Acid resistance (by GABA antiporter)(NFUNC_0071) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | AMIS_46640 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | AMIS_6660 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | AMIS_28610 |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_55300 AMIS_43460 AMIS_19150 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_70000 AMIS_1510 AMIS_14230 AMIS_16050 AMIS_16280 AMIS_19170 AMIS_38510 AMIS_57270 |
D-allose biosynthesis(NFUNC_0077) |
| 必須 | A | LRHI (NRULE_0242) | L-rhamnose isomerase | AMIS_37470 |
|---|
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)(NFUNC_0041) |
| 必須 | A | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | AMIS_23580 AMIS_27610 |
|---|
| B | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)(NFUNC_0042) |
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
| C | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | AMIS_30840 AMIS_47970 |
| D | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AMIS_31990 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_19150 AMIS_55300 AMIS_43460 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_38510 AMIS_1510 AMIS_14230 AMIS_16050 AMIS_16280 AMIS_19170 AMIS_57270 AMIS_70000 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | AMIS_480 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | AMIS_15620 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_19150 AMIS_43460 AMIS_55300 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_16050 AMIS_38510 AMIS_19170 AMIS_1510 AMIS_70000 AMIS_57270 AMIS_16280 AMIS_14230 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_43460 AMIS_55300 AMIS_19150 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_57270 AMIS_38510 AMIS_16050 AMIS_19170 AMIS_14230 AMIS_1510 AMIS_16280 AMIS_70000 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | AMIS_7260 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | AMIS_74920 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | AMIS_41350 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_55300 AMIS_19150 AMIS_43460 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_38510 AMIS_70000 AMIS_16280 AMIS_16050 AMIS_14230 AMIS_1510 AMIS_19170 AMIS_57270 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AMIS_31990 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Bioplastic degradation(NFUNC_0015) |
| 必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | |
|---|
| B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | AMIS_30650 AMIS_58840 |
| C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
| 任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
|---|
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | AMIS_62120 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | AMIS_68010 |
BIOB (NRULE_0185) | Biotin synthase | AMIS_67990 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | AMIS_31990 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | AMIS_78790 AMIS_77110 AMIS_65980 AMIS_57260 AMIS_55930 AMIS_47440 AMIS_34500 AMIS_24780 AMIS_79910 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | AMIS_78790 AMIS_24780 AMIS_34500 AMIS_47440 AMIS_55930 AMIS_57260 AMIS_65980 AMIS_77110 AMIS_79910 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_27160 AMIS_19210 AMIS_80330 AMIS_65510 AMIS_65100 AMIS_57160 AMIS_51420 AMIS_49910 AMIS_39660 AMIS_27310 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | AMIS_28820 AMIS_19200 AMIS_45820 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | AMIS_19100 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | AMIS_19110 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | AMIS_19200 AMIS_45820 AMIS_28820 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | AMIS_19100 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | AMIS_19110 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | AMIS_480 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | AMIS_77880 AMIS_50270 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AMIS_77870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AMIS_77860 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AMIS_11300 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | AMIS_480 |
DHPS (NRULE_0144) | Dihydropteroate synthase | AMIS_50270 AMIS_77880 |
FOLA (NRULE_0147) | Dihydrofolate reductase | AMIS_68230 AMIS_23410 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AMIS_77870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AMIS_77860 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AMIS_11300 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | AMIS_480 |
DHPS (NRULE_0144) | Dihydropteroate synthase | AMIS_77880 AMIS_50270 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | AMIS_77870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | AMIS_77860 |
FOLC (NRULE_0160) | Bifunctional protein FolC | AMIS_11300 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | AMIS_46640 |
|---|
Gentamicin resistance(NFUNC_0053) |
| 必須 | A | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | AMIS_30840 AMIS_47970 |
|---|
| 任意 | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | AMIS_23580 AMIS_27610 |
|---|
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | AMIS_7260 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | AMIS_74920 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_80330 AMIS_39660 AMIS_49910 AMIS_51420 AMIS_57160 AMIS_65100 AMIS_65510 AMIS_19210 AMIS_27160 AMIS_27310 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_57160 AMIS_65100 AMIS_65510 AMIS_80330 AMIS_51420 AMIS_49910 AMIS_39660 AMIS_27310 AMIS_27160 AMIS_19210 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_80330 AMIS_65510 AMIS_65100 AMIS_57160 AMIS_51420 AMIS_49910 AMIS_39660 AMIS_27310 AMIS_27160 AMIS_19210 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_51420 AMIS_49910 AMIS_80330 AMIS_65510 AMIS_65100 AMIS_27310 AMIS_57160 AMIS_39660 AMIS_19210 AMIS_27160 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Kanamycin resistance(NFUNC_0052) |
