Acid resistance (by GABA antiporter)(NFUNC_0071) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | GONAM_15_00190 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | GONAM_10_02240 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | GONAM_02_01570 |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GONAM_19_00670 GONAM_19_00650 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GONAM_19_00670 GONAM_19_00650 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_25_00290 GONAM_07_00740 GONAM_06_01170 GONAM_11_00410 GONAM_19_00660 GONAM_19_00870 GONAM_10_01700 GONAM_35_00350 GONAM_54_00150 GONAM_61_00010 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GONAM_19_00680 |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_25_00310 GONAM_03_00230 GONAM_07_00390 GONAM_07_00730 GONAM_20_00120 GONAM_29_00270 GONAM_31_00120 GONAM_56_00210 GONAM_61_00150 GONAM_20_00460 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| 必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | GONAM_33_00100 |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_19_00870 GONAM_06_01170 GONAM_07_00740 GONAM_10_01700 GONAM_11_00410 GONAM_19_00660 GONAM_25_00290 GONAM_35_00350 GONAM_54_00150 GONAM_61_00010 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_07_00390 GONAM_20_00460 GONAM_20_00120 GONAM_07_00730 GONAM_03_00230 GONAM_61_00150 GONAM_56_00210 GONAM_31_00120 GONAM_29_00270 GONAM_25_00310 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | GONAM_52_00520 GONAM_02_03280 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | GONAM_27_00160 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_54_00150 GONAM_25_00290 GONAM_35_00350 GONAM_19_00660 GONAM_07_00740 GONAM_10_01700 GONAM_06_01170 GONAM_61_00010 GONAM_11_00410 GONAM_19_00870 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_07_00390 GONAM_20_00120 GONAM_20_00460 GONAM_25_00310 GONAM_29_00270 GONAM_31_00120 GONAM_07_00730 GONAM_61_00150 GONAM_56_00210 GONAM_03_00230 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GONAM_25_00310 GONAM_20_00460 GONAM_03_00230 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GONAM_20_00450 GONAM_25_00300 GONAM_03_00240 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_35_00350 GONAM_06_01170 GONAM_07_00740 GONAM_10_01700 GONAM_11_00410 GONAM_19_00660 GONAM_19_00870 GONAM_25_00290 GONAM_54_00150 GONAM_61_00010 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_61_00150 GONAM_07_00390 GONAM_07_00730 GONAM_20_00120 GONAM_20_00460 GONAM_03_00230 GONAM_25_00310 GONAM_29_00270 GONAM_31_00120 GONAM_56_00210 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | GONAM_24_00050 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GONAM_02_01770 |
ARSC1 (NRULE_0017) | Arsenate reductase | GONAM_24_00050 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GONAM_02_01770 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GONAM_02_01770 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | GONAM_15_01770 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | GONAM_44_00310 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | GONAM_25_00310 |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | GONAM_25_00300 |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | GONAM_25_00290 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | GONAM_25_00290 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_06_01170 GONAM_10_01700 GONAM_11_00410 GONAM_19_00660 GONAM_19_00870 GONAM_25_00290 GONAM_35_00350 GONAM_07_00740 GONAM_61_00010 GONAM_54_00150 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_03_00230 GONAM_31_00120 GONAM_56_00210 GONAM_61_00150 GONAM_07_00390 GONAM_07_00730 GONAM_20_00120 GONAM_20_00460 GONAM_25_00310 GONAM_29_00270 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | GONAM_07_01260 |
| C | CHOX (NRULE_0178) | Choline oxidase | GONAM_07_01270 |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | GONAM_46_00210 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | GONAM_46_00230 |
BIOB (NRULE_0185) | Biotin synthase | GONAM_46_00240 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | GONAM_24_00060 GONAM_25_00340 |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | GONAM_25_00350 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GONAM_25_00250 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_20_00330 GONAM_25_00260 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_23_00530 GONAM_25_00240 GONAM_61_00670 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | GONAM_24_00060 GONAM_25_00340 |
CATC (NRULE_0054) | Muconolactone isomerase | GONAM_25_00350 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GONAM_25_00250 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_25_00260 GONAM_20_00330 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_61_00670 GONAM_25_00240 GONAM_23_00530 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | GONAM_25_00340 GONAM_24_00060 |
