Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | SACE_6764 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_3548 SACE_2477 SACE_2819 SACE_3556 SACE_4377 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_3272 SACE_4170 SACE_4486 SACE_4379 SACE_4512 SACE_1686 SACE_4514 SACE_3146 SACE_2821 SACE_2470 SACE_3150 |
D-allose biosynthesis(NFUNC_0077) |
| 必須 | A | LRHI (NRULE_0242) | L-rhamnose isomerase | SACE_4105 |
|---|
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)(NFUNC_0041) |
| 必須 | A | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | SACE_3603 SACE_3604 |
|---|
| B | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| 必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | SACE_6537 SACE_5997 |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SACE_1374 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_3548 SACE_4377 SACE_3556 SACE_2819 SACE_2477 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4514 SACE_1686 SACE_2470 SACE_2821 SACE_3146 SACE_3150 SACE_3272 SACE_4170 SACE_4379 SACE_4486 SACE_4512 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | SACE_0040 SACE_4036 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | SACE_5753 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_2819 SACE_2477 SACE_4377 SACE_3556 SACE_3548 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4170 SACE_3272 SACE_3150 SACE_2821 SACE_2470 SACE_1686 SACE_3146 SACE_4514 SACE_4512 SACE_4486 SACE_4379 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SACE_4514 SACE_3150 SACE_4379 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SACE_4378 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_2819 SACE_4377 SACE_3556 SACE_3548 SACE_2477 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_2821 SACE_1686 SACE_4514 SACE_4512 SACE_4486 SACE_4379 SACE_4170 SACE_3272 SACE_3150 SACE_2470 SACE_3146 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SACE_5143 |
ARSC1 (NRULE_0017) | Arsenate reductase | |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SACE_5143 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | SACE_5143 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | SACE_1698 |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | SACE_0764 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | SACE_1774 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | SACE_3590 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | SACE_4379 |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | SACE_4378 |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | SACE_4377 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | SACE_4377 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_4377 SACE_3556 SACE_2819 SACE_2477 SACE_3548 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4514 SACE_3146 SACE_3150 SACE_3272 SACE_4170 SACE_4379 SACE_4486 SACE_4512 SACE_1686 SACE_2470 SACE_2821 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SACE_1374 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | SACE_4203 SACE_5371 |
| C | CHOX (NRULE_0178) | Choline oxidase | SACE_5373 |
Betaine biosynthesis (from glycine)(NFUNC_0050) |
| 必須 | A | GSMT (NRULE_0179) | Glycine/sarcosine N-methyltransferase | |
|---|
SDMT (NRULE_0180) | Dimethylglycine N-methyltransferase | |
| B | GSDMT (NRULE_0181) | Glycine/sarcosine/dimethylglycine N-methyltransferase | SACE_3901 |
Bioplastic degradation(NFUNC_0015) |
| 必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | |
|---|
| B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | SACE_3720 |
| C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
| 任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
|---|
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | SACE_4684 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | SACE_0978 |
BIOB (NRULE_0185) | Biotin synthase | SACE_4683 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | SACE_4382 |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | SACE_4383 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SACE_3511 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | SACE_4382 |
CATC (NRULE_0054) | Muconolactone isomerase | SACE_4383 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SACE_3511 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | SACE_4382 |
CATC (NRULE_0054) | Muconolactone isomerase | SACE_4383 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | SACE_4382 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | SACE_4383 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | SACE_1374 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | SACE_6309 SACE_0218 SACE_0253 SACE_0309 SACE_2400 SACE_2791 SACE_3712 SACE_4437 SACE_4781 SACE_5227 SACE_5348 SACE_5399 SACE_6750 SACE_6769 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | SACE_5348 SACE_5399 SACE_6309 SACE_6750 SACE_6769 SACE_2400 SACE_4437 SACE_3712 SACE_0218 SACE_4781 SACE_5227 SACE_2791 SACE_0253 SACE_0309 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_4928 SACE_3298 SACE_2784 |
|---|
1,3-dichloropropene degradation(NFUNC_0012) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
CAAD (NRULE_0076) | 3-chloroacrylic acid dehalogenase | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | SACE_4661 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
CAADA (NRULE_0077) | 3-chloroacrylic acid dehalogenase alpha subunit | |
CAADB (NRULE_0078) | 3-chloroacrylic acid dehalogenase beta subunit | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | SACE_4661 |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | SACE_0484 |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | SACE_0483 |
ECTC (NRULE_0188) | L-ectoine synthase | SACE_0485 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | SACE_0040 SACE_4036 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | SACE_1023 SACE_0398 SACE_4499 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SACE_0399 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SACE_0400 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SACE_1387 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SACE_4036 SACE_0793 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | SACE_0040 SACE_4036 |
DHPS (NRULE_0144) | Dihydropteroate synthase | SACE_4499 SACE_0398 SACE_1023 |
FOLA (NRULE_0147) | Dihydrofolate reductase | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SACE_0399 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SACE_0400 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SACE_1387 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SACE_4036 SACE_0793 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | SACE_4036 SACE_0040 |
