 |
CATC (NRULE_0054) | Muconolactone isomerase | EAE_19905 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EAE_18190 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_20470 EAE_18180 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EAE_19900 |
CATC (NRULE_0054) | Muconolactone isomerase | EAE_19905 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EAE_18190 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_20470 EAE_18180 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | EAE_19910 |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EAE_19900 |
CATC (NRULE_0054) | Muconolactone isomerase | EAE_19905 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_20470 EAE_18180 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | EAE_19910 |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EAE_19900 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | EAE_19910 |
CATC (NRULE_0054) | Muconolactone isomerase | EAE_19905 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_18180 EAE_20470 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | EAE_12120 |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chloramphenicol resistance(NFUNC_0025) |
| 必須 | A | CAT1 (NRULE_0107) | Chloramphenicol acetyltransferase | EAE_17595 |
|---|
| B | CAT4 (NRULE_0108) | Chloramphenicol acetyltransferase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_18180 EAE_20470 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | EAE_17350 EAE_09385 EAE_07980 EAE_00505 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | EAE_19910 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_18180 EAE_20470 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | EAE_00505 EAE_17350 EAE_09385 EAE_07980 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_10310 EAE_16010 EAE_02345 EAE_03415 EAE_19960 EAE_14600 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | EAE_03610 EAE_10345 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | EAE_03610 EAE_10345 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Extracellular electron transfer system(NFUNC_0098) |
| 必須 | A | NAPC (NRULE_0333) | Multiheme c-type cytochrome | EAE_01205 |
|---|
MTRC (NRULE_0334) | OmcA/MtrC family decaheme c-type cytochrome | |
MTRA (NRULE_0335) | MtrA/DmsE family decaheme c-type cytochrome | |
MTRB (NRULE_0336) | Outer membrane protein MtrB homolog | |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EAE_21420 EAE_05090 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | EAE_04320 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | EAE_18090 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EAE_03660 EAE_24500 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EAE_11500 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EAE_24575 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EAE_22580 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EAE_16390 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | EAE_05090 EAE_21420 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EAE_04320 |
FOLA (NRULE_0147) | Dihydrofolate reductase | EAE_11010 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EAE_24500 EAE_03660 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EAE_11500 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EAE_24575 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EAE_22580 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EAE_16390 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | EAE_21420 EAE_05090 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EAE_04320 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EAE_24500 EAE_03660 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EAE_11500 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EAE_24575 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EAE_22580 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EAE_16390 |
Fosfomycin resistance(NFUNC_0023) |
| 必須 | A | FOSA (NRULE_0098) | Glutathione transferase FosA | EAE_10155 |
|---|
| B | FOSB (NRULE_0099) | Metallothiol transferase FosB | |
| C | FOSX (NRULE_0100) | Fosfomycin resistance protein FosX | |
Histamine biosynthesis(NFUNC_0078) |
| 必須 | A | HDCA (NRULE_0244) | Histidine decarboxylase proenzyme | |
|---|
| B | HDC (NRULE_0245) | Histidine decarboxylase | EAE_02560 |
| 任意 | | HDCP (NRULE_0246) | Histidine/histamine antiporter | EAE_02555 |
|---|
| | HDCB (NRULE_0247) | HdcB protein | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | EAE_14295 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | EAE_14300 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EAE_10315 |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EAE_10310 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EAE_10345 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EAE_10315 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EAE_10310 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EAE_10315 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_14600 EAE_02345 EAE_03415 EAE_10310 EAE_16010 EAE_19960 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EAE_10345 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EAE_10315 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_16010 EAE_19960 EAE_02345 EAE_03415 EAE_10310 EAE_14600 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_03415 EAE_02345 EAE_19960 EAE_10310 EAE_16010 EAE_14600 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_19960 EAE_14600 EAE_16010 EAE_03415 EAE_02345 EAE_10310 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EAE_10345 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EAE_10310 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EAE_10310 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EAE_10345 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EAE_10350 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EAE_10340 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EAE_10335 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EAE_10330 |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | EAE_22630 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | EAE_15020 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | EAE_15025 |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | EAE_14310 EAE_14330 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EAE_14310 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EAE_00420 EAE_24345 EAE_17195 EAE_14320 EAE_06495 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | EAE_13055 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | EAE_08560 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | EAE_04815 |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | EAE_05740 |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | EAE_00790 |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EAE_24345 EAE_00420 EAE_06495 EAE_14320 EAE_17195 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EAE_14310 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | EAE_14325 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | EAE_14330 |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | EAE_19895 EAE_02325 EAE_15885 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | EAE_02330 EAE_19890 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | EAE_10345 EAE_03610 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | EAE_15885 EAE_02325 EAE_19895 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | EAE_02330 EAE_19890 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | EAE_10345 EAE_03610 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_15875 EAE_11915 EAE_19885 EAE_20500 EAE_14995 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_02325 EAE_19895 EAE_19225 EAE_15885 EAE_03055 EAE_03045 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | EAE_24060 EAE_10245 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | EAE_11485 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | EAE_11495 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | EAE_12600 EAE_16640 |
PANC (NRULE_0118) | Pantothenate synthetase | EAE_11490 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | EAE_10315 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | EAE_03025 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_15875 EAE_19885 EAE_20500 EAE_11915 EAE_14995 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_19225 EAE_19895 EAE_15885 EAE_03055 EAE_03045 EAE_02325 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EAE_10310 EAE_02345 EAE_03415 EAE_14600 EAE_19960 EAE_16010 |
Polymyxin resistance(NFUNC_0036) |
| 必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | EAE_05690 |
|---|
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | EAE_05700 |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | EAE_05695 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | EAE_05685 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | EAE_05675 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | EAE_05670 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | EAE_05680 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | EAE_20290 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | EAE_20285 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | EAE_18185 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | EAE_18195 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EAE_18190 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_20470 EAE_18180 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | EAE_20290 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | EAE_20285 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | EAE_18185 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EAE_18170 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EAE_18175 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EAE_20470 EAE_18180 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
| 必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | EAE_19565 |
|---|
| 任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | EAE_19555 |
|---|
| | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | EAE_19560 |
| | PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | EAE_19570 |
| | PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | EAE_19575 |
| | PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | EAE_19580 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | EAE_03615 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | EAE_21325 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | EAE_12540 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | EAE_12545 |
RIBE (NRULE_0204) | Riboflavin synthase | EAE_17765 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | EAE_10840 |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | EAE_20245 |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | EAE_20245 |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | EAE_11915 EAE_19885 EAE_15875 EAE_14995 EAE_20500 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | EAE_10490 |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EAE_15885 EAE_19895 EAE_19225 EAE_03055 EAE_03045 EAE_02325 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | EAE_05390 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | EAE_22940 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | EAE_22945 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | EAE_01445 |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | EAE_01440 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | EAE_01435 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | EAE_15890 EAE_13530 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | EAE_08750 |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | EAE_16055 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | EAE_02970 |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | EAE_24600 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | EAE_15140 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | EAE_11030 EAE_18605 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | EAE_00915 |
