Acid resistance (by GABA antiporter)(NFUNC_0071) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | SIAM614_02556 |
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | SIAM614_11183 |
n-alkane hydroxylation(NFUNC_0008) |
必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_30836 SIAM614_13893 SIAM614_12153 SIAM614_30616 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
任意 | | RUBA (NRULE_0039) | Rubredoxin | SIAM614_29556 |
| RUBB (NRULE_0040) | Rubredoxin reductase | |
| MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_02421 SIAM614_21140 SIAM614_12148 SIAM614_30621 SIAM614_22982 SIAM614_22987 SIAM614_23002 SIAM614_16407 SIAM614_30821 |
D-allose biosynthesis(NFUNC_0077) |
必須 | A | LRHI (NRULE_0242) | L-rhamnose isomerase | SIAM614_17824 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | SIAM614_27433 |
B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SIAM614_09023 |
任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_12153 SIAM614_13893 SIAM614_30616 SIAM614_30836 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_02421 SIAM614_22982 SIAM614_22987 SIAM614_23002 SIAM614_21140 SIAM614_12148 SIAM614_16407 SIAM614_30821 SIAM614_30621 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | SIAM614_11853 |
TRPE (NRULE_0143) | Anthranilate synthase component I | SIAM614_11853 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_12153 SIAM614_13893 SIAM614_30836 SIAM614_30616 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_12148 SIAM614_22982 SIAM614_30821 SIAM614_22987 SIAM614_23002 SIAM614_02421 SIAM614_16407 SIAM614_21140 SIAM614_30621 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
Arginine degradation(NFUNC_0074) |
必須 | A | ARGI (NRULE_0239) | Arginase | SIAM614_27572 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | SIAM614_26623 SIAM614_19776 SIAM614_29186 |
B | AZR (NRULE_0237) | NADPH azoreductase | |
C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SIAM614_30821 SIAM614_30621 SIAM614_12148 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SIAM614_30826 SIAM614_30626 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_30616 SIAM614_12153 SIAM614_30836 SIAM614_13893 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_30621 SIAM614_22982 SIAM614_22987 SIAM614_23002 SIAM614_12148 SIAM614_02421 SIAM614_16407 SIAM614_21140 SIAM614_30821 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC1 (NRULE_0017) | Arsenate reductase | SIAM614_19681 |
B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | SIAM614_25167 |
C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SIAM614_23397 |
ARSC1 (NRULE_0017) | Arsenate reductase | SIAM614_19681 |
E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SIAM614_23397 |
ARSC2 (NRULE_0018) | Arsenate reductase | SIAM614_25167 |
F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SIAM614_23397 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
| ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| ARSH (NRULE_0021) | ArsH protein | SIAM614_19676 |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | SIAM614_21637 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | SIAM614_07873 |
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_13893 SIAM614_30836 SIAM614_30616 SIAM614_12153 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_16407 SIAM614_30821 SIAM614_30621 SIAM614_21140 SIAM614_22982 SIAM614_22987 SIAM614_23002 SIAM614_12148 SIAM614_02421 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SIAM614_09023 |
B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
C | BLAC (NRULE_0124) | Beta-lactamase class C | |
D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | SIAM614_05120 |
B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | SIAM614_05115 |
C | CHOX (NRULE_0178) | Choline oxidase | |
Betaine biosynthesis (from glycine)(NFUNC_0050) |
必須 | A | GSMT (NRULE_0179) | Glycine/sarcosine N-methyltransferase | |
SDMT (NRULE_0180) | Dimethylglycine N-methyltransferase | SIAM614_20226 |
B | GSDMT (NRULE_0181) | Glycine/sarcosine/dimethylglycine N-methyltransferase | |
Bioplastic degradation(NFUNC_0015) |
必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | SIAM614_27702 |
B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | |
C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
Bioplastic synthesis(NFUNC_0001) |
必須 | A | PHAC1 (NRULE_0010) | Poly(3-hydroxyalkanoate) polymerase | |
B | PHAE (NRULE_0012) | Poly(3-hydroxyalkanoate) polymerase PhaE subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
C | PHAR (NRULE_0013) | Poly(3-hydroxyalkanoate) polymerase PhaR subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
任意 | | PHAB (NRULE_0011) | Acetoacetyl-CoA reductase | SIAM614_26693 |
| PHAP1 (NRULE_0374) | Phasin | SIAM614_15687 SIAM614_05386 SIAM614_05376 |
| PHAP2 (NRULE_0375) | Phasin | |
| PHAP3 (NRULE_0376) | Phasin | |
| PHAF (NRULE_0377) | Phasin PhaF | |
| PHAI (NRULE_0378) | Phasin PhaI | |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | SIAM614_30761 |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SIAM614_01831 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SIAM614_01831 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_11098 SIAM614_04875 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | SIAM614_30761 |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | SIAM614_09023 |
| BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | SIAM614_04385 SIAM614_06953 SIAM614_13623 |
CLCE (NRULE_0384) | Maleylacetate reductase | SIAM614_30731 |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | SIAM614_30761 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | SIAM614_06953 SIAM614_04385 SIAM614_13623 |
CLCE (NRULE_0384) | Maleylacetate reductase | SIAM614_30731 |
任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_03850 SIAM614_10108 SIAM614_16532 SIAM614_30841 SIAM614_16887 |
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | SIAM614_27932 SIAM614_21802 SIAM614_21797 |
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
B | EDIO (NRULE_0058) | extradiol dioxygenase | SIAM614_21802 SIAM614_27932 SIAM614_21797 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | SIAM614_06323 |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Extracellular electron transfer system(NFUNC_0098) |
必須 | A | NAPC (NRULE_0333) | Multiheme c-type cytochrome | SIAM614_28591 |
MTRC (NRULE_0334) | OmcA/MtrC family decaheme c-type cytochrome | |
MTRA (NRULE_0335) | MtrA/DmsE family decaheme c-type cytochrome | |
MTRB (NRULE_0336) | Outer membrane protein MtrB homolog | |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | SIAM614_11853 |
DHPS (NRULE_0144) | Dihydropteroate synthase | SIAM614_25387 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SIAM614_28563 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SIAM614_25382 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SIAM614_27547 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SIAM614_04270 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | SIAM614_11853 |
DHPS (NRULE_0144) | Dihydropteroate synthase | SIAM614_25387 |
FOLA (NRULE_0147) | Dihydrofolate reductase | SIAM614_19396 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SIAM614_28563 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SIAM614_25382 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SIAM614_27547 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SIAM614_04270 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
C | GLAT (NRULE_0142) | Glutamine amidotransferase | SIAM614_11853 |
DHPS (NRULE_0144) | Dihydropteroate synthase | SIAM614_25387 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SIAM614_28563 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SIAM614_25382 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SIAM614_27547 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SIAM614_04270 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | SIAM614_02556 |
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | SIAM614_31121 SIAM614_17149 |
B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | SIAM614_06063 |
Histamine biosynthesis(NFUNC_0078) |
必須 | A | HDCA (NRULE_0244) | Histidine decarboxylase proenzyme | SIAM614_11398 |
B | HDC (NRULE_0245) | Histidine decarboxylase | |
任意 | | HDCP (NRULE_0246) | Histidine/histamine antiporter | |
| HDCB (NRULE_0247) | HdcB protein | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
| GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| GALE (NRULE_0111) | UDP-glucose 4-epimerase | SIAM614_21637 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21797 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21802 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_03850 SIAM614_16532 SIAM614_30841 SIAM614_16887 SIAM614_10108 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21797 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_03850 SIAM614_10108 SIAM614_16532 SIAM614_30841 SIAM614_16887 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21802 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_16887 SIAM614_10108 SIAM614_03850 SIAM614_16532 SIAM614_30841 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21802 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_16887 SIAM614_10108 SIAM614_03850 SIAM614_16532 SIAM614_30841 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21797 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21802 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | SIAM614_21797 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | SIAM614_21792 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | SIAM614_21787 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | SIAM614_21817 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | SIAM614_21822 |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
D | ERE (NRULE_0168) | Erythromycin esterase | SIAM614_01604 |
E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | SIAM614_09978 SIAM614_01901 SIAM614_22287 SIAM614_28052 SIAM614_11493 SIAM614_22882 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | SIAM614_30091 SIAM614_23302 SIAM614_20850 SIAM614_22362 SIAM614_07218 SIAM614_24907 |
D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | SIAM614_07908 |