CATC (NRULE_0054) | Muconolactone isomerase | GONAM_25_00350 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_25_00260 GONAM_20_00330 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_61_00670 GONAM_25_00240 GONAM_23_00530 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | GONAM_25_00340 GONAM_24_00060 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | GONAM_25_00350 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_25_00260 GONAM_20_00330 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_23_00530 GONAM_25_00240 GONAM_61_00670 |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_20_00330 GONAM_25_00260 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_61_00670 GONAM_25_00240 GONAM_23_00530 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | GONAM_22_00480 GONAM_10_00840 GONAM_10_00550 GONAM_08_00320 GONAM_56_00390 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_25_00260 GONAM_20_00330 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_23_00530 GONAM_25_00240 GONAM_61_00670 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | GONAM_22_00480 GONAM_56_00390 GONAM_10_00550 GONAM_08_00320 GONAM_10_00840 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_61_00640 GONAM_07_00360 GONAM_07_00640 GONAM_08_00500 GONAM_10_02390 GONAM_10_01690 GONAM_16_01250 GONAM_24_00080 GONAM_41_00050 GONAM_55_00090 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | GONAM_03_00170 GONAM_07_00370 GONAM_08_00560 GONAM_24_00230 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | GONAM_07_00500 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | GONAM_07_00510 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | GONAM_24_00230 GONAM_03_00170 GONAM_07_00370 GONAM_08_00560 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | GONAM_07_00500 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | GONAM_07_00510 |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | GONAM_16_00910 |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | GONAM_16_00920 |
ECTC (NRULE_0188) | L-ectoine synthase | GONAM_16_00900 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | GONAM_52_00520 GONAM_02_03280 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | GONAM_09_00070 GONAM_34_00260 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GONAM_34_00270 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GONAM_34_00280 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GONAM_16_00800 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | GONAM_02_03280 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | GONAM_52_00520 GONAM_02_03280 |
DHPS (NRULE_0144) | Dihydropteroate synthase | GONAM_34_00260 GONAM_09_00070 |
FOLA (NRULE_0147) | Dihydrofolate reductase | GONAM_14_01260 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GONAM_34_00270 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GONAM_34_00280 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GONAM_16_00800 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | GONAM_02_03280 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | GONAM_52_00520 GONAM_02_03280 |
DHPS (NRULE_0144) | Dihydropteroate synthase | GONAM_09_00070 GONAM_34_00260 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GONAM_34_00270 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GONAM_34_00280 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GONAM_16_00800 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | GONAM_02_03280 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | GONAM_15_00190 |
|---|
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | GONAM_15_00840 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | GONAM_15_01770 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | GONAM_16_00910 |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | GONAM_16_00920 |
| | ECTC (NRULE_0188) | L-ectoine synthase | GONAM_16_00900 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_41_00050 GONAM_61_00640 GONAM_55_00090 GONAM_24_00080 GONAM_16_01250 GONAM_10_01690 GONAM_10_02390 GONAM_08_00500 GONAM_07_00640 GONAM_07_00360 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_24_00080 GONAM_41_00050 GONAM_61_00640 GONAM_55_00090 GONAM_07_00360 GONAM_07_00640 GONAM_08_00500 GONAM_10_02390 GONAM_10_01690 GONAM_16_01250 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_16_01250 GONAM_24_00080 GONAM_41_00050 GONAM_55_00090 GONAM_61_00640 GONAM_07_00360 GONAM_07_00640 GONAM_08_00500 GONAM_10_02390 GONAM_10_01690 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_55_00090 GONAM_41_00050 GONAM_24_00080 GONAM_16_01250 GONAM_10_02390 GONAM_10_01690 GONAM_07_00360 GONAM_61_00640 GONAM_07_00640 GONAM_08_00500 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | GONAM_09_00110 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | GONAM_09_01500 GONAM_56_00750 GONAM_56_00720 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | GONAM_09_01470 GONAM_56_00730 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | GONAM_23_00180 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | GONAM_09_01470 GONAM_56_00730 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | GONAM_56_00740 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | GONAM_04_00060 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GONAM_20_00460 GONAM_25_00310 GONAM_03_00230 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GONAM_20_00450 GONAM_03_00240 GONAM_25_00300 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | GONAM_07_00370 GONAM_24_00230 GONAM_08_00560 GONAM_03_00170 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GONAM_20_00460 GONAM_25_00310 GONAM_03_00230 