Acid resistance (by GABA antiporter)(NFUNC_0071) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | RAM_45505 |
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | RAM_03780 |
Alginate degradation(NFUNC_0062) |
必須 | A | ALGL (NRULE_0226) | Alginate lyase | |
B | ALY (NRULE_0227) | Alginate lyase | RAM_20915 |
n-alkane hydroxylation(NFUNC_0008) |
必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | RAM_32810 |
C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | RAM_22025 RAM_22015 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | RAM_22025 RAM_22015 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_12795 RAM_07965 RAM_10140 RAM_19825 RAM_20960 RAM_22020 RAM_34595 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | RAM_22030 |
任意 | | RUBA (NRULE_0039) | Rubredoxin | RAM_32810 |
| RUBB (NRULE_0040) | Rubredoxin reductase | |
| MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_41075 RAM_12805 RAM_11215 RAM_38855 RAM_20970 RAM_21425 RAM_21860 RAM_19150 RAM_13875 RAM_25905 RAM_29205 RAM_38825 RAM_20810 |
D-allose biosynthesis(NFUNC_0077) |
必須 | A | LRHI (NRULE_0242) | L-rhamnose isomerase | RAM_23140 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | RAM_23750 RAM_05460 |
B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | RAM_26100 RAM_18065 |
任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_10140 RAM_19825 RAM_20960 RAM_22020 RAM_34595 RAM_07965 RAM_12795 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_11215 RAM_12805 RAM_13875 RAM_19150 RAM_20810 RAM_20970 RAM_21425 RAM_21860 RAM_25905 RAM_29205 RAM_38825 RAM_38855 RAM_41075 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_22320 RAM_09290 RAM_02005 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | RAM_00235 |
TRPE (NRULE_0143) | Anthranilate synthase component I | RAM_11665 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_07965 RAM_34595 RAM_22020 RAM_20960 RAM_19825 RAM_12795 RAM_10140 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_20970 RAM_20810 RAM_19150 RAM_13875 RAM_12805 RAM_11215 RAM_41075 RAM_38855 RAM_38825 RAM_29205 RAM_25905 RAM_21860 RAM_21425 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_09290 RAM_02005 RAM_22320 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | RAM_30070 RAM_24775 |
B | AZR (NRULE_0237) | NADPH azoreductase | |
C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | RAM_38825 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | RAM_37080 RAM_36650 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_22020 RAM_19825 RAM_12795 RAM_34595 RAM_10140 RAM_07965 RAM_20960 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_20970 RAM_41075 RAM_21425 RAM_21860 RAM_25905 RAM_29205 RAM_38825 RAM_38855 RAM_13875 RAM_12805 RAM_11215 RAM_19150 RAM_20810 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_09290 RAM_22320 RAM_02005 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC1 (NRULE_0017) | Arsenate reductase | |
B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RAM_03870 |
ARSC1 (NRULE_0017) | Arsenate reductase | |
E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RAM_03870 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RAM_03870 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | RAM_12455 |
| ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | RAM_42780 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | RAM_12280 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | RAM_33320 RAM_06125 RAM_23605 |
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_22020 RAM_34595 RAM_12795 RAM_10140 RAM_07965 RAM_19825 RAM_20960 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_41075 RAM_11215 RAM_12805 RAM_13875 RAM_19150 RAM_20810 RAM_20970 RAM_21425 RAM_21860 RAM_25905 RAM_29205 RAM_38825 RAM_38855 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_09290 RAM_02005 RAM_22320 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | RAM_26100 RAM_18065 |
B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
C | BLAC (NRULE_0124) | Beta-lactamase class C | |
D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | RAM_38845 |
B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | RAM_13295 RAM_38835 |
C | CHOX (NRULE_0178) | Choline oxidase | |
Bioplastic degradation(NFUNC_0015) |
必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | |
B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | RAM_30165 RAM_19035 RAM_20645 RAM_38340 RAM_30505 |
C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | RAM_33175 |
任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
Biotin biosynthesis(NFUNC_0051) |
必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | RAM_11275 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | RAM_11290 |
BIOB (NRULE_0185) | Biotin synthase | RAM_11295 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RAM_09450 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RAM_09450 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | RAM_26100 RAM_18065 |
| BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | RAM_23685 RAM_46980 RAM_44510 RAM_42000 RAM_38505 RAM_35915 RAM_31315 RAM_31305 RAM_25505 RAM_19995 RAM_18735 RAM_17630 RAM_12970 RAM_01380 |
CLCE (NRULE_0384) | Maleylacetate reductase | RAM_30720 |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | RAM_46980 RAM_31315 RAM_35915 RAM_38505 RAM_42000 RAM_44510 RAM_01380 RAM_12970 RAM_17630 RAM_18735 RAM_19995 RAM_23685 RAM_25505 RAM_31305 |