F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | SIAM614_09498 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | SIAM614_30091 SIAM614_24907 SIAM614_20850 SIAM614_22362 SIAM614_07218 SIAM614_23302 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | SIAM614_28047 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | SIAM614_28052 |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SIAM614_30621 SIAM614_12148 SIAM614_30821 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SIAM614_30826 SIAM614_30626 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | SIAM614_21802 SIAM614_27932 SIAM614_21797 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SIAM614_30821 SIAM614_12148 SIAM614_30621 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SIAM614_30626 SIAM614_30826 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | SIAM614_21797 SIAM614_27932 SIAM614_21802 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_30616 SIAM614_12153 SIAM614_13893 SIAM614_30836 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_23002 SIAM614_22982 SIAM614_02421 SIAM614_12148 SIAM614_22987 SIAM614_16407 SIAM614_21140 SIAM614_30621 SIAM614_30821 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
Nitrile hydratase(NFUNC_0002) |
必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | SIAM614_09388 |
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | SIAM614_09383 |
任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | SIAM614_09378 |
| COBW (NRULE_0007) | CobW/P47K family protein | SIAM614_27163 SIAM614_13538 SIAM614_19119 SIAM614_24222 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | SIAM614_04185 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | SIAM614_26396 |
PANC (NRULE_0118) | Pantothenate synthetase | SIAM614_04180 |
Penicillin resistance(NFUNC_0047) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SIAM614_09023 |
B | BLAD (NRULE_0125) | Beta-lactamase class D | |
任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Phenol degradation(NFUNC_0028) |
必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | SIAM614_12048 |
C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | SIAM614_03563 |
任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | SIAM614_24712 |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_12153 SIAM614_13893 SIAM614_30836 SIAM614_30616 |
| MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_02421 SIAM614_30821 SIAM614_30621 SIAM614_21140 SIAM614_22982 SIAM614_22987 SIAM614_23002 SIAM614_12148 SIAM614_16407 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SIAM614_16887 SIAM614_10108 SIAM614_03850 SIAM614_16532 SIAM614_30841 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | SIAM614_01816 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | SIAM614_01821 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | SIAM614_01826 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SIAM614_01831 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_04875 SIAM614_11098 |
B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | SIAM614_01816 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | SIAM614_01821 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | SIAM614_04865 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SIAM614_11098 SIAM614_04875 |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | SIAM614_06963 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | SIAM614_06963 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | SIAM614_10428 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | SIAM614_10438 |
RIBE (NRULE_0204) | Riboflavin synthase | SIAM614_10433 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | SIAM614_05968 |
Streptomycin resistance(NFUNC_0054) |
必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
C | APH6 (NRULE_0155) | Streptomycin 6-kinase | SIAM614_27433 |
任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
Thiocyanate hydrolase(NFUNC_0003) |
必須 | A | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | SIAM614_09378 SIAM614_09383 |
SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | SIAM614_09378 SIAM614_09383 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
B | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | SIAM614_09383 SIAM614_09378 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
C | SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | SIAM614_09383 SIAM614_09378 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | SIAM614_30616 SIAM614_30836 SIAM614_12153 SIAM614_13893 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | SIAM614_01836 |
任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SIAM614_23002 SIAM614_30821 SIAM614_30621 SIAM614_21140 SIAM614_16407 SIAM614_02421 SIAM614_12148 SIAM614_22987 SIAM614_22982 |
Uptake of osmoprotectant(NFUNC_0061) |
必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | SIAM614_23262 |
B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
C | BCCT (NRULE_0220) | BCCT family transporter | SIAM614_24242 |
D | PROP (NRULE_0221) | Osmoprotectant transporter | |
E | OPUE (NRULE_0222) | Sodium/proline symporter | |
F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | SIAM614_17844 SIAM614_11253 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | SIAM614_19094 |