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GONAM_03_00240 GONAM_25_00300 GONAM_20_00450 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | GONAM_03_00170 GONAM_07_00370 GONAM_08_00560 GONAM_24_00230 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_07_00740 GONAM_06_01170 GONAM_10_01700 GONAM_11_00410 GONAM_19_00660 GONAM_19_00870 GONAM_25_00290 GONAM_35_00350 GONAM_54_00150 GONAM_61_00010 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_61_00150 GONAM_29_00270 GONAM_31_00120 GONAM_56_00210 GONAM_25_00310 GONAM_20_00460 GONAM_20_00120 GONAM_07_00730 GONAM_07_00390 GONAM_03_00230 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | GONAM_08_00660 GONAM_53_00070 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | GONAM_11_02220 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | GONAM_32_00230 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | |
PANC (NRULE_0118) | Pantothenate synthetase | GONAM_11_02230 GONAM_11_00595 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GONAM_19_00670 GONAM_19_00650 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GONAM_19_00670 GONAM_19_00650 |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | GONAM_24_00070 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | GONAM_07_00850 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_07_00740 GONAM_11_00410 GONAM_19_00660 GONAM_19_00870 GONAM_25_00290 GONAM_35_00350 GONAM_54_00150 GONAM_61_00010 GONAM_06_01170 GONAM_10_01700 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GONAM_19_00680 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_20_00460 GONAM_25_00310 GONAM_29_00270 GONAM_31_00120 GONAM_56_00210 GONAM_61_00150 GONAM_20_00120 GONAM_03_00230 GONAM_07_00730 GONAM_07_00390 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GONAM_61_00640 GONAM_07_00360 GONAM_07_00640 GONAM_08_00500 GONAM_10_02390 GONAM_10_01690 GONAM_16_01250 GONAM_24_00080 GONAM_41_00050 GONAM_55_00090 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | GONAM_20_00380 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | GONAM_20_00390 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | GONAM_20_00360 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GONAM_25_00250 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_20_00330 GONAM_25_00260 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_23_00530 GONAM_25_00240 GONAM_61_00670 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | GONAM_20_00380 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | GONAM_20_00390 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GONAM_20_00330 GONAM_25_00260 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | GONAM_20_00330 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GONAM_23_00530 GONAM_25_00240 GONAM_61_00670 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | GONAM_10_02400 GONAM_55_00030 GONAM_12_00470 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | GONAM_12_00470 GONAM_55_00030 GONAM_02_02300 GONAM_10_02400 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | GONAM_12_00460 |
RIBE (NRULE_0204) | Riboflavin synthase | GONAM_12_00480 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | GONAM_14_01430 |
|---|
Streptomycin resistance(NFUNC_0054) |
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | GONAM_33_00100 |
| 任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
|---|
Thiocyanate hydrolase(NFUNC_0003) |
| 必須 | A | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | GONAM_53_00370 |
|---|
SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | GONAM_53_00370 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | GONAM_53_00360 |
| B | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | GONAM_53_00370 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | GONAM_53_00360 |
| C | SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | GONAM_53_00370 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | GONAM_53_00360 |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GONAM_19_00670 GONAM_19_00650 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GONAM_19_00670 GONAM_19_00650 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | GONAM_25_00290 GONAM_19_00660 GONAM_19_00870 GONAM_06_01170 GONAM_07_00740 GONAM_10_01700 GONAM_11_00410 GONAM_61_00010 GONAM_54_00150 GONAM_35_00350 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GONAM_19_00680 |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GONAM_31_00120 GONAM_56_00210 GONAM_61_00150 GONAM_20_00120 GONAM_07_00730 GONAM_07_00390 GONAM_03_00230 GONAM_20_00460 GONAM_25_00310 GONAM_29_00270 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | GONAM_46_00170 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | GONAM_46_00060 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | GONAM_46_00180 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | GONAM_22_00270 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | GONAM_22_00280 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | GONAM_07_01250 GONAM_23_00230 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | GONAM_48_00040 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| 必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | GONAM_14_00160 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | GONAM_14_00110 |