| 必須 | A | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
|---|
| B | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | AMIS_47970 AMIS_30840 |
| C | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| 任意 | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | AMIS_27610 AMIS_23580 |
|---|
| | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | AMIS_74790 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | AMIS_42750 AMIS_48120 |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | AMIS_22140 |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | AMIS_4900 AMIS_52800 AMIS_24870 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | AMIS_24890 AMIS_66080 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | AMIS_80050 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | AMIS_66080 AMIS_24890 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | AMIS_24880 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | AMIS_28820 AMIS_19200 AMIS_45820 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | AMIS_28820 AMIS_45820 AMIS_19200 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_55300 AMIS_43460 AMIS_19150 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_16050 AMIS_19170 AMIS_1510 AMIS_14230 AMIS_16280 AMIS_70000 AMIS_57270 AMIS_38510 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | AMIS_45540 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | AMIS_77760 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | AMIS_13480 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | AMIS_63930 |
PANC (NRULE_0118) | Pantothenate synthetase | AMIS_77770 |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | AMIS_31990 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_43460 AMIS_19150 AMIS_55300 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_14230 AMIS_16280 AMIS_1510 AMIS_19170 AMIS_38510 AMIS_57270 AMIS_70000 AMIS_16050 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | AMIS_65510 AMIS_80330 AMIS_65100 AMIS_57160 AMIS_51420 AMIS_49910 AMIS_39660 AMIS_27310 AMIS_27160 AMIS_19210 |
Phytic acid hydrolysis(NFUNC_0085) |
| 必須 | A | PHYT (NRULE_0258) | 3-phytase | AMIS_1520 |
|---|
| B | APPA (NRULE_0259) | Periplasmic AppA protein | |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | AMIS_36680 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | AMIS_36670 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | AMIS_36700 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | AMIS_36680 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | AMIS_36670 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | AMIS_42660 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | AMIS_42670 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | AMIS_42650 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | AMIS_61940 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | AMIS_50940 AMIS_60390 AMIS_13360 AMIS_61940 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | AMIS_61960 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | AMIS_61930 |
RIBE (NRULE_0204) | Riboflavin synthase | AMIS_61950 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | AMIS_69560 |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | AMIS_56140 |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | AMIS_43460 AMIS_19150 AMIS_55300 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | AMIS_57270 AMIS_70000 AMIS_19170 AMIS_1510 AMIS_14230 AMIS_16050 AMIS_16280 AMIS_38510 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | AMIS_63890 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | AMIS_63880 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | AMIS_60130 AMIS_63900 AMIS_48070 |
|---|
Trehalose biosynthesis (from maltose)(NFUNC_0034) |
| 必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase | |
|---|
TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase | |
| B | TRES (NRULE_0128) | Trehalose synthase | AMIS_54560 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | AMIS_10890 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | AMIS_74340 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | AMIS_49830 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vancomycin resistance (via D-Ala-D-Lac precursor)(NFUNC_0089) |
| 必須 | A | VANA (NRULE_0265) | D-alanine--D-lactate ligase | |
|---|
VANH (NRULE_0266) | D-specific alpha-keto acid dehydrogenase | |
VANX (NRULE_0267) | D-alanyl-D-alanine dipeptidase | |
| 任意 | | VANYA (NRULE_0274) | D-alanyl-D-alanine carboxypeptidase | |
|---|
| | VANYB (NRULE_0275) | D-alanyl-D-alanine carboxypeptidase | |
| | VANYD (NRULE_0276) | D-alanyl-D-alanine carboxypeptidase | |
| | VANY (NRULE_0277) | D-alanyl-D-alanine carboxypeptidase | |
| | VANYN (NRULE_0278) | D-alanyl-D-alanine dipeptidase/D-alanyl-D-alanine carboxypeptidase | |
| | VANRA (NRULE_0279) | Two-component system response regulator VanR | |
| | VANRB (NRULE_0280) | Two-component system response regulator VanR | |
| | VANRD (NRULE_0282) | Putative two-component system response regulator VanR | |
| | VANR (NRULE_0284) | Two-component system response regulator VanR | AMIS_51740 |
| | VANSA (NRULE_0285) | Two-component system histidine kinase VanS | |
| | VANSB (NRULE_0286) | Two-component system histidine kinase VanS | |
| | VANSD (NRULE_0288) | Putative two-component system histidine kinase VanS | |
| | VANSM (NRULE_0289) | Putative two-component system histidine kinase VanS | |
| | VANS (NRULE_0290) | Two-component system histidine kinase VanS | AMIS_51750 |
| | VANZ (NRULE_0291) | Teicoplanin resistance protein | |
| | VANW (NRULE_0292) | Putative vancomycin resistance protein | |
| | VANJ (NRULE_0295) | Teicoplanin resistance protein | |
| | VANK (NRULE_0296) | Glycyltransferase VanK | |
| | MURF2 (NRULE_0297) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| 必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | AMIS_62860 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | AMIS_62850 |