CLCE (NRULE_0384) | Maleylacetate reductase | RAM_30720 |
任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | RAM_36630 |
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_36620 RAM_36915 RAM_35210 RAM_26705 RAM_12835 |
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | RAM_07415 RAM_12830 RAM_29140 RAM_47725 |
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | RAM_21495 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | RAM_21490 |
B | EDIO (NRULE_0058) | extradiol dioxygenase | RAM_29140 RAM_07415 RAM_12830 RAM_47725 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | RAM_21495 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | RAM_21490 |
Ectoine biosynthesis(NFUNC_0056) |
必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | RAM_44120 |
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | RAM_44125 |
ECTC (NRULE_0188) | L-ectoine synthase | RAM_44115 |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | RAM_00235 |
DHPS (NRULE_0144) | Dihydropteroate synthase | RAM_19760 RAM_37020 RAM_44875 RAM_06870 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RAM_44870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RAM_44865 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RAM_34460 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RAM_42400 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | RAM_00235 |
DHPS (NRULE_0144) | Dihydropteroate synthase | RAM_37020 RAM_06870 RAM_19760 RAM_44875 |
FOLA (NRULE_0147) | Dihydrofolate reductase | RAM_20935 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RAM_44870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RAM_44865 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RAM_34460 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RAM_42400 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
C | GLAT (NRULE_0142) | Glutamine amidotransferase | RAM_00235 |
DHPS (NRULE_0144) | Dihydropteroate synthase | RAM_37020 RAM_06870 RAM_19760 RAM_44875 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RAM_44870 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RAM_44865 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RAM_34460 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RAM_42400 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | RAM_45505 |
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | RAM_28665 |
B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
| GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | RAM_42780 |
| GALE (NRULE_0111) | UDP-glucose 4-epimerase | RAM_12280 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | RAM_44110 |
任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | RAM_44120 |
| ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | RAM_44125 |
| ECTC (NRULE_0188) | L-ectoine synthase | RAM_44115 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_36915 RAM_35210 RAM_26705 RAM_12835 RAM_36620 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_36620 RAM_36915 RAM_35210 RAM_26705 RAM_12835 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_36915 RAM_12835 RAM_26705 RAM_35210 RAM_36620 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_12835 RAM_36620 RAM_35210 RAM_26705 RAM_36915 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
D | ERE (NRULE_0168) | Erythromycin esterase | RAM_44465 RAM_08915 |
E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | RAM_03775 RAM_43700 RAM_43685 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | RAM_43695 RAM_22215 RAM_20560 RAM_29490 RAM_41060 |
D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | RAM_11515 RAM_15305 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | RAM_41060 RAM_43695 RAM_29490 RAM_22215 RAM_20560 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | RAM_43690 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Mycosamine biosynthesis(NFUNC_0095) |
必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | RAM_00585 |
任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | RAM_38825 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | RAM_36650 RAM_37080 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | RAM_07415 RAM_12830 RAM_47725 RAM_29140 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | RAM_38825 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | RAM_36650 RAM_37080 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | RAM_47725 RAM_12830 RAM_29140 RAM_07415 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_22020 RAM_20960 RAM_19825 RAM_12795 RAM_10140 RAM_07965 RAM_34595 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_38825 RAM_11215 RAM_12805 RAM_13875 RAM_19150 RAM_20810 RAM_20970 RAM_21425 RAM_21860 RAM_25905 RAM_29205 RAM_38855 RAM_41075 |
| FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_02005 RAM_22320 RAM_09290 |
Nitrile hydratase(NFUNC_0002) |
必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
| COBW (NRULE_0007) | CobW/P47K family protein | RAM_21155 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | RAM_44830 RAM_25625 |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | RAM_06135 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | RAM_23300 RAM_37340 |
PANC (NRULE_0118) | Pantothenate synthetase | RAM_44835 |
Penicillin resistance(NFUNC_0047) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | RAM_18065 RAM_26100 |
