Acid resistance (by GABA antiporter)(NFUNC_0071) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | WFL_18460 WFL_07935 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | WFL_07930 |
Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | WFL_21485 WFL_06245 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_09690 WFL_04775 WFL_07455 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | WFL_14195 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_09685 WFL_13535 WFL_13545 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_04775 WFL_09690 WFL_07455 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_13545 WFL_13535 WFL_09685 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | WFL_06605 WFL_17660 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | WFL_06610 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_09690 WFL_04775 WFL_07455 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_09685 WFL_13545 WFL_13535 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | WFL_07530 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | WFL_13535 WFL_09685 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | WFL_13540 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_04775 WFL_09690 WFL_07455 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_09685 WFL_13535 WFL_13545 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | WFL_18375 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | WFL_13315 WFL_18380 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | WFL_18375 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | WFL_18375 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | WFL_18380 WFL_13315 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | WFL_03940 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | WFL_10740 WFL_03945 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | WFL_16240 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_09690 WFL_07455 WFL_04775 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_09685 WFL_13535 WFL_13545 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | WFL_21965 |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | WFL_01890 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | WFL_01895 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | WFL_04030 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | WFL_04020 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | WFL_08610 WFL_04040 |
BIOB (NRULE_0185) | Biotin synthase | WFL_04025 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | WFL_21965 |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | WFL_06950 WFL_22140 WFL_20155 WFL_15990 WFL_13190 WFL_06945 WFL_02720 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | WFL_02720 WFL_06950 WFL_22140 WFL_20155 WFL_15990 WFL_13190 WFL_06945 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_07780 WFL_22915 WFL_05450 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | WFL_02095 WFL_16155 WFL_22950 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | WFL_02100 |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | WFL_02105 |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | WFL_02115 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | WFL_02110 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | WFL_02095 WFL_16155 WFL_22950 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | WFL_02105 |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | WFL_02115 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | WFL_02110 |
Extracellular electron transfer system(NFUNC_0098) |
| 必須 | A | NAPC (NRULE_0333) | Multiheme c-type cytochrome | WFL_11760 WFL_10055 WFL_05395 |
|---|
MTRC (NRULE_0334) | OmcA/MtrC family decaheme c-type cytochrome | |
MTRA (NRULE_0335) | MtrA/DmsE family decaheme c-type cytochrome | |
MTRB (NRULE_0336) | Outer membrane protein MtrB homolog | |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | WFL_06605 WFL_17660 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | WFL_16870 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | WFL_08675 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | WFL_12200 WFL_16245 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | WFL_00685 |
FOLC (NRULE_0160) | Bifunctional protein FolC | WFL_12260 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | WFL_09735 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | WFL_05880 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | WFL_06605 WFL_17660 |
DHPS (NRULE_0144) | Dihydropteroate synthase | WFL_16870 |
FOLA (NRULE_0147) | Dihydrofolate reductase | WFL_00240 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | WFL_16245 WFL_12200 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | WFL_00685 |
FOLC (NRULE_0160) | Bifunctional protein FolC | WFL_12260 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | WFL_09735 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | WFL_05880 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | WFL_17660 WFL_06605 |
DHPS (NRULE_0144) | Dihydropteroate synthase | WFL_16870 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | WFL_12200 WFL_16245 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | WFL_00685 |
FOLC (NRULE_0160) | Bifunctional protein FolC | WFL_12260 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | WFL_09735 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | WFL_05880 |
GABA biosynthesis(NFUNC_0066) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | WFL_07935 WFL_18460 |
|---|
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | WFL_03940 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | WFL_03945 WFL_10740 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | WFL_22920 |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | WFL_22915 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | WFL_22950 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | WFL_22920 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | WFL_22915 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | WFL_22920 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_22915 WFL_07780 WFL_05450 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | WFL_22950 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | WFL_22920 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_07780 WFL_22915 WFL_05450 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_05450 WFL_07780 WFL_22915 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_22915 WFL_07780 WFL_05450 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | WFL_22950 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | WFL_22915 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | WFL_22915 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | WFL_22950 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | WFL_22955 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | WFL_22945 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | WFL_22960 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | WFL_22940 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | WFL_22935 |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | WFL_09785 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | WFL_04805 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | WFL_04810 |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | WFL_03975 WFL_03955 WFL_06895 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | WFL_03955 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | WFL_21385 WFL_03965 WFL_12990 WFL_20815 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | WFL_02775 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | WFL_21535 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | WFL_17385 |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | WFL_18280 |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | WFL_13500 |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | WFL_21385 WFL_03965 WFL_20815 WFL_12990 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | WFL_03955 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | WFL_03970 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | WFL_03975 |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | WFL_10825 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | WFL_09685 WFL_13535 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | WFL_13540 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | WFL_16155 WFL_02095 WFL_22950 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | WFL_13535 WFL_09685 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | WFL_13540 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | WFL_02095 WFL_22950 WFL_16155 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_07455 WFL_04775 WFL_09690 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_09685 WFL_13545 WFL_13535 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | WFL_22900 WFL_11620 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | WFL_00630 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | WFL_00645 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | WFL_02445 |
PANC (NRULE_0118) | Pantothenate synthetase | WFL_00640 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | WFL_22920 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | WFL_02090 |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | WFL_13555 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_07455 WFL_09690 WFL_04775 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_13535 WFL_13545 WFL_09685 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | WFL_22915 WFL_07780 WFL_05450 |
Phytic acid hydrolysis(NFUNC_0085) |
| 必須 | A | PHYT (NRULE_0258) | 3-phytase | |
|---|
| B | APPA (NRULE_0259) | Periplasmic AppA protein | WFL_05315 |
Polymyxin resistance(NFUNC_0036) |
| 必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | WFL_11970 |
|---|
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | WFL_11960 |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | WFL_11965 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | WFL_11975 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | WFL_11985 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | WFL_11990 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | WFL_11980 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | WFL_07480 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | WFL_16170 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | WFL_06680 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | WFL_02390 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | WFL_02395 |
RIBE (NRULE_0204) | Riboflavin synthase | WFL_08970 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | WFL_00125 |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | WFL_07455 WFL_09690 WFL_04775 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | WFL_13545 WFL_09685 WFL_13535 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | WFL_18035 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | WFL_10160 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | WFL_10165 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | WFL_14055 |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | WFL_14050 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | WFL_14045 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | WFL_00200 WFL_09680 WFL_01905 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | WFL_21750 |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | WFL_05495 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | WFL_15535 |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | WFL_12285 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | WFL_04945 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | WFL_00260 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | WFL_13665 |