DHPS (NRULE_0144) | Dihydropteroate synthase | SACE_4499 SACE_1023 SACE_0398 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | SACE_0399 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | SACE_0400 |
FOLC (NRULE_0160) | Bifunctional protein FolC | SACE_1387 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | SACE_0793 SACE_4036 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
Gentamicin resistance(NFUNC_0053) |
| 必須 | A | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | |
|---|
| 任意 | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | SACE_3604 SACE_3603 |
|---|
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | SACE_2965 SACE_4364 SACE_4734 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | SACE_2847 |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | SACE_0764 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | SACE_1774 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | SACE_0486 |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | SACE_0484 |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | SACE_0483 |
| | ECTC (NRULE_0188) | L-ectoine synthase | SACE_0485 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_2784 SACE_3298 SACE_4928 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_4928 SACE_3298 SACE_2784 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_2784 SACE_4928 SACE_3298 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_3298 SACE_2784 SACE_4928 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Kanamycin resistance(NFUNC_0052) |
| 必須 | A | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
|---|
| B | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | |
| C | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| 任意 | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | SACE_3604 SACE_3603 |
|---|
| | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | SACE_0733 |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | SACE_1994 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | SACE_0712 SACE_1765 SACE_5414 |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | SACE_0072 |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | SACE_4258 SACE_0570 SACE_0573 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | SACE_0571 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | SACE_5764 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | SACE_0571 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | SACE_0572 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SACE_4514 SACE_3150 SACE_4379 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SACE_4378 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | SACE_4514 SACE_4379 SACE_3150 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | SACE_4378 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_2819 SACE_2477 SACE_3548 SACE_3556 SACE_4377 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4514 SACE_4512 SACE_4486 SACE_4379 SACE_4170 SACE_3272 SACE_3150 SACE_3146 SACE_2821 SACE_2470 SACE_1686 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | SACE_0755 SACE_3297 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | SACE_0407 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | SACE_1604 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | SACE_1860 |
PANC (NRULE_0118) | Pantothenate synthetase | SACE_0406 SACE_5541 |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | SACE_1374 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | SACE_2839 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_2819 SACE_3556 SACE_3548 SACE_2477 SACE_4377 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4170 SACE_4486 SACE_4379 SACE_2821 SACE_2470 SACE_1686 SACE_4514 SACE_4512 SACE_3272 SACE_3146 SACE_3150 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | SACE_3298 SACE_2784 SACE_4928 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | SACE_3513 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | SACE_3514 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | SACE_3512 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | SACE_3510 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | SACE_3511 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | SACE_3513 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | SACE_3514 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | SACE_3512 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | SACE_4011 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
| 必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | SACE_4446 |
|---|
| 任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | |
|---|
| | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | SACE_4447 |
| | PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | |
| | PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | SACE_4425 |
| | PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | SACE_2786 SACE_2123 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | SACE_2884 SACE_2123 SACE_2786 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | SACE_2887 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | SACE_2124 |
RIBE (NRULE_0204) | Riboflavin synthase | SACE_2122 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | SACE_5918 |
|---|
Streptogramin resistance(NFUNC_0027) |
| 必須 | A | VAT (NRULE_0113) | Streptogramin A acetyltransferase | |
|---|
| B | VGB (NRULE_0114) | Virginiamycin B lyase | SACE_3383 |
Streptomycin resistance(NFUNC_0054) |
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | SACE_6537 SACE_5997 |
| 任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | SACE_3144 |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | SACE_4377 SACE_2477 SACE_2819 SACE_3548 SACE_3556 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | SACE_4512 SACE_4379 SACE_4514 SACE_4170 SACE_3272 SACE_3150 SACE_3146 SACE_2821 SACE_4486 SACE_2470 SACE_1686 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | SACE_0462 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | SACE_3700 SACE_0461 SACE_2447 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | SACE_2224 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | SACE_2225 SACE_2410 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | SACE_6269 |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | SACE_6268 |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | SACE_6267 |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | SACE_6266 |
| C | BCCT (NRULE_0220) | BCCT family transporter | SACE_0076 SACE_0827 SACE_2490 SACE_4607 SACE_4487 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | SACE_0630 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | SACE_3460 SACE_4548 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| 必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | SACE_2009 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | SACE_2017 |