B | BLAD (NRULE_0125) | Beta-lactamase class D | |
任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Phenol degradation(NFUNC_0028) |
必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | RAM_22025 RAM_22015 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | RAM_22025 RAM_22015 |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | RAM_30725 |
任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | RAM_02005 RAM_09290 RAM_22320 |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_07965 RAM_22020 RAM_20960 RAM_19825 RAM_12795 RAM_10140 RAM_34595 |
| MME (NRULE_0033) | Multicomponent monooxygenase effector protein | RAM_22030 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_12805 RAM_19150 RAM_29205 RAM_25905 RAM_21860 RAM_13875 RAM_11215 RAM_21425 RAM_20970 RAM_20810 RAM_41075 RAM_38855 RAM_38825 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RAM_35210 RAM_26705 RAM_12835 RAM_36915 RAM_36620 |
Phytic acid hydrolysis(NFUNC_0085) |
必須 | A | PHYT (NRULE_0258) | 3-phytase | RAM_11615 |
B | APPA (NRULE_0259) | Periplasmic AppA protein | |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | RAM_09445 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | RAM_09440 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | RAM_09455 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RAM_09450 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | RAM_09445 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | RAM_09440 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RAM_09435 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | RAM_40415 |
任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | |
| PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | RAM_40430 |
| PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | |
| PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | RAM_40425 |
| PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | RAM_14095 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | RAM_16985 RAM_42865 RAM_26775 RAM_46635 RAM_14095 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | RAM_14100 |
RIBE (NRULE_0204) | Riboflavin synthase | RAM_14090 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | RAM_32420 |
Streptomycin resistance(NFUNC_0054) |
必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
C | APH6 (NRULE_0155) | Streptomycin 6-kinase | RAM_05460 RAM_23750 |
任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | RAM_33675 |
B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | RAM_22015 RAM_22025 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | RAM_22025 RAM_22015 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | RAM_10140 RAM_34595 RAM_22020 RAM_20960 RAM_19825 RAM_12795 RAM_07965 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | RAM_22030 |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RAM_21860 RAM_25905 RAM_29205 RAM_38825 RAM_38855 RAM_41075 RAM_11215 RAM_12805 RAM_13875 RAM_19150 RAM_20810 RAM_20970 RAM_21425 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | RAM_13175 |
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | RAM_13180 |
任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | RAM_13170 RAM_15565 RAM_13185 |
Trehalose biosynthesis (from maltose)(NFUNC_0034) |
必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase | |
TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase | |
B | TRES (NRULE_0128) | Trehalose synthase | RAM_13195 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | RAM_44490 |
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | RAM_44495 |
Vancomycin resistance (via D-Ala-D-Lac precursor)(NFUNC_0089) |
必須 | A | VANA (NRULE_0265) | D-alanine--D-lactate ligase | RAM_42565 |
VANH (NRULE_0266) | D-specific alpha-keto acid dehydrogenase | RAM_42570 |
VANX (NRULE_0267) | D-alanyl-D-alanine dipeptidase | RAM_42560 |
任意 | | VANYA (NRULE_0274) | D-alanyl-D-alanine carboxypeptidase | |
| VANYB (NRULE_0275) | D-alanyl-D-alanine carboxypeptidase | |
| VANYD (NRULE_0276) | D-alanyl-D-alanine carboxypeptidase | |
| VANY (NRULE_0277) | D-alanyl-D-alanine carboxypeptidase | |
| VANYN (NRULE_0278) | D-alanyl-D-alanine dipeptidase/D-alanyl-D-alanine carboxypeptidase | |
| VANRA (NRULE_0279) | Two-component system response regulator VanR | |
| VANRB (NRULE_0280) | Two-component system response regulator VanR | |
| VANRD (NRULE_0282) | Putative two-component system response regulator VanR | |
| VANR (NRULE_0284) | Two-component system response regulator VanR | RAM_42550 |
| VANSA (NRULE_0285) | Two-component system histidine kinase VanS | |
| VANSB (NRULE_0286) | Two-component system histidine kinase VanS | |
| VANSD (NRULE_0288) | Putative two-component system histidine kinase VanS | |
| VANSM (NRULE_0289) | Putative two-component system histidine kinase VanS | |
| VANS (NRULE_0290) | Two-component system histidine kinase VanS | RAM_42555 RAM_41825 |
| VANZ (NRULE_0291) | Teicoplanin resistance protein | |
| VANW (NRULE_0292) | Putative vancomycin resistance protein | |
| VANJ (NRULE_0295) | Teicoplanin resistance protein | |
| VANK (NRULE_0296) | Glycyltransferase VanK | |
| MURF2 (NRULE_0297) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | RAM_43430 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | RAM_11905 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | RAM_27070 |
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | RAM_27025 |